Annangi, Balasubramanyam Lu, Zhuyi Bruniaux, Jonathan Ridoux, Audrey da Silva, Vanessa Marques Vantelon, Delphine Boczkowski, Jorge Lanone, Sophie
Published in
Particle and Fibre Toxicology
BackgroundCerium (Ce) is a rare earth element, rapidly oxidizing to form CeO2, and currently used in numerous commercial applications, especially as nanoparticles (NP). The potential health effects of Ce remain uncertain, but literature indicates the development of rare earth pneumoconiosis accompanied with granuloma formation, interstitial fibrosi...
Jin, Xiaoting Yu, Haiyi Zhang, Ze Cui, Tenglong Wu, Qi Liu, Xiaolei Gao, Jie Zhao, Xingchen Shi, Jianbo Qu, Guangbo
...
Published in
Particle and Fibre Toxicology
Background Considering the inevitability for humans to be frequently exposed to nanoparticles (NPs), understanding the biosafety of NPs is important for rational usage. As an important part of the innate immune system, macrophages are widely distributed in vital tissues and are also a dominant cell type that engulfs particles. Mitochondria are one ...
Young, Tamara L Mostovenko, Ekaterina Denson, Jesse L Begay, Jessica G Lucas, Selita N Herbert, Guy Zychowski, Katherine Hunter, Russell Salazar, Raul Wang, Ting
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Published in
Particle and fibre toxicology
Multiwalled carbon nanotubes (MWCNT) are an increasingly utilized engineered nanomaterial that pose the potential for significant risk of exposure-related health outcomes. The mechanism(s) underlying MWCNT-induced toxicity to extrapulmonary sites are still being defined. MWCNT-induced serum-borne bioactivity appears to dysregulate systemic endothel...
Gopinath, Ponnusamy Manogaran Twayana, Krishna Sundar Ravanan, Palaniyandi John Thomas, Mukherjee, Amitava Jenkins, David F Chandrasekaran, Natarajan
Published in
Particle and fibre toxicology
Today, cosmetic products are very popular with both men and women to improve their appearance and increase their social acceptability. In this study, nano-sized (30-300 nm) plastic particles were isolated from the commercial face-scrubs and treated on the human keratinocytes. The observed adherence of polyethylene nano-plastics (PENPs), polystyrene...
Camaioni, Antonella Massimiani, Micol Lacconi, Valentina Magrini, Andrea Salustri, Antonietta Sotiriou, Georgios A Singh, Dilpreet Bitounis, Dimitrios Bocca, Beatrice Pino, Anna
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Published in
Particle and fibre toxicology
Metal oxide nanoparticles (NPs) are increasingly used in many industrial and biomedical applications, hence their impact on occupational and public health has become a concern. In recent years, interest on the effect that exposure to NPs may exert on human reproduction has grown, however data are still scant. In the present work, we investigated wh...
Gulumian, Mary Cassee, Flemming R.
Published in
Particle and Fibre Toxicology
Safe-by-Design (SbD) has been put forward as a concept to assure that only safe nanomaterials will reach the market and that safety aspects have already been considered in a very early stage of the innovation process. In practice, several laboratory test have been proposed to screen newly developed nanomaterials and nano-enabled products to assess ...
Ke, Shaorui Liu, Qi Zhang, Xinlian Yao, Yuhan Yang, Xudong Sui, Guodong
Published in
Particle and Fibre Toxicology
Background Exposure to indoor air pollution from solid fuel combustion is associated with lung diseases and cancer. This study investigated the cytotoxicity and molecular mechanisms of biomass combustion-derived particles in human pulmonary alveolar epithelial cells (HPAEpiC) using a platform that combines air–liquid interface (ALI) and dynamic cul...
Shin, Tae Hwan Lee, Da Yeon Manavalan, Balachandran Basith, Shaherin Na, Yun-Cheol Yoon, Cheolho Lee, Hyeon-Seong Paik, Man Jeong Lee, Gwang
Published in
Particle and Fibre Toxicology
BackgroundNanoparticles have been studied for brain imaging, diagnosis, and drug delivery owing to their versatile properties due to their small sizes. However, there are growing concerns that nanoparticles may exert toxic effects in the brain. In this study, we assessed direct nanotoxicity on microglia, the resident macrophages of the central nerv...
Cosnier, Frédéric Seidel, Carole Valentino, Sarah Schmid, Otmar Bau, Sébastien Vogel, Ulla Devoy, Jérôme Gaté, Laurent
Published in
Particle and Fibre Toxicology
BackgroundAn important aspect of nanomaterial (NM) risk assessment is establishing relationships between physicochemical properties and key events governing the toxicological pathway leading to adverse outcomes. The difficulty of NM grouping can be simplified if the most toxicologically relevant dose metric is used to assess the toxicological dose-...
Bian, Yiying Chung, Han-Young Bae, Ok-Nam Lim, Kyung-Min Chung, Jin-Ho Pi, Jingbo
Published in
Particle and Fibre Toxicology
BackgroundExpanding biomedical application of anatase titanium dioxide (TiO2) nanoparticles (NPs) is raising the public concern on its potential health hazards. Here, we demonstrated that TiO2 NPs can increase phosphatidylserine (PS) exposure and procoagulant activity of red blood cells (RBCs), which may contribute to thrombosis.ResultsWe conducted...
