Coméra, Christine Cartier, Christel Gaultier, Eric Catrice, Olivier Panouille, Quentin El Hamdi, Sarah Tirez, Kristof Nelissen, Inge Théodorou, Vassilia Houdeau, Eric
...
Published in
Particle and Fibre Toxicology
BackgroundFood-grade TiO2 (E171 in the EU) is widely used as a coloring agent in foodstuffs, including sweets. Chronic dietary exposure raises concerns for human health due to proinflammatory properties and the ability to induce and promote preneoplastic lesions in the rodent gut. Characterization of intestinal TiO2 uptake is essential for assessin...
Ding, Yaobo Weindl, Patrick Lenz, Anke-Gabriele Mayer, Paula Krebs, Tobias Schmid, Otmar
Published in
Particle and Fibre Toxicology
BackgroundAccurate knowledge of cell−/tissue-delivered dose plays a pivotal role in inhalation toxicology studies, since it is the key parameter for hazard assessment and translation of in vitro to in vivo dose-response. Traditionally, (nano-)particle toxicological studies with in vivo and in vitro models of the lung rely on in silio computational ...
Lee, Dong-Keun Jeon, Soyeon Jeong, Jiyoung Song, Kyung Seuk Cho, Wan-Seob
Published in
Particle and Fibre Toxicology
BackgroundThe quantification of nanomaterials accumulated in various organs is crucial in studying their toxicity and toxicokinetics. However, some types of nanomaterials, including carbon nanomaterials (CNMs), are difficult to quantify in a biological matrix. Therefore, developing improved methodologies for quantification of CNMs in vital organs i...
Xu, Jing Yang, Junyao Chen, Jian Zhang, Xiaoli Wu, Yuanhao Hart, Alister Nyga, Agata Shelton, Julia C.
Published in
Particle and Fibre Toxicology
BackgroundThe toxicity of released metallic particles generated in metal-on-metal (MoM) total hip arthroplasty (THA) using cobalt chromium (CoCr) has raised concerns regarding their safety amongst both surgeons and the public. Soft tissue changes such as pseudotumours and metallosis have been widely observed following the use of these implants, whi...
Chen, Yu-Chen Chuang, Tzu-Yi Liu, Chen-Wei Liu, Chi-Wei Lee, Tzu-Lin Lai, Tsai-Chun Chen, Yuh-Lien
Published in
Particle and Fibre Toxicology
BackgroundParticulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress increased the expression of proinflammatory intracellular adhesion molecule-1 (ICAM-1) through the IL-6/AKT/STAT3/NF-κB pathway in A...
Coyle, Jayme P. Derk, Raymond C. Kornberg, Tiffany G. Singh, Dilpreet Jensen, Jake Friend, Sherri Mercer, Robert Stueckle, Todd A. Demokritou, Philip Rojanasakul, Yon
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Published in
Particle and Fibre Toxicology
BackgroundEngineered nanomaterials are increasingly being incorporated into synthetic materials as fillers and additives. The potential pathological effects of end-of-lifecycle recycling and disposal of virgin and nano-enabled composites have not been adequately addressed, particularly following incineration. The current investigation aims to chara...
Wu, Rongrong Högberg, Johan Adner, Mikael Ramos-Ramírez, Patricia Stenius, Ulla Zheng, Huiyuan
Published in
Particle and Fibre Toxicology
BackgroundRespirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and if new cases can be avoided by lowered permissible exposure levels. In this study we investigate early DNA damaging effects of low d...
Bendtsen, Katja Maria Gren, Louise Malmborg, Vilhelm Berg Shukla, Pravesh Chandra Tunér, Martin Essig, Yona J. Krais, Annette M. Clausen, Per Axel Berthing, Trine Loeschner, Katrin
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Published in
Particle and Fibre Toxicology
BackgroundDiesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 ...
Holme, Siri A. N. Sigsgaard, Torben Holme, Jørn A. Holst, Gitte Juel
Published in
Particle and Fibre Toxicology
BackgroundExposure to air pollution has been associated with adverse effects on human health, and ultimately increased morbidity and mortality. This is predominantly due to hazardous effects on the cardiovascular system. Exposure to particulate matter (PM) is considered to be responsible for the most severe effects.Main bodyHere we summarize curren...
Chen, Yu-Wen Huang, Mei-Zi Chen, Chyi-Liang Kuo, Chieh-Ying Yang, Chia-Yu Chiang-Ni, Chuan Chen, Yi-Ywan M. Hsieh, Chia-Ming Wu, Hui-Yu Kuo, Ming-Ling
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Published in
Particle and Fibre Toxicology
BackgroundPneumococcus is one of the most common human airway pathogens that causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM2.5) is known to significantly contribute to respiratory diseases. PM2.5-induced airway inflammation may decrease innate immune defenses against bacterial infecti...
