Houlind, Morten Baltzer Petersen, Kristian Kjær Palm, Henrik Jørgensen, Lillian Mørch Aakjær, Mia Christrup, Lona Louring Petersen, Janne Andersen, Ove Treldal, Charlotte
Published in
Pharmaceuticals (Basel, Switzerland)
Many analgesics and their metabolites are renally excreted. The widely used Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)-estimated glomerular filtration rate (eGFR) equations are not developed for use in the elderly, while the recent Berlin Initiative Study (BIS), Full Age Spectrum (FAS), and Lund-Malmö revised (LMR) equations are. T...
Bhandari, Sunil Pereira, Dora I A Chappell, Helen F Drakesmith, Hal
Published in
Pharmaceuticals (Basel, Switzerland)
Iron is an essential trace mineral necessary for life, and iron deficiency anaemia (IDA) is one of the most common haematological problems worldwide, affecting a sixth of the global population. Principally linked to poverty, malnutrition and infection in developing countries, in Western countries the pathophysiology of IDA is primarily linked to bl...
Szudzik, Mateusz Starzyński, Rafał R Jończy, Aneta Mazgaj, Rafał Lenartowicz, Małgorzata Lipiński, Paweł
Published in
Pharmaceuticals (Basel, Switzerland)
The authors wish to make the following corrections to this paper [¹]: the term "liposomal" should be replaced with the term "sucrosomial" in the following places [...].
Nuñez de Villavicencio-Diaz, Teresa Rabalski, Adam J Litchfield, David W
Published in
Pharmaceuticals (Basel, Switzerland)
Protein kinase CK2 is a small family of protein kinases that has been implicated in an expanding array of biological processes. While it is widely accepted that CK2 is a regulatory participant in a multitude of fundamental cellular processes, CK2 is often considered to be a constitutively active enzyme which raises questions about how it can be a r...
Bhakta-Guha, Dipita Efferth, Thomas
Published in
Pharmaceuticals (Basel, Switzerland)
In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic fu...
Bahar, Ali Adem Liu, Zhigang Garafalo, Meagan Kallenbach, Neville Ren, Dacheng
Published in
Pharmaceuticals (Basel, Switzerland)
Infections caused by multidrug-resistant bacteria have been on the rise. This important issue presents a great challenge to the healthcare system and creates an urgent need for alternative therapeutic agents. As a potential solution to this problem, antimicrobial peptides (AMPs) have attracted increasing attention due to their broad spectrum of tar...
Pokorný, Jiří Pokorný, Jan Foletti, Alberto Kobilková, Jitka Vrba, Jan Vrba, Jan
Published in
Pharmaceuticals (Basel, Switzerland)
Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruva...
Vamecq, Joseph Mention-Mulliez, Karine Leclerc, Francis Dobbelaere, Dries
Published in
Pharmaceuticals (Basel, Switzerland)
Recently, propranolol was suggested to prevent hyperlactatemia in a child with hypovolemic shock through β-adrenergic blockade. Though it is a known inhibitor of glycolysis, propranolol, outside this observation, has never been reported to fully protect against lactate overproduction. On the other hand, literature evidence exists for a cross-talk b...
Thomford, Nicholas E Dzobo, Kevin Chopera, Denis Wonkam, Ambroise Skelton, Michelle Blackhurst, Dee Chirikure, Shadreck Dandara, Collet
Published in
Pharmaceuticals (Basel, Switzerland)
The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the use of herbal medicines. Most African people accept herbal medicines as generally safe with no serious adverse effects. However, t...
Chaki, Shigeyuki Fukumoto, Kenichi
Published in
Pharmaceuticals (Basel, Switzerland)
Recently, ketamine has been demonstrated to exert rapid-acting antidepressant effects in patients with depression, including those with treatment-resistant depression, and this discovery has been regarded as the most significant advance in drug development for the treatment of depression in over 50 years. To overcome unwanted side effects of ketami...
