Aguilar-Recarte, David Barroso, Emma Zhang, Meijian Rada, Patricia Pizarro-Delgado, Javier Peña, Lucía Palomer, Xavier Valverde, Ángela M Wahli, Walter Vázquez-Carrera, Manuel
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Pharmacological research
Metformin, the most prescribed drug for the treatment of type 2 diabetes mellitus, has been recently reported to promote weight loss by upregulating the anorectic cytokine growth differentiation factor 15 (GDF15). Since the antidiabetic effects of metformin are mostly mediated by the activation of AMPK, a key metabolic sensor in energy homeostasis,...
Noormohammadi, Morvarid Ghorbani, Zeinab Löber, Ulrike Mahdavi-Roshan, Marjan Bartolomaeus, Theda U P Kazemi, Asma Shoaibinobarian, Nargeskhatoon Forslund, Sofia K
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Pharmacological research
Recent studies have demonstrated the effect of probiotics, prebiotics, and synbiotics on adiponectin and leptin levels; however, those findings remain contested. The present study aimed to explore the impact of probiotics/synbiotics on appetite-regulating hormones and the desire to eat. A systematic review was conducted by searching the Medline (Pu...
Wang, Rongbo Lee, Yeong-Geun Dhandapani, Sanjeevram Baek, Nam-In Kim, Kwang-Pyo Cho, Yeong-Eun Xu, Xingyue Kim, Yeon-Ju
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Pharmacological research
Gastric cancer (GC) occurs in the gastric mucosa, and its high morbidity and mortality make it an international health crisis. Therefore, novel drugs are needed for its treatment. The use of natural products and their components in cancer treatments has shown promise. Therefore, this study aimed to evaluate the effect of 8-paradol, a phenolic compo...
Tong, Fei Zhao, Ji-Xing Fang, Zi-Yuan Cui, Xiao-Teng Su, Dong-Yuan Liu, Xing Zhou, Jun-Hu Wang, Guang-Xiu Qiu, Zhi-Jun Liu, Shi-Zhong
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Pharmacological research
Epidermal growth factor receptor variant III (EGFRvIII) is a mutant isoform of EGFR with a deletion of exons 2-7 making it insensitive to EGF stimulation and downstream signal constitutive activation. However, the mechanism underlying the stability of EGFRvIII remains unclear. Based on CRISPR-Cas9 library screening, we found that mucin1 (MUC1) is e...
Hu, Rui Li, Yao Guo, Ying Li, Xin Du, Songtao Liao, Mengting Hou, Huihui Sun, Hongyin Zhao, Shuang Su, Juan
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Pharmacological research
BET inhibition or BRD4 depletion is a promising and attractive therapy for metastatic melanoma; however, the mechanism is still unclear. Here, we indicated that BET inhibition suppressed melanoma metastasis both in vitro and in vivo and identified a new mechanism by which BET inhibitors suppress melanoma metastasis by blocking the direct interactio...
Malheiro, Rui Filipe Carmo, Helena Carvalho, Félix Silva, João Pedro
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Pharmacological research
Mitochondria play a critical role in the regulation of several biological processes (e.g., programmed cell death, inflammation, neurotransmission, cell differentiation). In recent years, accumulating findings have evidenced that cannabinoids, a group of endogenous and exogenous (synthetic and plant-derived) psychoactive compounds that bind to canna...
Lu, Yao Zhang, Jian Han, Bing Yu, Yue Zhao, Wei Wu, Tianyu Mao, Yangming Zhang, Fengxiang
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Pharmacological research
As a pathological myocardial remodeling process in a variety of cardiovascular diseases, cardiac hypertrophy still has no effective treatment. Human mesenchymal stem cells (hMSCs) derived extracellular vesicles (EVs) has been recognized as a promising treatment strategy for cardiac disease. In this study, the inhibitory effects on cardiac hypertrop...
Sciorati, Clara De Lorenzo, Rebecca Lorè, Nicola I Tresoldi, Cristina Cirillo, Daniela M Ciceri, Fabio Corti, Angelo Manfredi, Angelo A Rovere-Querini, Patrizia
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Pharmacological research
Wu, Tiangang Wang, Mengling Ning, Fengling Zhou, Shilin Hu, Xuetao Xin, Hong Reilly, Svetlana Zhang, Xuemei
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Pharmacological research
Fibrosis is a common pathological feature of organ diseases resulting from excessive production of extracellular matrix, which accounts for significant morbidity and mortality. However, there is currently no effective treatment targeting fibrogenesis. Recently, metabolic alterations are increasingly considered as essential factors underlying fibrog...
Fiore, Giulia Pascuzzi, Martina Chiara Di Profio, Elisabetta Corsello, Antonio Agostinelli, Marta La Mendola, Alice Milanta, Chiara Campoy, Cristina Calcaterra, Valeria Zuccotti, Gianvincenzo
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Pharmacological research
Obesity represents the most frequent chronic disease among children worldwide, with a significant global burden on society. Metabolically unhealthy obesity (MUO) can affect children since their first years of life, and novel therapeutic strategies to tackle metabolic complications are under investigation. This review focuses on bioactive compounds ...
