Verster, Joris C Scholey, Andrew Dahl, Thomas A Iversen, Jacqueline M
Published in
Pharmaceutics
SJP-005 (a combination of ketotifen and ibuprofen) is being developed as a potential treatment for pain and for opioid use disorder. It is therefore important to investigate the potential antinociceptive properties of SJP-005. Two studies were conducted to evaluate the potential effects of SJP-005 in rats. Study 1 applied the von Frey test to exami...
Usach, Iris Alaimo, Alessandro Fernández, Juan Ambrosini, Alessandro Mocini, Sara Ochiuz, Lacramioara Peris, José-Esteban
Published in
Pharmaceutics
Magnolia spp. extracts are known for their use in traditional Korean, Chinese, and Japanese medicine in the treatment of gastrointestinal disorders, anxiety, and allergies. Among their main components with pharmacological activity, the most relevant are magnolol and honokiol, which also show antitumoral activity. The objectives of this work were to...
Alshetaili, Abdullah Almutairy, Bjad K. Alshehri, Sultan M. Repka, Michael A.
Published in
Pharmaceutics
The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swellability, low-permeability (Eudragit® RS PO (E-RS))...
Party, Petra Bartos, Csilla Farkas, Árpád Szabó-Révész, Piroska Ambrus, Rita
Published in
Pharmaceutics
Pulmonary delivery has high bioavailability, a large surface area for absorption, and limited drug degradation. Particle engineering is important to develop inhalable formulations to improve the therapeutic effect. In our work, the poorly water-soluble meloxicam (MX) was used as an active ingredient, which could be useful for the treatment of non-s...
Agarwal, Priyanka Craig, Jennifer P Rupenthal, Ilva D
Published in
Pharmaceutics
Dry eye disease (DED) is one of the most common ocular surface disorders characterised by a deficiency in quality and/or quantity of the tear fluid. Due to its multifactorial nature involving several inter-related underlying pathologies, it can rapidly accelerate to become a chronic refractory condition. Therefore, several therapeutic interventions...
Choi, In-Jeong Cha, Hye-Ran Hwang, Su Jin Baek, Seung-Ki Lee, Jae Myun Choi, Seong-O
Published in
Pharmaceutics
Although smallpox has been eradicated globally, the potential use of the smallpox virus in bioterrorism indicates the importance of stockpiling smallpox vaccines. Considering the advantages of microneedle-based vaccination over conventional needle injections, in this study, we examined the feasibility of microneedle-based smallpox vaccination as an...
Vasey, Catherine E Cavanagh, Robert J Taresco, Vincenzo Moloney, Cara Smith, Stuart Rahman, Ruman Alexander, Cameron
Published in
Pharmaceutics
Glioblastoma (GBM) is the most common, malignant and aggressive brain tumour in adults. Despite the use of multimodal treatments, involving surgery, followed by concomitant radiotherapy and chemotherapy, the median survival for patients remains less than 15 months from diagnosis. Low penetration of drugs across the blood-brain barrier (BBB) is a do...
Michaud, Veronique Turgeon, Jacques
Published in
Pharmaceutics
Fadilah, Nur Izzah Md Rahman, Mohd Basyaruddin Abdul Yusof, Loqman Mohamad Mustapha, Noordin Mohamed Ahmad, Haslina
Published in
Pharmaceutics
The standard treatment of open wounds via the direct usage of therapeutic agents is not without limitations with respect to healing. Small peptides can create a favorable milieu for accelerating the healing of wounds. This study presents the potential of a novel fatty acid conjugated tetrapeptide (palmitic acid-glycine-aspartic acid-proline-histidi...
Kim, Min-Ki Ki, Do-Hyung Na, Young-Guk Lee, Hae-Soo Baek, Jong-Suep Lee, Jae-Young Lee, Hong-Ki Cho, Cheong-Weon
Published in
Pharmaceutics
The synthesis process or composition of mesoporous silica nanoparticles (MSNs) affects the physicochemical properties. Using these properties, MSNs were synthesized through the Box–Behnken design (BBD) among statistical experimental methods. The effect of the amounts of synthetic reagents, hexadecyl triethyl ammonium bromide (CTAB), tetraethyl orth...