Methodological education in response to the quality of COVID-19 publications.
Published in Pharmacological research
Effect of proanthocyanidins on blood pressure: A systematic review and meta-analysis of randomized controlled trials.
Published in Pharmacological research
Hypertension is a common chronic disease that can lead to serious health problems. Previous studies have not drawn a consistent conclusion about the effect of proanthocyanidins (PCs) on blood pressure (BP). This systematic review and meta-analysis aims to evaluate the effect of PCs supplementation on blood pressure (BP). A comprehensive literature ...
Interaction of nobiletin with methotrexate ameliorates 7-OH methotrexate-induced nephrotoxicity through endoplasmic reti...
...Published in Pharmacological research
Drug-induced nephrotoxicity is a frequent adverse event that contributes to acute kidney injury with tubular and/or glomerular lesions. Methotrexate (MTX) is a folate analog used against a myriad of malignancies and autoimmune diseases. Unfortunately, ambiguous renal toxicology limits its safe clinical usage. Based on our previous studies, 7-OH MTX...
20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes.
...Published in Pharmacological research
Osteoarthritis (OA) is an age-related degenerative disease and currently cannot be cured. Transcription factor EB (TFEB) is one of the major transcriptional factors that regulates autophagy and lysosomal biogenesis. TFEB has been shown to be an effective therapeutic target for many diseases including OA. The current study explores the therapeutic e...
Role of mitophagy in mitochondrial quality control: Mechanisms and potential implications for neurodegenerative diseases...
Published in Pharmacological research
Neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis) commonly characterized by the gradual loss of neurons have a seriously bad impact on motor and cognitive abilities of affected humans and bring great inconvenience to their lives. Mitochondrial dysfunction has been co...
Phytochemicals as regulators of microglia/macrophages activation in cerebral ischemia.
Published in Pharmacological research
The search for novel therapeutic agents for the management of cerebral ischemia/stroke has become an appealing research interest in the recent past. Neuroprotective phytochemicals as novel stroke drug candidates have recently drawn significant interests from stroke scientists due to their strong brain protective effects in animal stroke models. The...
The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinog...
Published in Pharmacological research
Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the regulation of inflammation, carc...
Anlotinib enhances the antitumor activity of radiofrequency ablation on lung squamous cell carcinoma.
Published in Pharmacological research
Anlotinib is a novel molecular targeted drug that has been approved for the treatment of lung adenocarcinoma. Currently these agents are rarely used in the treatment of lung squamous cell carcinoma (LSCC). Bronchoscope-guided radiofrequency ablation (RFA) is a new strategy proposed for the treatment of LSCC that is able to alleviate the obstruction...
Dendritic cell vaccine therapy for colorectal cancer.
Published in Pharmacological research
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths in the United States despite an array of available treatment options. Current standard-of-care interventions for this malignancy include surgical resection, chemotherapy, and targeted therapies depending on the disease stage. Specifically, infusion of anti-vascular endothelial...
Consumption of antibiotics at an Italian university hospital during the early months of the COVID-19 pandemic: Were all ...
...Published in Pharmacological research
