A rare cause of nephrocalcinosis in an infant: Answers
Published in Pediatric Nephrology
Efficacy and safety of an innovative prolonged-release combination drug in patients with distal renal tubular acidosis: ...
...Published in Pediatric Nephrology
BackgroundDistal renal tubular acidosis (dRTA), due to impaired acid secretion in the urine, can lead to severe long-term consequences. Standard of care (SoC) oral alkalizers, requiring several daily intakes, are currently used to restore normal plasma bicarbonate levels. A new prolonged-release formulation, ADV7103, has been developed to achieve a...
Clinical practice recommendations for the diagnosis and management of Alport syndrome in children, adolescents, and youn...
Published in Pediatric Nephrology
In 2013, we published a set of clinical practice recommendations for the treatment of Alport syndrome in this journal. We recommended delaying the initiation of angiotensin-converting enzyme inhibition until the onset of overt proteinuria or, in some cases, microalbuminuria. Developments that have occurred over the past 7 years have prompted us to ...
Aortic dilatation in children with mild to moderate chronic kidney disease
Published in Pediatric Nephrology
BackgroundChildren with mild to moderate chronic kidney disease are at an increased risk for cardiovascular sequelae, the leading cause of death in children with end-stage renal disease. We aimed to establish the prevalence of aortic dilatation, a newly recognized cardiovascular sequelae of renal disease, within a cohort of pediatric patients with ...
Multiple office blood pressure measurement: a novel approach to overcome the weak cornerstone of blood pressure measurem...
...Published in Pediatric Nephrology
BackgroundThis contribution aims to report and analyze a novel approach for office blood pressure measurement in children.MethodsHealthy children 5 to 8 years of age were eligible. After 5 minutes rest, 10 unattended blood pressure readings were taken at 3-minute intervals using a validated automated oscillometric device. After discarding outlier v...
Malaria and acute kidney injury
Published in Pediatric Nephrology
Malaria is a parasitic infection transmitted by mosquitos, resulting in significant morbidity and mortality. It affects 212 million worldwide, causing death in up to 303,000 children annually. In the USA, up to 1700 people are affected yearly. Although the prevalence in developed countries is less than in developing countries, travelers from low tr...
Acute kidney injury in hospitalized children: consequences and outcomes
Published in Pediatric Nephrology
Over the past decade, the nephrology and critical care communities have adopted a consensus approach to diagnosing acute kidney injury (AKI) and, as a result, we have seen transformative changes in our understanding of pediatric AKI epidemiology. The data regarding outcomes among neonates and children who develop AKI have become far more robust and...
Eplet mismatch analysis and allograft outcome across racially diverse groups in a pediatric transplant cohort: a single-...
Published in Pediatric Nephrology
HLA eplet mismatch load has been suggested as an improvement to HLA antigen mismatch determination for organ selection. Given that eplet mismatches are determined based on amino acid sequence difference among HLA alleles, and that the frequency of HLA alleles varies between racial groups, we investigated the correlation between eplet mismatch load ...
Clostridium difficile infection after pediatric solid organ transplantation: a practical single-center experience
Published in Pediatric Nephrology
BackgroundDuring the last two decades, there has been a worldwide increase in frequency and severity of infections with Clostridium difficile (CDI). Solid organ transplant (SOT) recipients receiving immunosuppressing medications are especially at risk.MethodsWe collected data from immunocompromised pediatric patients, including kidney and liver tra...
Renal stone and chronic kidney failure associated with hypouricemia: Questions
Published in Pediatric Nephrology
