Matheron, Agnès Guerault, Marie-Noelle Vazquez, Raphael Cheron, Mireille Brossard, Denis Crauste-Manciet, Sylvie
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Pharmaceutical Technology in Hospital Pharmacy
Objectives The objectives were to assess the microbiological stability and the physical enclosure integrity of the overwrapping for batch production of standard cytotoxic injectable solutions. Methods Broth culture media were used in place of cytotoxic drugs to assess the worst case in term of microbiological contamination risk. Iterative sterility...
Schmitt, Camille Fouque, Julien Blondeel-Gomes, Sandy Provost, Claire Da Costa Branquinho, Emilie Madar, Olivier
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Pharmaceutical Technology in Hospital Pharmacy
Introduction To reduce costs of gallium-68 activity in nuclear medicine, a subcontracting activity has been settled for [68Ga]Ga-edotreotide preparations. Cold kits are radiolabeled in our radiopharmacy and shipped out to nearby hospitals. According to the Summary of Product Characteristics (SmPC), preparations must be stored below 25 °C until expi...
Merienne, Camille Marchand, Chloe Filali, Samira Salmon, Damien Pivot, Christine Pirot, Fabrice
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Pharmaceutical Technology in Hospital Pharmacy
Background Stability of low amoxicillin oral dosage form (5 mg) used in reintroduction drug test was not fully documented. Furthermore, the impact of (1) salt moiety of amoxicillin and (2) amoxicillin – excipient interactions upon the antibiotic formulation stability during the storage was not characterized so that the estimation of the pharmaceuti...
Di-Falco, Elodie Bourbon, Johan Sbaffe, Isalyne Kaiser, Jean-Daniel
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Pharmaceutical Technology in Hospital Pharmacy
Alsace, in particular Haut-Rhin, is one of the main clusters of COVID-19 in France. There has been a shortage of essential supplies in the area, especially alcohol-based hand sanitizer. In this context, and in accordance with the decree dated March 6, 2020, our hospital management team asked us to start local production of alcohol-based handrub. Th...
Villain, Alexandre Sakji, Ilyes Bogart, Emilie Strobbe, Geoffrey Marliot, Guillaume Feutry, Frédéric
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Pharmaceutical Technology in Hospital Pharmacy
Objectives Preparation of 5-FU elastomeric pumps is a time-consuming activity inducing musculoskeletal disorders (MSDs). Our unit has developed an automated filling system consisting of two peristaltic pumps (one for the diluent, one for the cytotoxic drug). The objective was to validate the accuracy of the assembly and evaluate the impact of autom...
Sangnier, Maïté Bouguéon, Guillaume Berroneau, Aude Dubois, Véronique Crauste-Manciet, Sylvie
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Pharmaceutical Technology in Hospital Pharmacy
In the context of batch production of cytotoxic drugs in hospital pharmacies with the need of sterility testing, the objective was to validate the use of Rapid Microbiological Method (RMM), and to develop adequate neutralization method in case of inhibition of bacterial growth. The potential microbiological growth inhibitory effect of three antican...
Chennell, Philip Tokhadzé, Nicolas Sautou, Valérie
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Pharmaceutical Technology in Hospital Pharmacy
Objectives Infliximab diluted solutions have been shown to be physicochemically stable for long periods, however the adsorption of infliximab during infusions has not been readily investigated. This study aimed to evaluate potential adsorption phenomena of infliximab during administration through Polyvinylchloride (PVC) and Polyurethane (PU) infusi...
Léa, De Neef Damien, Peyronnet Blondeel-Gomes, Sandy
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Pharmaceutical Technology in Hospital Pharmacy
In the context of securing medication management systems (MMS) in healthcare habilities, implementation of an electronic MMS is a priority area of work. The quality requirements for the production of radiopharmaceuticals have increased significantly in the field of radiopharmacy. The deployment of Information Technology (IT) tools is essential to s...
Hausherr, Anne Roessle, Clara Pinet, Emma Vasseur, Véronique Abarou, Tarik Benakouche, Samira Bourdon, Olivier Storme, Thomas
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Pharmaceutical Technology in Hospital Pharmacy
Objectives Drugs are developed for adults, making it difficult to find suitable treatments for children. Hospital pharmacy has developed alternatives to respond to this medical need. The objective of this study is to present a new liquid formulation of ursodeoxycholic acid (UDCA) at a concentration suitable for treatment of neonatal jaundice, and t...
Crauste-Manciet, Sylvie Krämer, Irene Lagarce, Frederic Sautou, Valerie Beaney, Alison Smith, Julian Fenton-May, V’Iain Hecq, Jean-Daniel Sadeghipour, Farshid Brun, Paul Le
...
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Pharmaceutical Technology in Hospital Pharmacy
All dosage forms prepared in hospital pharmacies should be labelled with an appropriate shelf-life. This shelf-life should be validated taking chemical, physical and microbiological data into consideration. This guidance focuses on parenteral aseptically prepared products, as they are high-risk preparations. The risk is exacerbated by a requirement...
