Kuznik, B I Bogdanov, I G Isakova, N V Serebrijskij, I I Kas'janenko, N V
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
In the preoperative period ischemic patients show a significant increase in thrombodynamic properties of fibrin clots. It is more than at a half of patients in the presurgical period as in an arterial, and venus blood the spontaneous growth of a clot comes to light that is practically not observed at healthy people. In the early postoperative perio...
Vasiljeva, N N Bryndina, I G Protasova, S V Butolin, E G
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
It is shown that the surface active properties of lung under experimental diabetes mellitus was decreased on the background of increased LPL content in alveolar space. Surfactant changes correlated with the level of glucose, glycosylated hemoglobin and 11-oxycorticosteroids in blood. The obtained results indicate that the degree of impairment in th...
Reschetniak, V K Kukushkin, M L Gurko, N S
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
This review presents the current data in the literature about the importance of the cortex and subcortical structures of the brain in the perception of acute and chronic pain. Discussed the importance of various areas of the brain in perception discriminative and affective components of pain. Discusses also gender differences in pain perception dep...
Lebedeva, M A Karganov, M Yu Kozlova, Y A Gotovtceva, G N Tumurov, D A Gudkova, A A Guekht, A B
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
This article presents the results of a comparative study of autonomic disorders in patients with differernt types of irritable bowel syndrome (IBS). We used several clinical and instrumental methods, including the Veyn questionnaire, Kerdo autonomic index, skin sympathetic response and heart rate variability analysis. The results show a prevalence ...
Titov, V N
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
Metabolic syndrome (overeating) is a phylogenetically-determined succession of symptoms with the same pathogenesis. There is only one etiological factor, namely, increased consumption of physiologically optimal food. Enterocytes and omental fat cells are a phylogenetically early paracrine-regulated cell community that realizes the biological reacti...
Alekseeva, E V Sal'nikov, P S
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
HCS or NGS condition is characteristic for patients in extremely critical condition (with APACHE II 30 (24; 38)). Conjunction of glutamate (Gl) and its' biochemical metabolism indicators maintenance alterations in peripheral blood, small intestine EA parameters and 28-day survival rates in RD shows the participation of glutamatergic system in patho...
Sergeeva, S P Litvickiy, P F Breslavich, I D Gultyaev, M M
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
The goal of the present study was to investigate the plasma levels of sTNF-alpha, sTNF-R1 in acute stroke patients, to study the relation between ones, the neurological stroke severity and functional disability. The investigations comprised 60 ischemic stroke patients, 25 patients form control group. Plasma levels of sTNF-alpha, sTNF-R1 were detect...
Grebnev, D U
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
The objective of this work was to study the influence of combined transplantation of stem cells (multypotent mesenchimal stromal and hem poetic stem cells) on the haemopoesis of old and mature laboratory animals under the condition of ionizing radiation. The experiments were conducted on 48 white male mice with the body weight of 30 g, age of 3-4 m...
Ivanov, V V Shakhristova, E V Stepovaya, E A Nosareva, O L Fedorova, T S Novitsky, V V
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
Analysis of modern literature data as well as the results of personal research on development of oxidative stress in adipose tissue in diabetes is presented. Mechanisms of modulation of spontaneous and induced lipolysis in adipocytes in conditions of oxidative stress are discussed. Participation of adipose tissue in forming insulin resistance in ty...
Strizhevskaya, A M Senzhapova, E R Dzamraev, A Z Baykova, V N
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Patologicheskaia fiziologiia i èksperimental'naia terapiia
High-dose methotrexate blocks the metabolic pathways of conversion of homocysteine to methionine. As a result, homocysteine (hcy) accumulates in the blood. The aim of this study was to determine the relationship between changes in concentrations of hcy, mtx, and other criteria of toxicity in the key hours of therapeutic drug monitoring of mtx, as w...
