Fu, Yong Lu, Xiao Zhu, Feng Zhao, Yunxiang Ding, Yan Ye, Lilin Guo, Bo Liu, Taiping Xu, Wenyue
Published in
Parasite immunology
A whole-killed malaria blood-stage vaccine (WKV) is promising in reducing the morbidity and mortality of malaria patients, but its efficacy needs to be improved. We found that the antimalarial drug chloroquine could augment the protective efficacy of the WKV of Plasmodium yoelii. The direct antimalarial effect of chloroquine on parasites during imm...
Soares, Roberta Reis Cunha, Clarissa F Ferraz-Nogueira, Raquel Marins-Dos-Santos, Alessandro Rodrigues-da-Silva, Rodrigo Nunes da Silva Soares, Irene da Costa Lima-Junior, Josué Bertho, Alvaro Luiz Ferreira, Marcelo Urbano Scopel, Kézia Katiani Gorza
...
Published in
Parasite immunology
Plasmodium falciparum-specific antibodies tend to be short-lived, but their cognate memory B cells (MBCs) circulate in the peripheral blood of exposed subjects for several months or years after the last infection. However, the time course of antigen-specific antibodies and B-cell responses to the relatively neglected parasite Plasmodium vivax remai...
Chico, Martha E Vaca, Maritza G Rodriguez, Alejandro Cooper, Philip J
Published in
Parasite immunology
There is considerable interest as to potential protective effects of soil-transmitted helminths (STH) against allergy and allergic diseases. Here, we discuss findings of studies done of the effects of STH parasites on atopy and allergic diseases in Ecuador. While cross-sectional studies have consistently shown a reduced prevalence of allergen skin ...
Caraballo, Luis Acevedo, Nathalie Zakzuk, Josefina
Published in
Parasite immunology
Ascariasis is the most frequent soil transmitted helminthiasis and, as well as other helminth infections, is expected to influence the clinical presentation of allergic diseases such as asthma. Indeed, several clinical and experimental works have shown an important impact either increasing or suppressing symptoms, and the same effects have been det...
de Andrade, Candace M Carneiro, Valdirene L Cerqueira, Jéssica V Fonseca, Hellen F Queiroz, Gerson A Costa, Ryan S Alcantara-Neves, Neuza M Cooper, Philip Figueiredo, Camila A
Published in
Parasite immunology
Brazil is a middle-income country undergoing the epidemiological transition. Effects of changes in daily life habits and access to clean water, sanitation and urban services on a growing urban population have contributed to a double burden of both infectious and noncommunicable chronic diseases. Studies have indicated that parasite infections may m...
Mpairwe, Harriet Amoah, Abena S
Published in
Parasite immunology
Population studies from the African continent have observed a marked increase in the prevalence of allergy-related diseases over the past few decades, but the cause of this rise is not fully understood. The most investigated potential risk factor has been the relationship between exposure to helminths and allergy-related outcomes. Immunologically, ...
McSorley, Henry J Chayé, Mathilde A M Smits, Hermelijn H
Published in
Parasite immunology
Type 2 immune responses are most commonly associated with allergy and helminth parasite infections. Since the discovery of Th1 and Th2 immune responses more than 30 years ago, models of both allergic disease and helminth infections have been useful in characterizing the development, effector mechanisms and pathological consequences of type 2 immune...
Cardoso, Thiago Bezerra, Caroline Medina, Lilian Silva Ramasawmy, Rajendranath Scheriefer, Albert Bacellar, Olívia de Carvalho, Edgar M
Published in
Parasite immunology
The polymorphism observed in Leishmania braziliensis is associated with different clinical forms of leishmaniasis. Neutrophils (PMNs) participate in the pathogenesis of leishmania infection, and here, we evaluate neutrophil function after infection with isolates of L. braziliensis from cutaneous leishmaniasis (CL) or disseminated leishmaniasis (DL)...
Dewals, Benjamin G Layland, Laura E Prazeres da Costa, Clarissa Horsnell, William G
Published in
Parasite immunology
Helminth infections leave a long-lasting immunological footprint on their hosts. Clinical studies have provided first evidence that maternal helminth infections can result in an altered immune profile in their offspring which can potentially shape how they respond to conditions throughout life. This can relate to changes in offspring induction of i...
Khanmohammadi, Majid Falak, Reza Meamar, Ahmad Reza Razmjou, Elham Mokhtarian, Kobra Arshadi, Mehdi Shayanfar, Nasrin Akhlaghi, Lame
Published in
Parasite immunology
Dirofilariasis is a zoonotic global vector-borne disease caused by Dirofilaria immitis. The present study focuses on the somatic and excretory/secretory (E/S) proteins released from adult D. immitis. We aimed to fractionate and identify adult D. immitis immunoreactive proteins. Somatic and E/S extracts were immunoblotted to identify the immunoreact...
