Ragia, Georgia Manolopoulos, Vangelis G
Published in
Pharmacogenomics
There is considerable variation in disease course among individuals infected with SARS-CoV-2. Many of them do not exhibit any symptoms, while some others proceed to develop COVID-19; however, severity of COVID-19 symptoms greatly differs among individuals. Focusing on the early events related to SARS-CoV-2 entry to cells through the ACE2 pathway, w...
Adegbola, Adebanjo J Soyinka, Julius O Bolaji, Oluseye O
Published in
Pharmacogenomics
Aim: We aimed to assess the effect of a functional polymorphism of CYP3A5 on lumefantrine pharmacokinetics. Patients & methods: Sixty-nine women diagnosed with malaria received standard doses of artemether-lumefantrine. Concentration-time data for lumefantrine and genotyping data were obtained for each participant. Pharmacokinetic-genotype associat...
Roosan, Don Hwang, Angela Law, Anandi V Chok, Jay Roosan, Moom R
Published in
Pharmacogenomics
Background: Despite potential benefits, the practice of incorporating pharmacogenomics (PGx) results in clinical decisions has yet to diffuse widely. In this study, we conducted a review of recent discussions on data standards and interoperability with a focus on sharing PGx test results among health systems. Materials & methods: We conducted a lit...
Stäuble, Céline K Lampert, Markus L Mikoteit, Thorsten Hatzinger, Martin Hersberger, Kurt E Meyer Zu Schwabedissen, Henriette E
Published in
Pharmacogenomics
We report the case of a patient with major depression treated with high-dose bupropion due to prior detected subtherapeutic blood concentrations at standard dosing. Pharmacogenetic panel testing identified the patient as a carrier of the CYP2B6*6 allele, which has been associated with reduced bupropion metabolism and decreased concentrations of the...
Joung, Kyung-In Kim, Kwang Hyun Hsieh, Cheng-Yang Shin, Ju-Young
Published in
Pharmacogenomics
Background: Poor clopidogrel metabolizers, carrying a cytochrome P450 2C19 loss-of-function allele, are more frequent among East Asians than Caucasians/White. Materials & methods: The Korea adverse event reporting system database and a case/noncase study design were used to examine the disproportionality of cardiovascular events following clopidogr...
Nagy, Mohamed Eirini Tsermpini, Evangelia Siamoglou, Stavroula Patrinos, George P
Published in
Pharmacogenomics
The pharmacists' role is potentially vital in the growing field of personalized medicine, and well-defined guidelines and knowledge that support this role need to be established. To address the knowledge gap, over the past two decades, pharmacy schools have started providing pharmacogenomics-related courses, a field that overlaps with pharmacy and ...
Gilani, Syed Sa Nair, Nisha Plant, Darren Hyrich, Kimme Morgan, Ann W Morris, Andrew P Wilson, Anthony G Isaacs, John D Barton, Anne Bluett, James
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Published in
Pharmacogenomics
Aim: TNF inhibitor drugs are a treatment option for rheumatoid arthritis, but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 score to determine whether SNPs associated with res...
Serretti, Alessandro Fabbri, Chiara
Published in
Pharmacogenomics
Over 20 years after the initial report of gene variants within the central nervous system modulating antidepressant response, we are now facing for the first time routine clinical pharmacogenetic applications. The scientific community is divided between enthusiasm and skepticism. It seems clear that the benefit of existing tools is not huge, at lea...
Zhu, Jing Pasternak, Amy L Crona, Daniel J
Published in
Pharmacogenomics
Gagno, Sara Bartoletti, Michele Romualdi, Chiara Poletto, Elena Scalone, Simona Sorio, Roberto Zanchetta, Martina De Mattia, Elena Roncato, Rossana Cecchin, Erika
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Published in
Pharmacogenomics
Aim: To define the impact of polymorphisms in genes involved in platinum-taxane and estrogen activity in the outcome of platinum-based treated ovarian cancer patients (OCP). Patients & Methods: Two hundred and thirty OCP were analyzed for 124 germ-line polymorphisms to generate a prognostic score for overall survival (OS), progression-free survival...
