Naito, Chihiro Katsumi, Hidemasa Yoneto, Kunio Omura, Mao Nishidono, Mayuko Kamei, Sachi Mizoguchi, Akiya Tamba, Ayaka Tanaka, Akiko Morishita, Masaki
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Published in
Pharmaceutics
For efficient transdermal delivery of alendronate (ALN) for anti-osteoporotic therapy, we developed a hyaluronic acid (HA) gel sheet that was prepared simply by enhancing HA noncovalent interactions using phosphoric acid and polyhydric alcohol (propanediol and glycerin). HA solution viscosity increased after addition of phosphoric acid, and the HA ...
Petroková, Hana Mašek, Josef Kuchař, Milan Vítečková Wünschová, Andrea Štikarová, Jana Bartheldyová, Eliška Kulich, Pavel Hubatka, František Kotouček, Jan Knotigová, Pavlína Turánek
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Published in
Pharmaceutics
Development of tools for direct thrombus imaging represents a key step for diagnosis and treatment of stroke. Nanoliposomal carriers of contrast agents and thrombolytics can be functionalized to target blood thrombi by small protein binders with selectivity for fibrin domains uniquely formed on insoluble fibrin. We employed a highly complex combina...
Wasan, Kishor M Badea, Ildiko
Published in
Pharmaceutics
Canada has a long and rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic ...
Hong, Soon-Seok Oh, Kyung Taek Choi, Han-Gon Lim, Soo-Jeong
Published in
Pharmaceutics
Restricted drug entry to the brain that is closely associated with the existence of the blood brain barrier (BBB) has limited the accessibility of most potential active therapeutic compounds to the brain from the systemic circulation. Recently, evidences for the presence of direct nose-to-brain drug transport pathways have been accumulated by sever...
Reyes-Ortega, Felisa Checa Fernández, Blanca Luna Delgado, Angel V Iglesias, Guillermo R
Published in
Pharmaceutics
In this paper, it is proposed that polymer-coated magnetic nanorods (MNRs) can be used with the advantage of a double objective: first, to serve as magnetic hyperthermia agents, and second, to be used as magnetic vehicles for the antitumor drug doxorubicin (DOX). Two different synthetic methodologies (hydrothermal and co-precipitation) were used to...
Gerrard, Stephen E Walsh, Jennifer Bowers, Niya Salunke, Smita Hershenson, Susan
Published in
Pharmaceutics
Despite advances in regulations and initiatives to increase pediatric medicine development, there is still an unmet need for age-appropriate medicines for children. The availability of pediatric formulations is particularly lacking in resource poor areas, due to, for example, area-specific disease burden and financial constraints, as well as discon...
Choi, Young A Song, Im-Sook Choi, Min-Koo
Published in
Pharmaceutics
A sensitive and simple chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to evaluate memantine in rat plasma. Memantine and propranolol (internal standard) in rat plasma was extracted using a methanol precipitation method. The standard curve value was 0.2⁻1000 ng/mL and selectivity, linearity, inter-day and intra-day accuracy ...
Marangoci, Narcisa Timpu, Daniel Corciova, Andreia Mircea, Cornelia Petrovici, Anca-Roxana Nicolescu, Alina Ursu, Elena-Laura Nastasa, Valentin Bostanaru, Andra-Cristina Mares, Mihai
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Published in
Pharmaceutics
In this study, we proposed formulations of diminazene aceturate (DA) designed to improve its bioavailability and to maximize the therapeutic index in animals by overcoming the rapid degradation under the acidic pH of the stomach. An important consequence is the fact that its amount in the bloodstream is close to the administered dose. This was made...
Glowka, Eliza Stasiak, Joanna Lulek, Janina
Published in
Pharmaceutics
Vitamin D (VD) is a fat-soluble prohormone well known for its role in regulating calcium and phosphate metabolism. It has been clinically used for many years to prevent rickets in children, osteomalacia, and osteoporosis in adults. VD insufficiency is a common medical condition, and many supplements are available in the market in order to increase ...
Prokai-Tatrai, Katalin De La Cruz, Daniel L Nguyen, Vien Ross, Benjamin P Toth, Istvan Prokai, Laszlo
Published in
Pharmaceutics
Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide. A representative prodrug based on this design principle was synthesized, and its ...
