Zhang, Rui Chen, Shen Chen, Liping Ye, Lizhu Jiang, Yue Peng, Hui Guo, Zhanyu Li, Miao Jiang, Xinhang Guo, Ping
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Published in
Particle and Fibre Toxicology
Background Long-term exposure to fine particulate matter (PM2.5) increases susceptibility to chronic respiratory diseases, including inflammation and interstitial fibrosis. However, the regulatory mechanisms by which the immune response mediates the initiation of pulmonary fibrosis has yet to be fully characterized. This study aimed to illustrate t...
Ho, Chia-Chi Wu, Wei-Te Lin, Yi-Jun Weng, Chen-Yi Tsai, Ming-Hsien Tsai, Hui-Ti Chen, Yu-Cheng Yet, Shaw-Fang Lin, Pinpin
Published in
Particle and Fibre Toxicology
Background Exposure to ambient fine particulate matter (PM2.5) is associated with vascular diseases. Polycyclic aromatic hydrocarbons (PAHs) in PM2.5 are highly hazardous; however, the contribution of PM2.5-bound PAHs to PM2.5-associated vascular diseases remains unclear. The ToxCast high-throughput in vitro screening database indicates that some P...
Guilloteau, Eva Coll, Patrice Lu, Zhuyi Djouina, Madjid Cazaunau, Mathieu Waxin, Christophe Bergé, Antonin Caboche, Ségolène Gratien, Aline Al Marj, Elie
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Published in
Particle and fibre toxicology
Emerging data indicate that prenatal exposure to air pollution may lead to higher susceptibility to several non-communicable diseases. Limited research has been conducted due to difficulties in modelling realistic air pollution exposure. In this study, pregnant mice were exposed from gestational day 10-17 to an atmosphere representative of a 2017 p...
Areecheewakul, Sudartip Adamcakova-Dodd, Andrea Haque, Ezazul Jing, Xuefang Meyerholz, David K. O’Shaughnessy, Patrick T. Thorne, Peter S. Salem, Aliasger K.
Published in
Particle and Fibre Toxicology
Background It has been shown that copper oxide nanoparticles (CuO NPs) induce pulmonary toxicity after acute or sub-acute inhalation exposures. However, little is known about the biodistribution and elimination kinetics of inhaled CuO NPs from the respiratory tract. The purposes of this study were to observe the kinetics of pulmonary inflammation d...
Mittag, Anna Singer, Alina Hoera, Christian Westermann, Martin Kämpfe, Alexander Glei, Michael
Published in
Particle and fibre toxicology
Zinc oxide nanoparticles (ZnO NP) offer beneficial properties for many applications, especially in the food sector. Consequently, as part of the human food chain, they are taken up orally. The toxicological evaluation of orally ingested ZnO NP is still controversial. In addition, their physicochemical properties can change during digestion, which l...
Hojo, Motoki Maeno, Ai Sakamoto, Yoshimitsu Ohnuki, Aya Tada, Yukie Yamamoto, Yukio Ikushima, Kiyomi Inaba, Ryota Suzuki, Jin Taquahashi, Yuhji
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Published in
Particle and Fibre Toxicology
Background A mounting number of studies have been documenting the carcinogenic potential of multiwalled carbon nanotubes (MWCNTs); however, only a few studies have evaluated the pulmonary carcinogenicity of MWCNTs in vivo. A 2-year inhalation study demonstrated that MWNT-7, a widely used MWCNT, was a pulmonary carcinogen in rats. In another 2-year ...
Jalili, Pégah Krause, Benjamin-Christoph Lanceleur, Rachelle Burel, Agnès Jungnickel, Harald Lampen, Alfonso Laux, Peter Luch, Andreas Fessard, Valérie Hogeveen, Kevin
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Published in
Particle and fibre toxicology
TiO2 nanomaterials (NMs) are present in a variety of food and personal hygiene products, and consumers are exposed daily to these NMs through oral exposition. While the bulk of ingested TiO2 NMs are eliminated rapidly in stool, a fraction is able to cross the intestinal epithelial barrier and enter systemic circulation from where NMs can be distrib...
McNeilly, Ryan J. Schwanekamp, Jennifer A. Hyder, Logan S. Hatch, John P. Edwards, Brett T. Kirsh, Jacob A. Jackson, Jerimiah M. Jaworek, Thomas Methner, Mark M. Duran, Christin M.
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Published in
Particle and Fibre Toxicology
Background Since the introduction of copper based, lead-free frangible (LFF) ammunition to Air Force small arms firing ranges, instructors have reported symptoms including chest tightness, respiratory irritation, and metallic taste. These symptoms have been reported despite measurements determining that instructor exposure does not exceed establish...
Takeda, Tomoki Yamano, Shotaro Goto, Yuko Hirai, Shigeyuki Furukawa, Yusuke Kikuchi, Yoshinori Misumi, Kyohei Suzuki, Masaaki Takanobu, Kenji Senoh, Hideki
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Published in
Particle and Fibre Toxicology
Gupta, Govind Cappellini, Francesca Farcal, Lucian Gornati, Rosalba Bernardini, Giovanni Fadeel, Bengt
Published in
Particle and Fibre Toxicology
Background Copper oxide (CuO) nanoparticles (NPs) are known to trigger cytotoxicity in a variety of cell models, but the mechanism of cell death remains unknown. Here we addressed the mechanism of cytotoxicity in macrophages exposed to CuO NPs versus copper chloride (CuCl2). Methods The mouse macrophage cell line RAW264.7 was used as an in vitro mo...
