Royer, Mathilde Libessart, Maïté Dubaele, Jean-Marc Tourneux, Pierre Marçon, Fréderic
Published in
Pharmaceutical Technology in Hospital Pharmacy
Parenteral nutrition (PN) in the neonatal intensive care unit (NICU) involves a succession of risky processes. The objective was to identify and prioritize the risks associated with PN in order to improve the quality of the pathway. A failure modes, effects, and criticality analysis (FMECA) was used to identify potential PN pathway failure modes. A...
Palamini, Marie Mercier, Geneviève Bussières, Jean-François
Published in
Pharmaceutical Technology in Hospital Pharmacy
Background In the hospital setting, trace contamination with hazardous medications comes primarily from the manipulation of containers used in preparing and administering drugs. However, some traces of medications also come from the excreta of patients. Methods This descriptive exploratory study involved direct observation and discussion. The aim w...
Curti, Christophe Mathias, Fanny Savelli, Morane Garrigue, Philippe Lamy, Edouard Guillet, Benjamin Vanelle, Patrice
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Pharmaceutical Technology in Hospital Pharmacy
Background Carbidopa is a drug mainly used to treat Parkinson’s disease. Associations with levodopa or with levodopa/entacapone are commercialized, but there is no oral formulation of carbidopa alone available in Europe. As carbidopa can also be used as premedication of adult patients for insulinoma diagnosis, it must be compounded as single dose m...
Hecq, Jean-Daniel Krämer, Irene Vigneron, Jean
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Pharmaceutical Technology in Hospital Pharmacy
In hospitals, the majority of medication therapy is administered intravenously. Especially, in intensive care units, simultaneous of various injectable drugs is a common practice Drug incompatibilities have been reported to be associated with up to 60 % of all serious and life-threatening adverse drug events. Several databases are used by hospital ...
Bourbon, Johan Dory, Anne Perello, Laurent Belotti, Laure Reisz, Fanny Ubeaud-Sequier, Genevieve Gourieux, Bénédicte
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Pharmaceutical Technology in Hospital Pharmacy
Background Urea is recommended in the 2nd line treatment in moderate to severe hyponatraemia induced by syndrome of inappropriate antidiuretic hormone secretion (SIADH), when water restriction is insufficient. A posology of 0.25–0.5 g/kg daily is suggested. A usual but inadequate urea oral preparation, i. e. 10 g urea powder dissolved in 100 mL wat...
Soumoy, Laura Hecq, Jean-Daniel
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Pharmaceutical Technology in Hospital Pharmacy
Automated compounding systems appeared on the market during these last 15 years as an alternative for manual compounding of intravenous (IVD) drugs. A literature review was conducted on reconstitution of IVD. The following methods were identified: manual, semi- automatic and automatic. A classification was carried out in three categories: automatic...
Painchart, Lucie Palamini, Marie Odou, Pascal Bussières, Jean-François
Published in
Pharmaceutical Technology in Hospital Pharmacy
Background The preparation of many drugs intended for parenteral administration is centralized in the pharmacy of healthcare institutions. However, no data are available describing the range of drugs with centralized preparation. The objective was to establish a profile of centralization practices for the preparation of non-hazardous drug doses in ...
Sautou, Valérie Lagarce, Frédéric
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Pharmaceutical Technology in Hospital Pharmacy
This opinion paper describes the discussions of the attendees of the last GERPAC European conference workshop on the question of chemical stability and container-content interactions. Pharmacists discussed the steps to implement to carry out those studies that are particulary important to asses the quality of the compounded preparations in hospital...
Nilsson, Niklas Nezvalova-Henriksen, Katerina Tho, Ingunn
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Pharmaceutical Technology in Hospital Pharmacy
Background Propofol and remifentanil often need to be co-administered via the same intravenous catheter line, which predisposes to potential compatibility issues. Our aim was to determine and compare the emulsion stability of three propofol formulations, two with medium chain triglycerides and one with long chain triglycerides, when administered to...
Lagarce, Frederic
Published in
Pharmaceutical Technology in Hospital Pharmacy
