Sharipov, Avez Boboev, Zufar Fazliev, Sunnatullo Gulyamov, Shokhid Yunuskhodjayev, Akhmatkhodja Razzokov, Jamoliddin
Published in
Pharmaceutics
Iodine, being an intrinsic part of thyroid hormones, is a vital microelement required for normal growth and development, particularly in children. Inadequate daily intake of iodine causes iodine deficiency, which is responsible for several health disorders, such as cretinism and goiters. Therefore, the development of new drugs and/or food supplemen...
Toja-Camba, Francisco José Gesto-Antelo, Nerea Maroñas, Olalla Echarri Arrieta, Eduardo Zarra-Ferro, Irene González-Barcia, Miguel Bandín-Vilar, Enrique Mangas Sanjuan, Victor Facal, Fernando Arrojo Romero, Manuel
...
Published in
Pharmaceutics
Over the last two decades, pharmacogenetics and pharmacokinetics have been increasingly used in clinical practice in Psychiatry due to the high variability regarding response and side effects of antipsychotic drugs. Specifically, long-acting injectable (LAI) antipsychotics have different pharmacokinetic profile than oral formulations due to their s...
Pünnel, Larissa Carine Lunter, Dominique Jasmin
Published in
Pharmaceutics
Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the formulation forms a solid film. Various film-forming formulations were tested for their water and abrasion resis...
Kim, Sin-Eun Seo, Hyung-Ju Jeong, Yeojin Lee, Gyung-Min Ji, Seung-Bae Park, So-Young Wu, Zhexue Lee, Sangkyu Kim, Sunghwan Liu, Kwang-Hyeon
...
Published in
Pharmaceutics
Donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly prescribed drug for the treatment of Alzheimer's disease. In general, donepezil is known as a safe and well-tolerated drug, and it was not associated with liver abnormalities in several clinical trials. However, rare cases of drug-related liver toxicity hav...
Grigoletto, Antonella Martinez, Gabriele Gabbia, Daniela Tedeschini, Tommaso Scaffidi, Michela Martin, Sara De Pasut, Gianfranco
Published in
Pharmaceutics
Although selective tumor delivery of anticancer drugs has been sought by exploiting either passive targeting or by ligand-mediated targeting, a selective anticancer therapy remains an unmet medical need. Despite the advances which have been achieved by nanomedicines, nanosystems such as polymer-drug conjugates still miss the goal of clinical effica...
Karava, Vasiliki Siamidi, Aggeliki Vlachou, Marilena Christodoulou, Evi Bikiaris, Nikolaos D Zamboulis, Alexandra Kostoglou, Margaritis Gounari, Eleni Barmpalexis, Panagiotis
Published in
Pharmaceutics
The present study evaluates the use of newly synthesized poly(l-lactic acid)-co-poly(butylene adipate) (PLA/PBAd) block copolymers as microcarriers for the preparation of aripiprazole (ARI)-loaded long acting injectable (LAI) formulations. The effect of various PLA to PBAd ratios (95/5, 90/10, 75/25 and 50/50 w/w) on the enzymatic hydrolysis of the...
Bhonsale, Satyajeet Scott, Lewis Ghadiri, Mojtaba Van Impe, Jan
Published in
Pharmaceutics
Spiral jet mills are ubiquitous in the pharmaceutical industry. Breakage and classification in spiral jet mills occur due to complex interactions between the fluid and the solid phases. The study of these interactions requires the use of computational fluid dynamics (CFD) for the fluid phase coupled with discrete element models (DEM) for the partic...
Tanaudommongkon, Irin Tanaudommongkon, Asama Dong, Xiaowei
Published in
Pharmaceutics
Most antiretroviral medications for human immunodeficiency virus treatment and prevention require high levels of patient adherence, such that medications need to be administered daily without missing doses. Here, a long-acting subcutaneous injection of lopinavir (LPV) in combination with ritonavir (RTV) using in situ self-assembly nanoparticles (IS...
Draksiene, Gailute Venclovaite, Brigita Pudziuvelyte, Lauryna Ivanauskas, Liudas Marksa, Mindaugas Bernatoniene, Jurga
Published in
Pharmaceutics
The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution rate when prepared in tablet press using 10.8 kN an...
Schütt, Michael Stamatopoulos, Konstantinos Batchelor, Hannah K Simmons, Mark J H Alexiadis, Alessio
Published in
Pharmaceutics
For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution. Commonly, the performance of a drug formulation is assessed using standardised dissolution apparatus, which does not replicate the hydrodynamics and shear stress evoked by wall motion i...
