Dan, Katsuaki Katoh, Naohiro Matsuoka, Takaaki Fujinami, Katsuyuki
Published in
Pharmacology
Background: Historical evidence has verified the multifaceted antiviral efficacy of polyoxometalates (PMs). Methods: We carried out a study to investigate the antimicrobial effects of each of the 5 substances comprising virus block (VB): 3 PMs that have antibacterial and antiviral activity, an antibiotic agent, and an antibacterial agent. We also i...
Liu, Jing Deng, Tan Wang, Yaxin Zhang, Mengmeng Zhu, Guannan Fang, Haiming Wang, Jiajia
Published in
Pharmacology
Background: Intestinal fibrosis is the major complication of Crohn’s disease (CD). There are no other good treatments for CD except surgery and remains a refractory disease. Calycosin (CA), the active component of astragalus membranaceus, has been reported the potential effect on lung fibrosis and renal fibrosis. In this study, we aim to explore th...
Mao, Qing Guo, Fenfen Liang, Xiulin Wu, Yufu Lu, Yongxiang
Published in
Pharmacology
Background: Coronary microembolisation (CME)-induced myocardial apoptosis is a key factor in progressive cardiac dysfunction. Aloperine (ALO) plays a protective role in the cardiovascular system, but its role and the mechanism underlying its protection against CME are unclear. Therefore, we aimed to verify whether ALO has a protective effect again...
Zhang, Ying Ren, Shaoyu Ji, Ying Liang, Yafeng
Published in
Pharmacology
Background: Our study investigated the therapeutic role and potential mechanisms of pterostilbene (PS) in diabetic nephropathy (DN) rats. Methods: DN models were established by high-fat diet after streptozotocin injection. A total of 50 Sprague-Dawley rats were randomly divided into control, DN, PS-treated groups (PS-H, PS-M, PS-L). PS was administ...
Naguy, Ahmed Adel, Tarek Almazeedi, Ibrahim
Published in
Pharmacology
Background: Paliperidone is FDA-approved for schizophrenia aged 12–17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential. Methods: EMBASE, Ovid MEDLINE, PubMed, Scopus, Web of Scienc...
Ishikawa, Hideki Mutoh, Michihiro Abe, Takashi Nakajima, Takeshi Takeuchi, Yoji Ezoe, Yasumasa Wakabayashi, Keiji Doyama, Hisashi Sakai, Toshiyuki
Published in
Pharmacology
Mesalazine is the gold standard drug for treatment of ulcerative colitis (UC). Here, we describe 4 cases of familial adenomatous polyposis (FAP) patients with UC that showed reduction of intestinal polyp diameter by mesalazine treatment. Of note, the effects of mesalazine on the development of intestinal polyps in FAP patients have not been reporte...
Liccioli, Giulia Marrani, Edoardo Giani, Teresa Simonini, Gabriele Barni, Simona Mori, Francesca
Published in
Pharmacology
Introduction: Acute generalized exanthematous pustulosis (AGEP) is a generalized, non-follicular sterile pustular rash, categorized as a severe cutaneous adverse reaction, which usually has a favorable prognosis. In a majority of cases (90%), AGEP is drug induced and different drugs are reported as cause of AGEP. Hydroxychloroquine (HCQ) is an anti...
Alqahtani, Saeed Alzaidi, Thuraya Alotaibi, Mashal Alsultan, Abdullah
Published in
Pharmacology
Objective: This study aimed to assess the population pharmacokinetics of phenytoin in Saudi patients and identify factors affecting therapeutic parameters. Method: A retrospective chart review was performed at King Saud University Medical City on patients treated with oral phenytoin. We used Monolix 4.4. for population pharmacokinetic modeling. A b...
Obara, Keisuke Fujii, Ayano Arie, Chiaki Harada, Natsuki Yamaki, Fumiko Matsuo, Kazuhiro Yoshio, Takashi Tanaka, Yoshio
Published in
Pharmacology
Background/Aims: Extrapyramidal symptoms (EPS) are representative side effects of antipsychotics, caused by their inhibitory action on dopaminergic nerves in nigrostriatal pathways. EPS could be also caused by direct augmentation of cholinergic effects, for example, by acetylcholinesterase (AChE) inhibition. We investigated the potential inhibitory...
Zhang, Fei-xue Liu, Xiu-fen Ke, Zhi-qiang Wu, Ning-hua Chen, Hong-guang Liu, Chao
Published in
Pharmacology
Background: Endothelium-dependent dilatation is a predictor for vascular function. NADPH oxidase-derived O2– can inactivate nitric oxide and induce vascular injury. Method: The crude ethanolic extract of Lysimachia christinae Hance were separated out 4 fractions of different olarities by petroleum ether, ethyl acetate, n-butanol (NB), and aqueous. ...
