Verkhratsky, Alexei Augusto-Oliveira, Marcus Pivoriūnas, Augustas Popov, Alexander Brazhe, Alexey Semyanov, Alexey
Published in
Pflugers Archiv : European journal of physiology
Astroglia represent a class of heterogeneous, in form and function, cells known as astrocytes, which provide for homoeostasis and defence of the central nervous system (CNS). Ageing is associated with morphological and functional remodelling of astrocytes with a prevalence of morphological atrophy and loss of function. In particular, ageing is asso...
Vecchio, Fabrizio Miraglia, Francesca Rodella, Claudia Alù, Francesca Miniussi, Carlo Rossini, Paolo Maria Pellicciari, Maria Concetta
Published in
Pflugers Archiv : European journal of physiology
Brain neural networks undergo relevant changes during physiological aging, which affect cognitive and behavioral functions. Currently, non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), are proposed as tools able to modulate cognitive functions in brain aging, acting on networks properties and connect...
Rennison, Julie H Li, Ling Lin, Cheryl R Lovano, Beth S Castel, Laurie Wass, Sojin Youn Cantlay, Catherine C McHale, Meghan Gillinov, A Marc Mehra, Reena
...
Published in
Pflugers Archiv : European journal of physiology
Atrial fibrillation (AF) is strongly associated with risk of stroke and heart failure. AF promotes atrial remodeling that increases risk of stroke due to left atrial thrombogenesis, and increases energy demand to support high rate electrical activity and muscle contraction. While many transcriptomic studies have assessed AF-related changes in mRNA ...
Simard, Christophe Magaud, Christophe Adjlane, Racim Dupas, Quentin Sallé, Laurent Manrique, Alain Bois, Patrick Faivre, Jean-François Guinamard, Romain
Published in
Pflugers Archiv : European journal of physiology
Cardiac fibroblasts play an important role in cardiac matrix turnover and are involved in cardiac fibrosis development. Ca2+ is a driving belt in this phenomenon. This study evaluates the functional expression and contribution of the Ca2+-activated channel TRPM4 in atrial fibroblast phenotype. Molecular and electrophysiological investigations were ...
Gaburjakova, Jana Krejciova, Eva Gaburjakova, Marta
Published in
Pflugers Archiv : European journal of physiology
Many proteins are phosphorylated at more than one phosphorylation site to achieve precise tuning of protein function and/or integrate a multitude of signals into the activity of one protein. Increasing the number of phosphorylation sites significantly broadens the complexity of molecular mechanisms involved in processing multiple phosphorylation si...
Jiang, Chuan Dong, Ning Feng, Jianli Hao, Maolin
Published in
Pflugers Archiv : European journal of physiology
Ischemic stroke is an urgent public health concern and one of the major causes of deaths and disabilities over the world. MicroRNA (miRNA) has become a key mediator of cerebral ischemia-reperfusion (I/R) injuries. However, whether miR-190 is involved in cerebral I/R-induced neuronal damage remains unknown. This study was to investigate the role of ...
Schnoz, Christina Moser, Sandra Kratschmar, Denise V Odermatt, Alex Loffing-Cueni, Dominique Loffing, Johannes
Published in
Pflugers Archiv : European journal of physiology
The renal distal convoluted tubule (DCT) is critical for the fine-tuning of urinary ion excretion and the control of blood pressure. Ion transport along the DCT is tightly controlled by posttranscriptional mechanisms including a complex interplay of kinases, phosphatases, and ubiquitin ligases. Previous work identified the transcription factor Prox...
Lagatta, Davi C Kuntze, Luciana B Uliana, Daniela L Borges-Assis, Anna B Resstel, Leonardo B M
Published in
Pflugers Archiv : European journal of physiology
The bed nucleus of the stria terminalis (BNST) is a forebrain structure, involved in the modulation of neuroendocrine, cardiovascular and autonomic responses. One of the responses is baroreflex activity, which consists in a neural mechanism responsible for keeping the blood pressure within a narrow range of variation. It has been reported that bloc...
Martínez-Ramírez, Carmen Gil-Gómez, Irene G de Diego, Antonio M García, Antonio G
Published in
Pflugers Archiv : European journal of physiology
Pre-blockade of the sarco-endoplasmic reticulum (ER) calcium ATPase (SERCA) with irreversible thapsigargin depresses exocytosis in adrenal bovine chromaffin cells (BCCs). Distinct expression of voltage-dependent Ca2+-channel subtypes and of the Ca2+-induced Ca2+ release (CICR) mechanism in BCCs versus mouse chromaffin cells (MCCs) has been describe...
Hernández-Cruz, Arturo
Published in
Pflugers Archiv : European journal of physiology
