Sepandi, Mojtaba Abbaszadeh, Sepideh Qobady, Saeid Taghdir, Maryam
Published in
Pharmacological research
Several studies have examined the effect of oral L-Arginine supplementation on lipid profiles and inflammatory markers. However, findings are inconsistent in this regard. Therefore, the aim of this study is to summarize and examine the effect of L-Arginine supplementation on lipid profiles and inflammatory markers in published randomized controlled...
Sutanto, Henry Laudy, Lian Clerx, Michael Dobrev, Dobromir Crijns, Harry J G M Heijman, Jordi
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Pharmacological research
Cardiac arrhythmias are a global health burden, contributing significantly to morbidity and mortality worldwide. Despite technological advances in catheter ablation therapy, antiarrhythmic drugs (AADs) remain a cornerstone for the management of cardiac arrhythmias. Experimental and translational studies have shown that commonly used AADs exert mult...
Paolini, Enrico Stronati, Giulia Guerra, Federico Capucci, Alessandro
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Pharmacological research
Over the last 35 years, flecainide proved itself one of the most commonly used arrhythmic drugs, expanding its original indication for ventricular arrhythmias and results nowadays as the cornerstone of the rhythm control strategy in atrial fibrillation management of patients without structural heart disease. While the increased mortality associated...
Khan, Imran Huang, Guoxin Li, Xiao-Ang Liao, Weilin Leong, Wai Kit Xia, Wenrui Bian, Xiqing Wu, Jianlin Hsiao, W L Wendy
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Pharmacological research
The incidence of colorectal cancer (CRC) is alarming among younger peoples. While no effective chemopreventive drug available in the market, researchers have been searching for alternative strategies against CRC that are in demand. Therefore, we tested the cancer-preventive properties of Ganoderma lucidum (Lingzhi) polysaccharides (GLP), along with...
Morris, Gerwyn Puri, Basant K Walker, Adam J Maes, Michael Carvalho, Andre F Walder, Ken Mazza, Catherine Berk, Michael
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Pharmacological research
Myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS) is a common and disabling condition with a paucity of effective and evidence-based therapies, reflecting a major unmet need. Cognitive behavioural therapy and graded exercise are of modest benefit for only some ME/CFS patients, and many sufferers report aggravation of symptoms of fati...
Yang, Niao Yue, Rongcai Ma, Jinzhu Li, Wencai Zhao, Zeng Li, Huiliang Shen, Yunheng Hu, Zhenlin Lv, Chao Xu, Xike
...
Published in
Pharmacological research
In the effort to identify natural products that regulate immunity and inflammation, we found that nitidine chloride (NC), an alkaloid from herb Zanthoxylum nitidum, enhanced IL-10 production in lipopolysaccharide (LPS)-stimulated myeloid cells. While NC was shown to be capable of inhibiting topoisomerase I (TOP1), NC analogs that could not inhibit ...
Cavalcante, Paola Mizrachi, Tehila Barzago, Claudia Scandiffio, Letizia Bortone, Federica Bonanno, Silvia Frangiamore, Rita Mantegazza, Renato Bernasconi, Pia Brenner, Talma
...
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Pharmacological research
Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular transmission currently treated with chronic immunosuppression. Inter-subject variation in treatment response and side effects highlight the need for personalized therapies by identification of biomarkers predictive of drug efficacy in individual patients, still lacking in MG. ...
Lu, Hong-Yuan Zu, Yu-Xin Jiang, Xiao-Wen Sun, Xiao-Tong Liu, Tian-Yi Li, Ruo-Lan Wu, Qiong Zhang, Ying-Shi Zhao, Qing-Chun
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Pharmacological research
Acquired drug-resistant non-small cell lung cancer (NSCLC) has strong proliferation ability and is prone to epithelial-mesenchymal transition (EMT) and subsequent metastasis. Notch pathway mediates cell survival and EMT and is involved in the induction of multidrug resistance (MDR). ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17...
Liang, Jian Li, Hailun Chen, Jianqiang He, Lian Du, Xianhua Zhou, Lian Xiong, Qingping Lai, Xiaoping Yang, Yiqi Huang, Song
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Pharmacological research
Intact epithelial barrier and mucosal immune system are crucial for maintaining intestinal homeostasis. Previous study indicated that Dendrobium officinale polysaccharides (DOPS) can regulate immune responses and inflammation to alleviate experimental colitis. However, it remains largely unknown whether DOPS can suppress AOM/DSS-induced colorectal ...
Nadeem, Ahmed Ahmad, Sheikh F Al-Harbi, Naif O Ibrahim, Khalid E Siddiqui, Nahid Al-Harbi, Mohammed M Attia, Sabry M Bakheet, Saleh A
Published in
Pharmacological research
Asthma is a complex airways disease with a wide spectrum which ranges from eosinophilic (Th2 driven) to mixed granulocytic (Th2/Th17 driven) phenotypes. Mixed granulocytic asthma is a cause of concern as corticosteroids often fail to control this phenotype. Different kinases such as Brutons's tyrosine kinase (BTK) and IL-2 inducible T cell kinase (...
