Wakai, Eri Suzumura, Yuya Ikemura, Kenji Mizuno, Toshiro Watanabe, Masatoshi Takeuchi, Kazuhiko Nishimura, Yuhei
Published in
Pharmaceuticals (Basel, Switzerland)
Cisplatin is widely used to treat various types of cancers, but it is often limited by nephrotoxicity. Here, we employed an integrated in silico and in vivo approach to identify potential treatments for cisplatin-induced nephrotoxicity (CIN). Using publicly available mouse kidney and human kidney organoid transcriptome datasets, we first identified...
Borgonetti, Vittoria Les, Francisco López, Víctor Galeotti, Nicoletta
Published in
Pharmaceuticals (Basel, Switzerland)
The long-term use of anxiolytic and antidepressant drugs can cause a plethora of side effects and the use of complementary and alternative medicine, which is generally considered safer than conventional medicine, is consistently increasing. Helichrysum stoechas (L.) Moench methanolic extract (HSE) has shown MAO-A inhibitory properties in previous s...
Dessouki, Fatima Bianca A Kukreja, Rakesh C Singla, Dinender K
Published in
Pharmaceuticals (Basel, Switzerland)
Doxorubicin (Dox)-induced muscle toxicity (DIMT) is a common occurrence in cancer patients; however, the cause of its development and progression is not established. We tested whether inflammation-triggered cell death, "pyroptosis" plays a role in DIMT. We also examined the potential role of exosomes derived from embryonic stem cells (ES-Exos) in a...
Suay-Garcia, Beatriz Falcó, Antonio Bueso-Bordils, J Ignacio Anton-Fos, Gerardo M Pérez-Gracia, M Teresa Alemán-López, Pedro A
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Pharmaceuticals (Basel, Switzerland)
Drug repurposing appears as an increasing popular tool in the search of new treatment options against bacteria. In this paper, a tree-based classification method using Linear Discriminant Analysis (LDA) and discrete indexes was used to create a QSAR (Quantitative Structure-Activity Relationship) model to predict antibacterial activity against Esche...
Frtús, Adam Smolková, Barbora Uzhytchak, Mariia Lunova, Mariia Jirsa, Milan Hof, Martin Jurkiewicz, Piotr Lozinsky, Vladimir I Wolfová, Lucie Petrenko, Yuriy
...
Published in
Pharmaceuticals (Basel, Switzerland)
Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo-Yes-associated protein 1 (YAP) pathways are important mediators of mechanical cues. The crosstalk between these pathways as well as de-regulation of their signaling has been implicated in multiple tumor types, including liver tumors. Additionally, physical c...
Cui, Jianzhou Shen, Han-Ming Lim, Lina Hsiu Kim
Published in
Pharmaceuticals (Basel, Switzerland)
Autophagy is an evolutionarily conserved lysosomal-dependent pathway for degrading cytoplasmic proteins, macromolecules, and organelles. Autophagy-related genes (Atgs) are the core molecular machinery in the control of autophagy, and several major functional groups of Atgs coordinate the entire autophagic process. Autophagy plays a dual role in liv...
Bleasel, Martin D Peterson, Gregory M
Published in
Pharmaceuticals (Basel, Switzerland)
Emetine is a potent antiviral that acts on many viruses in the low-nM range, with several studies in animals and humans demonstrating antiviral activity. Historically, emetine was used to treat patients with Spanish influenza, in the last stages of the pandemic in the early 1900s. Some of these patients were "black" with cyanosis. Emetine rapidly r...
Piras, Anna Maria Zambito, Ylenia Lugli, Maurizio Ferro, Baldassare Roncucci, Paolo Mori, Filippo Salvatore, Alfonso Ascione, Ester Bellini, Marta Crea, Roberto
...
Published in
Pharmaceuticals (Basel, Switzerland)
The SARS-CoV-2 infection is associated with pulmonary coagulopathy, which determines the deposition of fibrin in the air spaces and lung parenchyma. The resulting lung lesions compromise patient pulmonary function and increase mortality, or end in permanent lung damage for those who have recovered from the COVID-19 disease. Therefore, local pulmona...
Bhakta-Guha, Dipita Efferth, Thomas
Published in
Pharmaceuticals (Basel, Switzerland)
In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic fu...
Tam, James P Wang, Shujing Wong, Ka H Tan, Wei Liang
Published in
Pharmaceuticals (Basel, Switzerland)
Plant antimicrobial peptides (AMPs) have evolved differently from AMPs from other life forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the disulfides cross-braced plant AMPs as cystine-rich peptides to confer them with extraordinary high chemical, thermal and proteolytic stability. The cystine-rich or co...
