Robelet, Antoine Guimier-Pingault, Catherine Lambert, Christophe
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Pharmaceutical Technology in Hospital Pharmacy
Sterilization is a pharmaceutical discipline constantly evolving and requiring highly qualified staff. In response to the need highlighted by French sterilization heads, the French Society for Sterilization Science (SF2S) has developed a serious game called “SteriDefiTM”. To design the game, a literature review was carried out in order to determine...
Vigneron, Jean D’Huart, Elise Demoré, Béatrice
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Pharmaceutical Technology in Hospital Pharmacy
Background Bendamustine is used for the treatment of non-Hodgkin lymphoma, chronic lymphocytic leukaemia and myeloma. The stability of bendamustine is highly dependent on temperature and chloride-ion concentration. Limited stability data are available. The objective of this work was to study the stability of the bendamustine reconstituted solution ...
Bellay, Romain Bonnaure, Anne-Claire Rault, Pauline Pertuisel, Sophie Lester, Marie-Antoinette Boivin, Pierre-Nicolas
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Pharmaceutical Technology in Hospital Pharmacy
Background Nitrendipine is prescribed to children for the treatment of primary hypertension (off-label use). Available specialties (Nidrel®, Baypress® and others generic drugs) are only marketed in tablet form, which is unsuitable for pediatric use. A hospital preparation of nitrendipine oral suspension at 5 mg/mL was developed. The aim of the stud...
Godet, Marie Simar, Joanna Closset, Mélanie Hecq, Jean-Daniel Braibant, Maximilien Soumoy, Laura Gillet, Patricia Jamart, Jacques Bihin, Benoît Galanti, Laurence
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Pharmaceutical Technology in Hospital Pharmacy
Background Vancomycin is increasingly administrated by continuous infusion. But the treatment of patient in intensive care need restricted volume to prevent fluid overload. The aim of the study was to evaluate the physical and chemical stability of solutions of a high concentration of vancomycin hydrochloride in 5 % glucose or 0.9 % NaCl. Methods E...
Lagarce, Frederic
Published in
Pharmaceutical Technology in Hospital Pharmacy
D’Huart, Elise Lider, Pauline Vigneron, Jean Demoré, Béatrice
Published in
Pharmaceutical Technology in Hospital Pharmacy
Background Stabilis® is an international database on stability and compatibility of drugs. The stability data comes mainly from publications of pharmaceutical journals. As the quality of the published stability studies is not equivalent, the objective of this work was to propose a level of evidence for the physico-chemical stability studies selecte...
Vigneron, Jean
Published in
Pharmaceutical Technology in Hospital Pharmacy
Le Basle, Yoann Chennell, Philip Sautou, Valérie
Published in
Pharmaceutical Technology in Hospital Pharmacy
Preservative free ophthalmic formulations need to be packaged either as single doses, or using specially designed sterility preserving multidose eyedroppers. Our objective was to evaluate potential sorption phenomena between a device with a silicone sterility preserving membrane and the delivered drops of several ophthalmic solutions. Cyclosporine,...
Binson, Guillaume Venisse, Nicolas Bacle, Astrid Beuzit, Karine Dupuis, Antoine
Published in
Pharmaceutical Technology in Hospital Pharmacy
Background Dexamethasone is commonly used to treat a wide variety of diseases including oncological disorders. The aim of this study was to propose a liquid formulation of dexamethasone. Therefore we have developed and assessed the stability of a 5 mg/mL dexamethasone oral suspension. Methods A stability-indicating analytical method, using HPLC-UV,...
Robert, Julien Sorrieul, Jérémy Kieffer, Hélène Folliard, Caroline Gibory, Vincent Dupoiron, Denis Devys, Catherine
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Pharmaceutical Technology in Hospital Pharmacy
Background The association of morphine and baclofen is used for the treatment of spasticity related pain. Moving these patients is sometimes difficult. In order to transport these syringes for pump refilling, it could be interesting to demonstrate the stability of the mixture, and so to be able to ensure the best transport conditions of syringes. M...
