Al-Sroji, Rouba Yasser Al-Laham, Shaza Almandili, Ahmad
Published in
Pharmaceutical biology
Vancomycin (VCM), an important antibiotic against refractory infections, has been used to treat secondary infections in severe COVID-19 patients. Regrettably, VCM treatment has been associated with nephrotoxicity. Vitamin D3 can prevent nephrotoxicity through its antioxidant effect. This study tests the antioxidant effect of vitamin D3 in the preve...
Wen, Yong Zhan, Yu Tang, Shiyu Liu, Fang Wu, Rong Kong, Pengfei Li, Qian Tang, Xuegui
Published in
Pharmaceutical biology
Slow transit constipation (STC), the most common type of constipation, seriously affects the life of patients. Zhizhu decoction (ZZD), a traditional Chinese medicine compound, has is effective against functional constipation, but the mechanism is still unclear. This research explores the mechanism of ZZD on STC from the perspective of metabolomics ...
Goli, Arman Syah Sato, Vilasinee Hirunpanich Sato, Hitoshi Chewchinda, Savita Leanpolchareanchai, Jiraporn Nontakham, Jannarin Yahuafai, Jantana Thilavech, Thavaree Meesawatsom, Pongsatorn Maitree, Metawee
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Published in
Pharmaceutical biology
Lysiphyllum strychnifolium (Craib) A. Schmitz (LS) (Fabaceae) has traditionally been used to treat diabetes mellitus. This study demonstrates the antidiabetic and antioxidant effects of aqueous extract of LS leaves in vivo and in vitro. The effects of aqueous LS leaf extract on glucose uptake, sodium-dependent glucose cotransporter 1 (SGLT1) and gl...
Wang, Fan Liu, Chang Ren, LingZhi Li, YanYang Yang, HongMei Yu, Yang Xu, WeiPing
Published in
Pharmaceutical biology
Sanziguben (SZGB) is an empirical prescription used in traditional Chinese medicine to treat diabetic nephropathy (DN). As an abundant and primarily effective component of SZGB, Sanziguben polysaccharides (SZP) can be digested by flora to generate biological activity. Our study aimed to clarify the potential mechanism of SZP in improving chronic DN...
Gong, Difei Yuan, Tianyi Wang, Ranran Sun, Shuchan Dawuti, Awaguli Wang, Shoubao Du, Guanhua Fang, Lianhua
Published in
Pharmaceutical biology
Dan-Shen Decoction, which is composed of Danshen, Tanxiang and Sharen, has a good therapeutic effect on ischemic heart disease (IHD). However, systematic research on the exact mechanism of action of Dan-Shen Decoction is still lacking. The anti-IHD effect of Dan-Shen Decoction was examined in this study using a systematic pharmacological method. Th...
Qi, Xiaoyi Chen, Yonglan Liu, Sha Liu, Li Yu, Zehui Yin, Ling Fu, Lu Deng, Mingming Liang, Sicheng Lü, Muhan
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Published in
Pharmaceutical biology
Sanguinarine (SAG) is the most abundant constituent of Macleaya cordata (Willd.) R. Br. (Popaceae). SAG has shown antimammary and colorectal metastatic effects in mice in vivo, suggesting its potential for cancer chemotherapy. To determine the antimetastatic effect and underlying molecular mechanisms of SAG on melanoma. CCK8 assay was used to deter...
Chen, Ting Zhang, Yulong Chen, Manyun Yang, Pu Wang, Yi Zhang, Wei Huang, Weihua Zhang, Wei
Published in
Pharmaceutical biology
The Tongmai Yangxin pill (TMYX) has potential clinical effects on no-reflow (NR); however, the effective substances and mechanisms remain unclear. This study evaluates the cardioprotective effects and molecular mechanisms of TMYX against NR. We used a myocardial NR rat model to confirm the effect and mechanism of action of TMYX in alleviating NR. S...
Liu, Ruiyi Sun, Yan Di, Dong Zhang, Xiyuan Zhu, Boran Wu, Haoxin
Published in
Pharmaceutical biology
Previously, we found Alisma orientalis beverage (AOB), a classic traditional Chinese medicine (TCM) formulation, had the potential effect of treating atherosclerosis (AS). The underlying mechanism was still unclear. As an extention of our previous work, to investigate the underlying mechanism of action of AOB in the treatment for AS. Network pharma...
Liu, Xiaowen Yuan, Lin Tang, Yishuang Wu, Yue Kong, Jing Zhou, Bingduo Wang, Xiaosu Lin, Min Li, Yading Xu, Gaofan
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Published in
Pharmaceutical biology
Da-Cheng-Qi Decoction (DCQD) has a significant effect on Severe Acute Pancreatitis-Associated Acute Lung Injury (SAP-ALI). To explore the mechanism of DCQD in the treatment of SAP-ALI based on intestinal barrier function and intestinal lymphatic pathway. Forty-five Sprague-Dawley rats were divided into three groups: sham operation, model, and DCQD....
Elhefni, Nada Ebada, Sherif S Abdel-Aziz, Marwa M Marwan, El-Sayed M El-Sharkawy, Saleh El-Neketi, Mona
Published in
Pharmaceutical biology
Date palm waste is an agricultural waste that accumulates in massive amounts causing serious pollution and environmental problems. Date palm trees, Phoenix dactylifera Linn CV 'Zaghloul' (Arecaceae) grown in Egypt, leave behind waste products that were investigated to produce compounds with anti-Helicobacter pylori and anti-inflammatory activities....
