Memariani, Zahra Abbas, Syed Qamar Ul Hassan, Syed Shams Ahmadi, Amirhossein Chabra, Aroona
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Pharmacological research
Although the rates of many cancers are controlled in Western countries, those of some cancers, such as lung, breast, and colorectal cancer are currently increasing in many low- and middle-income countries due to increases in risk factors caused by development and societal problems. Additionally, endogenous factors, such as inherited mutations, ster...
Wang, Dongsheng Wu, Zhixiang Zhao, Chenglong Yang, Xinghai Wei, Haifeng Liu, Mingyao Zhao, Jian Qian, Ming Li, Zhenxi Xiao, Jianru
...
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Pharmacological research
Rheumatoid arthritis (RA) is an autoimmune disease mainly characterized as chronic inflammation of joint. Both genetic and environmental factors play important roles in RA progression. G protein-coupled receptor 54 (GPR54) and Kisspeptins (KPs), the natural GRP54 ligands encoded by Kiss-1 gene are known to play important roles in immune regulation ...
Bazrgar, Maryam Khodabakhsh, Pariya Prudencio, Mercedes Mohagheghi, Fatemeh Ahmadiani, Abolhassan
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Pharmacological research
Growing evidence indicates that overexpression of the microRNA-34 (miR-34) family in the brain may play a crucial role in Alzheimer's disease (AD) pathogenesis by targeting and downregulating genes associated with neuronal survival, synapse formation and plasticity, Aβ clearance, mitochondrial function, antioxidant defense system, and energy metabo...
He, Yu Luo, Yang Huang, Lan Zhang, Dan Wang, Xixi Ji, Jiayi Liang, Shufang
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Pharmacological research
Renal cell carcinoma (RCC) is a highly vascularized tumor and prone to distant metastasis. Sorafenib is the first targeted multikinase inhibitor and first-line chemical drug approved for RCC therapy. In fact, only a small number of RCC patients benefit significantly from sorafenib treatment, while the growing prevalence of sorafenib resistance has ...
Kessler, Julie Totoson, Perle Devaux, Sylvie Moretto, Johnny Wendling, Daniel Demougeot, Céline
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Pharmacological research
Although cardiac diseases such as acute myocardial infarction, heart failure and arrhythmias are the leading cause of cardiovascular complications in rheumatoid arthritis (RA), their pathogenesis is far from being understood and optimal therapeutic options to treat specifically these disorders in RA are lacking. Preclinical studies on animal models...
Huang, Jia-Ting Mao, Yu-Qin Han, Bing Zhang, Zheng-Yan Chen, Hui-Ling Li, Zhan-Ming Kong, Chao-Yue Xu, Jia-Qi Cai, Pei-Ran Zeng, Yu-Peng
...
Published in
Pharmacological research
Calorie restriction can modulate the gut microbiota and protect against many diseases including ischemic stroke. However, the role of calorie-restriction-induced microbiota alteration remained unknown in ischemic stroke rehabilitation. Here we conducted 30% reduction of caloric intake on mice for four weeks, to evaluate its role on ischemic stroke ...
Dashti, Fatemeh Mousavi, Seyed Mohammad Larijani, Bagher Esmaillzadeh, Ahmad
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Pharmacological research
on the level of inflammatory cytokines following vitamin D supplementation among individuals with abnormal glucose homeostasis (AGH) are controversial. Therefore, the present study was conducted on AGH patients to assess the impact of vitamin D on inflammatory cytokines such as CRP, TNF-α and IL-6. A systematic search up to September 2020 was perfo...
Miao, Chenggui Wang, Xiao Zhou, Wanwan Huang, Jinling
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Pharmacological research
Autoimmune diseases include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic vasculitis, dermatomyositis, systemic sclerosis (SSc), mixed connective tissue disease, autoimmune hemolytic anemia, autoimmune thyroiditis (AITD) and ulcerative colitis. Exosomes exist in body fluids, including blood, saliva, urine, cerebrospinal fl...
Aviram, Joshua Lewitus, Gil M Pud, Dorit Procaccia, Shiri Berman, Paula Yellin, Ben Vysotski, Yelena Hazan, Or Eisenberg, Elon Meiri, David
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Published in
Pharmacological research
Medical cannabis (MC) treatment for chronic pain is increasing, but evidence regarding short- and long-term efficacy and associated adverse effects (AEs) of the different cannabis plant components is limited. Most reports focus on two phytocannabinoids, (-)-Δ9-trans-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). This study, aimed to identify ...
Testa, Giovanna Cattaneo, Antonino Capsoni, Simona
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Pharmacological research
Nerve growth factor (NGF), by binding to TrkA and p75NTR receptors, regulates the survival and differentiation of sensory neurons during development and mediates pain transmission and perception during adulthood, by acting at different levels of the nervous system. Key to understanding the role of NGF as a pain mediator is the finding that mutation...
