Ayari, Gillian d’Huart, Elise Vigneron, Jean Demoré, Béatrice
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Patients hospitalized in intensive care units often require multiple drug infusions. Due to limited intravenous accesses, concomitant administration of drugs in the same infusion line is often necessary. Compatibility studies of Y-site administration are available in the literature, but data of several combinations are lacking. Previous ...
Heeb, Rita Marina Erdnüß, Frank Reichhold, Julia Krämer, Irene
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives In adult intensive care patients, epinephrine is mostly administered by continuous injection with syringe pumps. The objective of this study was to investigate the physicochemical stability of pharmacy prepared ready-to-use epinephrine (E) 0.02 mg/mL injection solutions (total volume 50 mL) for assigning shelf-life. Methods E 0.02 mg/mL ...
Erdnüß, Frank Mohr, André Krämer, Irene
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives The objective of this study was to investigate the physicochemical stability of ready-to-adminster human insulin (HI) 1 I.U./mL injection solutions of two different brand products diluted with 0.9% NaCl solution under different storage conditions either in 50 mL disposable plastic syringes or as bulk solution in infusion bags. Methods HI...
Carpentier, Thomas Maillard, Eve Royer, Mathilde Mustapha, Lina Marçon, Frédéric
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Amongst paediatric pharmaceutical forms, syrups offer advantages such as ease of administration and good palatability. They also exhibited microbial self-preservation properties that may be useful to enhance shelf life of liquid formulation. The objective of our works is to test the self-preservation efficacy of maltitol and glucose syru...
Farcy, Elisabeth Bui, Duc Tâm Lebel, Denis Bussières, Jean-François
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives The aim of this study was to review studies describing the use and the impact of technology-assisted workflow (TAWF) systems for drug compounding in hospital pharmacy. Content This is a scoping literature review. A search was conducted on studies describing or evaluating the use of TAWF published from January 1st, 2015 to July 31st, 2021...
Delafoy, Clémence Chabut, Claire Tanguay, Cynthia Bussières, Jean-François
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives To evaluate the efficacy of two decontamination protocols on cyclophosphamide surface contamination and to explore its lasting effect 30 days later. Methods All sampling sites that were systematically contaminated with cyclophosphamide in 2017–2020 were included, from a convenience sample of centers. The first decontamination protocol co...
Gagaille, Marie-Pauline Pieragostini, Rémi Girault, Elise Touil, Yacine Chalopin, Marie Besse, Michael Pons-Kerjean, Nathalie
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Preparation of injectable anticancer drugs in hospital pharmacies, in particular of cytotoxics, is a high-risk activity. We used Preliminary Risk Analysis (PRA) to analyse the risks in the different steps of our anticancer drug circuit, including the preparation step (PRA1). Then, to prepare an important change in management of the circu...
Mohr, André Erdnüß, Frank Krämer, Irene
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives The objective of this study was to investigate the physicochemical stability of human insulin 1 I.U./mL injection solutions (Insuman® Rapid) diluted with 0.9% NaCl solution in 50 mL disposable three-piece polypropylene syringes and stored refrigerated or at room temperature. Methods 1 I.U./mL test solutions were prepared with Insuman® Ra...
Rase, Marissa Hanlon, Mark Ho, Le Duriez, Doug Zhao, Cathy
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Particles due to fragmentation present a clear risk to the patient. Reported fragmentation rates vary, and an insertion angle at 45°, as opposed to 90°, has been proposed as a mitigation strategy. So, this study evaluated the fragmentation rates induced by single-use hypodermic needles using different angled penetration techniques. Metho...
Abu Abed, Omar S. Mulkala, Srilikha Sharif, Israa Abdin, Asma M. Elkordy, Amal A.
Published in
Pharmaceutical Technology in Hospital Pharmacy
Objectives Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposo...
