Sun, Yueshan Wu, Anguo Li, Xiu Qin, Dalian Jin, Bingjin Liu, Jian Tang, Yong Wu, Jianming Yu, Chonglin
Published in
Pharmaceutical biology
Context: The seed of Litchi chinensis Sonn., a famous traditional Chinese medicine, was recently reported to enhance cognitive function by inhibiting neuronal apoptosis in rats.Objective: We determined whether the seed of Litchi chinensis fraction (SLF) can ameliorate hippocampal neuronal injury via the AKT/GSK-3β pathway.Materials and methods: We ...
He, Shou-Di Huang, Sheng-Guang Zhu, Hui-Jun Luo, Xiao-Guang Liao, Kang-Han Zhang, Jie-Yao Tan, Ning Li, De-Yu
Published in
Pharmaceutical biology
Context: Oridonin exhibits various pharmacological and physiological activities, including antioxidant, antibacterial, anti-inflammatory, pro-apoptotic, anticancer and neurological effects. However, its role in rheumatoid arthritis (RA) is yet to be revealed.Objective: We evaluated the effects of oridonin on the survival and autophagy of RA-fibrobl...
Fatemi, Farzaneh Abdollahi, Mohammad Reza Mirzaie-Asl, Asghar Dastan, Dara Papadopoulou, Kalliope
Published in
Pharmaceutical biology
Context: Satureja khuzistanica Jamzad. (Lamiaceae), is known for its antifungal and antioxidant compounds, especially rosmarinic acid (RA).Objective: The study examines the effect of elicitors on RA production and phytochemical properties of S. khuzistanica.Materials and methods: In vitro plants were treated with methyl jasmonate (MeJA) and multi-w...
Si, Yanpo Wang, Lili Lan, Jinxu Li, Hanwei Guo, Tao Chen, Xiaohui Dong, Chunhong Ouyang, Zhen Chen, Sui-Qing
Published in
Pharmaceutical biology
Lilium davidii var. unicolour Cotton (Lilium genus, Liliaceae) is an edible plant and a herb used in China to alleviate insomnia. To investigate the alleviating insomnia mechanism of L. davidii (LD). Wistar rats were intraperitoneally injected with p-chlorophenylalanine (PCPA) to establish an insomnia model. Rats were divided into six groups (n = 8...
Wang, Zhaohui Chen, Zhi Li, Bingsheng Zhang, Bo Du, Yongchao Liu, Yuhang He, Yao Chen, Xiang
Published in
Pharmaceutical biology
Renal interstitial fibrosis (RIF) is characterized by the accumulation of inflammatory cytokines and epithelial-mesenchymal transition (EMT). Curcumin exerts antifibrogenic, anti-inflammatory and antiproliferative effects. To explore the mechanisms underlying the effects of curcumin on RIF. Eight-week-old male C57BL/6 mice were intragastrically adm...
Xu, Shangchen Zhang, Fengqing Chen, Dali Su, Keren Zhang, Li Jiang, Rui
Published in
Pharmaceutical biology
Context: Ganoderic acid A (GAA) is usually used to prevent cancers or other diseases, which make it likely to be used with other drugs metabolized by cytochromes P450.Objective: This study investigates the effect of GAA on eight major cytochrome P450 isoforms in human liver microsomes.Material and method: The effects of GAA (100 μM) on eight human ...
Zheng, Hong Huang, Wenya He, Bing Tan, Hongchang Lin, Pingzhi Zha, Zhengang
Published in
Pharmaceutical biology
Context: Sanguisorba officinalis L. (Rosaceae), a famous traditional Chinese medicine. It was recently reported that its polysaccharide could facilitate collagen production.Objectives: We investigated the mechanism by which S. officinalis polysaccharide (SOWPa) and/or platelet-rich plasma (PRP) promote regenerative potential of anterior cruciate li...
Zhang, Zhiqin Bai, Jie Zeng, Yawen Cai, Mengru Yao, Yu Wu, Huimin You, Longtai Dong, Xiaoxv Ni, Jian
Published in
Pharmaceutical biology
Acetylshikonin, a naphthoquinone derivative, is mainly extracted from some species of the family Boraginaceae, such as Lithospermum erythrorhizon Sieb. et Zucc., Arnebia euchroma (Royle) Johnst., and Arnebia guttata Bunge. As a bioactive compound, acetylshikonin has attracted much attention because of its broad pharmacological properties. This revi...
Ren, Pei-Hua Zhang, Zhi-Min Wang, Peng Zhu, Han-Ping Li, Zhen-Qiu
Published in
Pharmaceutical biology
Context: Acute myocardial infarction (AMI) is defined as myocardial necrosis. Clinicians use the traditional Chinese patent medicine Yangxinkang Tablet (YXK) to treat chronic heart failure.Objective: To explore the effects of YXK on heart injury following AMI and the underlying mechanisms.Materials and methods: The AMI model was produced in Wistar ...
Zhao, Xin Xu, Baoxin Wu, Peng Zhao, Pan Guo, Changchuan Cui, Yueli Zhang, Yanxue Zhang, Xuelan Li, Huifen
Published in
Pharmaceutical biology
Sibiricose A5 (A5), sibiricose A6 (A6), 3,6'-disinapoyl sucrose (DSS), tenuifoliside A (TFSA) and 3,4,5-trimethoxycinnamic acid (TMCA) are the main active components of Polygala tenuifolia Willd. (Polygalaceae) (PT) that are active against Alzheimer's disease. To compare the pharmacokinetics and bioavailability of five active components in the root...
