Białoń, Magdalena Chocyk, Agnieszka Majcher-Maślanka, Iwona Żarnowska, Marcelina Michalski, Krzysztof Antkiewicz-Michaluk, Lucyna Wąsik, Agnieszka
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Pharmacological reports : PR
The aim of the present study was to evaluate the effect of 1MeTIQ on fear memory and social interaction in an MK-801-induced model of schizophrenia. The results obtained after administration of 1MeTIQ were compared with those obtained with olanzapine, an antipsychotic drug. Sprague-Dawley rats received a single injection of MK-801 to induce behavio...
Bou-Gharios, Jolie Assi, Sahar Bahmad, Hisham F Kharroubi, Hussein Araji, Tarek Chalhoub, Reda M Ballout, Farah Harati, Hayat Fares, Youssef Abou-Kheir, Wassim
...
Published in
Pharmacological reports : PR
The original article can be found online.
Mei, Xi Zhu, Lina Zhou, Qi Li, Xingxing Chen, Zhongming
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Pharmacological reports : PR
An increasing number of studies have shown that Alzheimer's disease (AD) is a systemic disease characterized by brain dysfunction. In this study, we aimed to investigate the effects of curcumin on the liver, an important metabolic organ, and on the brain in APPswe/PS1dE9 (APP/PS1) mice, and the interaction between these effects. Curcumin was admini...
Martínez-Martínez, Arisaí Muñoz-Islas, Enriqueta Ramírez-Rosas, Martha B Acosta-González, Rosa I Torres-Rodríguez, Héctor F Jiménez-Andrade, Juan M
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Pharmacological reports : PR
Mice lacking either colony-stimulating factor-1 (CSF-1) or its receptor, CSF-1R, display osteopetrosis. Accordingly, genetic deletion or pharmacological blockade of CSF-1 prevents the bone loss associated with estrogen deficiency. However, the role of CSF-1R in osteoporosis models of type-1 diabetes (T1D) and ovariectomy (OVX) has not been examined...
Danek, Przemysław J Wójcikowski, Jacek Daniel, Władysława A
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Pharmacological reports : PR
The present study aimed at examining the inhibitory effect of two atypical neuroleptics iloperidone and lurasidone on the main human cytochrome P450 (CYP) enzymes in pooled human liver microsomes and cDNA-expressed CYP enzymes (supersomes). The activity of these enzymes was determined by the following CYP-specific reactions: caffeine 3-N-demethylat...
Poleszak, Ewa Wośko, Sylwia Sławińska, Karolina Wyska, Elżbieta Szopa, Aleksandra Świąder, Katarzyna Wróbel, Andrzej Szponar, Jarosław Doboszewska, Urszula Wlaź, Piotr
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Pharmacological reports : PR
Though there are several classes of antidepressant drugs available on the pharmaceutical market, depression that affects globally over 320 million people is still undertreated. Scientists have made attempts to develop novel therapeutical strategies to maximize effectiveness of therapy and minimize undesired reactions. One of the ideas is use of eit...
Boretti, Alberto
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Pharmacological reports : PR
The pandemic of SARS CoV-2 has required urgent medical treatments for numerous patients. As no specific antiviral agents were available, different off-the-shelf alternatives have been explored. Here, we review the rationale behind the use of Favipiravir, and report of the specific studies supporting this treatment being conducted. Here we analyze t...
Vilas-Boas, Eloisa Aparecida Karabacz, Noémie Marsiglio-Librais, Gabriela Nunes Valle, Maíra Melo Rezende Nalbach, Lisa Ampofo, Emmanuel Morgan, Bruce Carpinelli, Angelo Rafael Roma, Leticia Prates
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Pharmacological reports : PR
Free fatty acids (FFAs) are known for their dual effects on insulin secretion and pancreatic β-cell survival. Short-term exposure to FFAs, such as palmitate, increases insulin secretion. On the contrary, long-term exposure to saturated FFAs results in decreased insulin secretion, as well as triggering oxidative stress and endoplasmic reticulum (ER)...
Bou-Gharios, Jolie Assi, Sahar Bahmad, Hisham F. Kharroubi, Hussein Araji, Tarek Chalhoub, Reda M. Ballout, Farah Harati, Hayat Fares, Youssef Abou-Kheir, Wassim
...
Published in
Pharmacological Reports
BackgroundGlioblastoma multiforme (GBM), a stage IV astrocytoma, is the most common brain malignancy among adults. Conventional treatments of surgical resection followed by radio and/or chemotherapy fail to completely eradicate the tumor. Resistance to the currently available therapies is mainly attributed to a subpopulation of cancer stem cells (C...
Rana, Tarapati Behl, Tapan Mehta, Vineet Uddin, Md Sahab Bungau, Simona
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Pharmacological reports : PR
Depression is a common psychiatric disorder, the exact pathogenesis of which is still elusive. Studies have proposed that immunity disproportion and enhancement in proinflammatory cytokines might be linked with the development of depression. HMGB1 (High-mobility group box (1) protein has obtained more interest as an essential factor in inherent imm...
