Wang, Kai Amidon, Gordon L Smith, David E
Published in
Pharmaceutical research
This review is a revisit of various oral drug absorption models developed in the past decades, focusing on how to incorporate the physiological dynamics in the upper gastrointestinal (GI) tract. For immediate-release oral drugs, GI absorption is a critical input of drug exposure and subsequent human body response, yet difficult to model largely due...
Helal, Nada A Martinez, Marilyn N Longstaff, David G Mohamed, Eman M Rahman, Ziyaur Khan, Mansoor A Nutan, Mohammad T H
Published in
Pharmaceutical research
Intramammary (IMM) formulations are locally acting and delivered intracisternally into the udder. No pharmacopeial in-vitro release method is available to differentiate between the IMM formulations. Our research aim is to develop in-vitro release methods that discriminate different IMM formulations (SPECTRAMAST® LC and in-house formulations). Diffe...
Igarashi, Yuki Takemura, Wataru Liu, Xiaoxi Kojima, Nana Morita, Takumi Chuang, Victor Tuan Giam Enoki, Yuki Taguchi, Kazuaki Matsumoto, Kazuaki
Published in
Pharmaceutical research
Nacubactam (NAC) is a novel diazabicyclooctane β-lactamase inhibitor used in combination with cefepime (CFPM). In this study, we aimed to determine the target pharmacokinetics (PK) and pharmacodynamics (PD) values of CFPM/NAC in mice infected with β-lactamase-producing Enterobacterales, such as the carbapenemase-producing Enterobacterales. Three st...
Tchessalov, Serguei Maglio, Vito Kazarin, Petr Alexeenko, Alina Bhatnagar, Bakul Sahni, Ekneet Shalaev, Evgenyi
Published in
Pharmaceutical research
The purpose of this paper is to re-visit the design of three steps in the freeze-drying process, namely freezing, primary drying, and secondary drying steps. Specifically, up-to-date recommendations for selecting freeze-drying conditions are provided based on the physical-chemical properties of formulations and engineering considerations. This pape...
Jourdain, Rubens Chivukula, Venkat Keshav Bashur, Chris A
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Pharmaceutical research
Vascular cognitive impairment and dementia results from blood components passing through disrupted blood brain barriers (BBBs). Current treatments can reduce further progress of neuronal damage but do not treat the primary cause. Instead, these treatments typically aim to temporarily disrupt the BBB. Alternatively, this study computationally assess...
Rahman, Sadia Haque, Tasmima N Sugandhi, Vrashabh V Saraswat, Aishwarya L Xin, Xiaoban Cho, Hyunah
Published in
Pharmaceutical research
In this study, nanogel creams carrying paclitaxel (PTX) and temozolomide (TMZ) were prepared for the topical treatment of melanoma. PTX and TMZ were first loaded in poly-(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly-(D,L-lactide-co-glycolide) (PLAG-b-PEG-b-PLGA) thermosensitive nanogels, which made a transition from a free-flowi...
Macias-Moriarity, Lilia Z Sinclair, Starlette M Walker, Doretha Purnell, Miriam
Published in
Pharmaceutical research
Impostor phenomenon (IP), grit, and other factors impact job satisfaction for faculty, particularly female faculty. The Impostor Phenomenon Research Collaborative (IPRC) evaluated IP, grit, and job satisfaction in pharmacy faculty. A cross-sectional study was conducted with a convenience sample of faculty using a survey, which included demographic ...
Khanolkar, Asmita White, Susie Margerison, Elizabeth
Published in
Pharmaceutical research
Healthcare trends continue to move from hospital to home and many targeted therapies and precision medicines are now being designed to be self-administered by patients or delivered in a home setting. In the case of long acting injectables and bio-therapeutics, the importance of optimal drug/biologic-device combination in terms of user needs becomes...
Tao, Yeqing Chen, Yuan Howard, Wesley Ibrahim, Mariam Patel, Sajal M McMahon, William P Kim, Yoen Joo Delmar, Jared A Davis, Darryl
Published in
Pharmaceutical research
Spray-drying is considered a promising alternative drying method to lyophilization (freeze-drying) for therapeutic proteins. Particle counts in reconstituted solutions of dried solid dosage forms of biologic drug products are closely monitored to ensure product quality. We found that high levels of particles formed after reconstitution of protein p...
Mousa, Ahmed Bakr Moawad, Raghda Abdallah, Yasmine Abdel-Rasheed, Mazen Zaher, Azza M Abdel
Published in
Pharmaceutical research
Ovarian cancer is the most lethal cancer in gynaecology. Surgery, chemotherapy, and radiotherapy are the most often used cancer-fighting strategies. Post-surgery infection is fairly prevalent, especially among people with insufficient immunity. Zinc oxide nanoparticles (ZnOnps) have amazing biomedical features as anticancer and antibacterial agents...
