Lindemann, Marcel Dukic-Stefanovic, Sladjana Hinz, Sonja Deuther-Conrad, Winnie Teodoro, Rodrigo Juhl, Cathleen Steinbach, Jörg Brust, Peter Müller, Christa E Wenzel, Barbara
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Pharmaceuticals (Basel, Switzerland)
The G protein-coupled adenosine A2B receptor is suggested to be involved in various pathological processes accompanied by increased levels of adenosine as found in inflammation, hypoxia, and cancer. Therefore, the adenosine A2B receptor is currently in focus as a novel target for cancer therapy as well as for noninvasive molecular imaging via posit...
Kushikata, Tetsuya Hirota, Kazuyoshi Saito, Junichi Takekawa, Daiki
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Pharmaceuticals (Basel, Switzerland)
Neuropeptide S (NPS) is an endogenous peptide that regulates various physiological functions, such as immune functions, anxiety-like behaviors, learning and memory, the sleep-wake rhythm, ingestion, energy balance, and drug addiction. These processes include the NPS receptor (NPSR1). The NPS-NPSR1 system is also significantly associated with the on...
Halim, Sobia Ahsan Jabeen, Sumaira Khan, Ajmal Al-Harrasi, Ahmed
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Pharmaceuticals (Basel, Switzerland)
α-Glucosidase is considered a prime drug target for Diabetes Mellitus and its inhibitors are used to delay carbohydrate digestion for the treatment of diabetes mellitus. With the aim to design α-glucosidase inhibitors with novel chemical scaffolds, three folds ligand and structure based virtual screening was applied. Initially linear quantitative s...
Shi, Changjing Yao, Yu Wang, Lei Sun, Ping Feng, Jianying Wu, Gang
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Pharmaceuticals (Basel, Switzerland)
The avascular structure and lack of regenerative cells make the repair of osteochondral defects in the temporomandibular joint (TMJ) highly challenging in the clinic. To provide a viable treatment option, we developed a methacrylated gelatin (Gel-MA) hydrogel functionalized with human salivary histatin-1 (Hst1). Gel-MA is highly biocompatible, biod...
Choi, Goeun Piao, Huiyan Rejinold, N Sanoj Yu, Seungjin Kim, Ki-Yeok Jin, Geun-Woo Choy, Jin-Ho
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Pharmaceuticals (Basel, Switzerland)
COVID-19 has been affecting millions of individuals worldwide and, thus far, there is no accurate therapeutic strategy. This critical situation necessitates novel formulations for already existing, FDA approved, but poorly absorbable drug candidates, such as niclosamide (NIC), which is of great relevance. In this context, we have rationally designe...
Kubacka, Monika Mogilski, Szczepan Zadrożna, Monika Nowak, Barbara Szafarz, Małgorzata Pomierny, Bartosz Marona, Henryk Waszkielewicz, Anna Jawień, Wojciech Sapa, Jacek
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Pharmaceuticals (Basel, Switzerland)
Quinazoline α1-adrenoceptors antagonists have been shown to exert moderately favorable effects on the metabolic profile in hypertensive patients. However, based on AntiHypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) results, they are no longer recommended as a first line therapy of hypertension. Recent studies have ...
Morrow, Ryan Funk, Ryan Becker, Mara Sherman, Ashley Van Haandel, Leon Hudson, Taina Casini, Rebecca Shakhnovich, Valentina
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Pharmaceuticals (Basel, Switzerland)
Inside cells, the immunomodulator methotrexate (MTX) undergoes the addition of glutamates to form methotrexate polyglutamates (MTX-Glu)-promising biomarkers of systemic exposure and treatment response to MTX in rheumatology. MTX-Glu are underexplored in Inflammatory Bowel Disease (IBD), with no data in pediatrics. In this cross-sectional secondary ...
Palermiti, Alice Cafaro, Alessia Barco, Sebastiano Bucchioni, Paolo Franceschini, Paolo Cusato, Jessica De Nicolò, Amedeo Manca, Alessandra De Vivo, Elisa Delia Russo, Eleonora
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Pharmaceuticals (Basel, Switzerland)
Medical cannabis is increasingly being used in the treatment and support of several diseases and syndromes. The quantitative determination of active ingredients (delta-9 tetrahydrocannabinol, THC, and cannabidiol, CBD) in galenic oily preparations is prescribed by law for each produced batch. The aim of this work is to describe the organization of ...
Garcia-Oliveira, Paula Otero, Paz Pereira, Antia Gonzalez Chamorro, Franklin Carpena, Maria Echave, Javier Fraga-Corral, Maria Simal-Gandara, Jesus Prieto, Miguel Angel
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Pharmaceuticals (Basel, Switzerland)
Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve mono-chemotherapy or a combination of radiotherapy and mono-chemotherapy. However, the negative side effects of these approaches have been extensively reported and have pro...
Sobańska, Anna W Robertson, Jeremy Brzezińska, Elżbieta
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Pharmaceuticals (Basel, Switzerland)
Several chromatographic parameters (RM0 and S obtained from RP-18 TLC with methanol-pH 7.4 phosphate buffer mobile phases by extrapolation to zero concentration of methanol; Rf and RM obtained from RP-18 TLC with acetonitrile-pH 7.4 phosphate buffer 70:30 v/v as a mobile phase) and calculated molecular descriptors (molecular weight-MW; molar volume...
