Borisova, Boryana Nocheva, Hristina Gérard, Stéphane Laronze-Cochard, Marie Dobrev, Stefan Angelova, Silvia Petrin, Stoyko Danalev, Dancho
Published in
Pharmaceuticals (Basel, Switzerland)
The inflammatory process represents a specific response of the organism's immune system. More often, it is related to the rising pain in the affected area. Independently of its origin, pain represents a complex and multidimensional acute or chronic subjective unpleasant perception. Currently, medical doctors prescribe various analgesics for pain tr...
Joseph, Boney Nunez, Nicolas A Kung, Simon Vande Voort, Jennifer L Pazdernik, Vanessa K Schak, Kathryn M Boehm, Stacey M Carpenter, Brooke Johnson, Emily K Malyshev, Grigoriy
...
Published in
Pharmaceuticals (Basel, Switzerland)
Intravenous (IV) ketamine and FDA-approved intranasal (IN) esketamine are increasingly used for treatment-resistant depression (TRD). Preliminary studies have suggested a synergistic effect of ketamine and lamotrigine, although the data are inconclusive. Herein, we report the response to serial ketamine/esketamine treatment among patients with TRD ...
Šafranko, Silvija Šubarić, Drago Jerković, Igor Jokić, Stela
Published in
Pharmaceuticals (Basel, Switzerland)
Citrus fruits processing results in the generation of huge amounts of citrus by-products, mainly peels, pulp, membranes, and seeds. Although they represent a major concern from both economical and environmental aspects, it is very important to emphasize that these by-products contain a rich source of value-added bioactive compounds with a wide spec...
Zarroug, Samah H O Bajaman, Juhaina S Hamza, Fatheia N Saleem, Rimah A Abdalla, Hana K
Published in
Pharmaceuticals (Basel, Switzerland)
Antimicrobial resistance (AMR) due to the prevalence of multidrug-resistant (MDR) pathogens is rapidly increasing worldwide, and the identification of new antimicrobial agents with innovative mechanisms of action is urgently required. Medicinal plants that have been utilised for centuries with minor side effects may hold great promise as sources of...
Saraiva, Sofia M Jacinto, Telma A Gonçalves, Ana C Gaspar, Dário Silva, Luís R
Published in
Pharmaceuticals (Basel, Switzerland)
Caffeine is a naturally occurring alkaloid found in various plants. It acts as a stimulant, antioxidant, anti-inflammatory, and even an aid in pain management, and is found in several over-the-counter medications. This naturally derived bioactive compound is the best-known ingredient in coffee and other beverages, such as tea, soft drinks, and ener...
Arafat, Mosab Sarfraz, Muhammad Bostanudin, Mohammad F Esmaeil, Anna Salam, Aisha AbuRuz, Salahdein
Published in
Pharmaceuticals (Basel, Switzerland)
Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high permeability and rapid metabolism in the liver can limit the bioavailability and increase the dose frequencies for up to four tim...
Chen, Di Van der Ent, Martijn A Lartey, Nathaniel L King, Philip D
Published in
Pharmaceuticals (Basel, Switzerland)
Ephrin receptors constitute a large family of receptor tyrosine kinases in mammals that through interaction with cell surface-anchored ephrin ligands regulate multiple different cellular responses in numerous cell types and tissues. In the cardiovascular system, studies performed in vitro and in vivo have pointed to a critical role for Ephrin recep...
Gou, Wenyu Wei, Hua Swaby, Lindsay Green, Erica Wang, Hongjun
Published in
Pharmaceuticals (Basel, Switzerland)
Browning of white adipose tissue (WAT) is suggested as a promising therapeutic approach to induce energy expenditure and counteract obesity and its associated complications. Systemic depletion of spinophilin (SPL) increases metabolism and improves energy balance in mice. In this study, we explored the mechanistic insight of SPL action in WAT browni...
Behl, Tapan Rocchetti, Gabriele Chadha, Swati Zengin, Gokhan Bungau, Simona Kumar, Arun Mehta, Vineet Uddin, Md Sahab Khullar, Gaurav Setia, Dhruv
...
Published in
Pharmaceuticals (Basel, Switzerland)
To date, the leading causes of mortality and morbidity worldwide include viral infections, such as Ebola, influenza virus, acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS) and recently COVID-19 disease, caused by the SARS-CoV-2 virus. Currently, we can count on a narrow range of antiviral drugs, especially older g...
Tateo, Valentina Manuzzi, Lisa Parisi, Claudia De Giglio, Andrea Campana, Davide Pantaleo, Maria Abbondanza Lamberti, Giuseppe
Published in
Pharmaceuticals (Basel, Switzerland)
Thymic tumors are a group of rare mediastinal malignancies that include three different histological subtypes with completely different clinical behavior: the thymic carcinomas, the thymomas, and the rarest thymic neuroendocrine tumors. Nowadays, few therapeutic options are available for relapsed and refractory thymic tumors after a first-line plat...
