Xu, Ying Xu, Wen Liu, Wei Chen, Gaofeng Jiang, Shili Chen, Jiamei Jian, Xun Zhang, Hua Liu, Ping Mu, Yongping
...
Published in
Pharmaceutical biology
Our previous studies indicated that Yiguanjian decoction (YGJ) has an anti-hepatic-fibrosis effect and could regulate macrophage status. To elucidate the mechanism of YGJ in regulating macrophages. Liver cirrhosis was induced by CCl4 for 12 weeks combined with 2-acetylaminofluorene (2-AAF) for the last 4 weeks in male Wistar rats. YGJ (3.56 mg/kg) ...
Li, Ge Zhang, Chuang Liang, Wei Zhang, Yanbing Shen, Yunheng Tian, Xinhui
Published in
Pharmaceutical biology
Berberine (BBR) is used to treat diarrhoea and gastroenteritis in the clinic. It was found to have anticolon cancer effects. To study the anticolon cancer mechanism of BBR by connectivity map (CMAP) analysis. CMAP based mechanistic prediction was conducted by comparing gene expression profiles of 10 μM BBR treated MCF-7 cells with that of clinical ...
Cui, Yue Wang, Yongqiang Liu, Gang
Published in
Pharmaceutical Biology
Context Epigallocatechin gallate (EGCG) is the most abundant catechin from tea. Previous studies have indicated EGCG has a cardioprotective effect. Objective This manuscript mainly explores the role of EGCG in pressure-overload cardiac hypertrophy and its mechanism related to the Akt/mTOR pathway. Methods and methods Transverse aortic constriction ...
Xue, Weimin Li, Yaqiang Zhang, Mei
Published in
Pharmaceutical Biology
Context Sepsis is a systemic inflammatory disease; pristimerin exhibits strong antibacterial, anti-inflammatory and antioxidant properties. Objectives We explored whether pristimerin protected against cognitive dysfunction and neuroinflammation in C57BL/6 J mice with sepsis-induced brain injuries. Materials and methods Sepsis was induced by intrape...
Wang, Yucheng Xue, Beibei Wang, Xiaoli Wang, Qilong Liu, Erwei Chen, Xiaopeng
Published in
Pharmaceutical Biology
Context Tangwang Mingmu granule (TWMM), a traditional Chinese medicine, has been widely used in the treatment of diabetic retinopathy (DR), the most common microvascular complication in diabetes mellitus. Objective To establish a method to select target compounds from herbs for a pharmacokinetic study using network pharmacology, which could be appl...
Sun, Xiujiang Li, Peng Qu, Xiaoyi Liu, Wenguang
Published in
Pharmaceutical Biology
Context The prevalence of gout has greatly increased, and it has become the most common inflammatory arthritis in men. Isovitexin possesses anti-inflammatory and antioxidant properties. Objective We explored the effects of isovitexin on rats with acute gouty arthritis (GA). Materials and methods Fifty-four Sprague-Dawley rats were assigned to five ...
Yang, Zhang-Jie Wang, Yu-Xin Zhao, Shuai Hu, Na Chen, Dong-Mei Ma, Hui-Ming
Published in
Pharmaceutical Biology
Context Lycium barbarum L. (Solanaceae) seed oil (LBSO) exerts LBSO exerts protective effects in the testis in vivo and in vitro via upregulating SIRT3. Objective This study evaluates the effects and mechanism of LBSO in the d -galactose ( d -gal)-induced ageing testis. Materials and methods Male Sprague Dawley (SD) rats ( n = 30, 8-week-old) were ...
Chen, Shu-yi Zhang, Gao-chen-xi Shu, Qi-jin
Published in
Pharmaceutical Biology
Context Yang-Yin-Jie-Du Decoction (YYJDD) was used to improve gefitinib efficacy in our clinical practice, but its mechanism remains unclear. Objective This study explored if YYJDD could reverse gefitinib resistance. Materials and methods H1975 cells were exposed to control, 10 μM gefitinib, 3.2 mg/mL YYJDD or combination treatment. Cell viability ...
Guo, Sitong Li, Yan Su, Henghai Meng, Mingyu Xi, Jiaxi Mo, Guangyan Chen, Xiaoyu
Published in
Pharmaceutical Biology
Context Aidi injection is one of the most commonly use antitumor Chinese medicine injections for advanced non-small cell lung cancer (NSCLC). It is made from the extraction of Astragalus, Eleutherococcus senticosus, Ginseng , and Cantharis. Objective To evaluate the efficacy and safety of Aidi injection in combination with gemcitabine-based chemoth...
Zhang, Hui Dong, Wenwen Li, Siyuan Zhang, Yunqian Lv, Zhou Yang, Lu Jiang, Lai Wu, Tao Wang, Yan
Published in
Pharmaceutical Biology
Context Salidroside, a compound extracted from Rhodiola rosea L. (Crassulaceae), possesses many beneficial pathological effects. Objective To explore the effect of salidroside on ventilator-induced lung endothelial dysfunction in vivo and in vitro . Materials and methods In vivo , male ICR mice were divided into sham, ventilation, salidroside, and ...
