Silao, Fitz Gerald S Jiang, Tong Bereczky-Veress, Biborka Kühbacher, Andreas Ryman, Kicki Uwamohoro, Nathalie Jenull, Sabrina Nogueira, Filomena Ward, Meliza Lion, Thomas
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PLoS pathogens
Candida albicans, the primary etiology of human mycoses, is well-adapted to catabolize proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth. We report that put1-/- and put2-/- strains, carrying defective Proline UTilization genes, display remarkable proline sensitivity with put2-/- mutants being hypersensiti...
Tsebriy, Oleksiy Khomiak, Andrii Miguel-Blanco, Celia Sparkes, Penny C Gioli, Maurizio Santelli, Marco Whitley, Edgar Gamo, Francisco-Javier Delves, Michael J
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PLoS pathogens
Preventing parasite transmission from humans to mosquitoes is recognised to be critical for achieving elimination and eradication of malaria. Consequently developing new antimalarial drugs with transmission-blocking properties is a priority. Large screening campaigns have identified many new transmission-blocking molecules, however little is known ...
Medica, Samuel Crawford, Lindsey B Denton, Michael Min, Chan-Ki Jones, Taylor A Alexander, Timothy Parkins, Christopher J Diggins, Nicole L Streblow, Gabriel J Mayo, Adam T
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PLoS pathogens
Human cytomegalovirus (HCMV) encodes multiple putative G protein-coupled receptors (GPCRs). US28 functions as a viral chemokine receptor and is expressed during both latent and lytic phases of virus infection. US28 actively promotes cellular migration, transformation, and plays a major role in mediating viral latency and reactivation; however, know...
Pasquarelli, Rebecca R Back, Peter S Sha, Jihui Wohlschlegel, James A Bradley, Peter J
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PLoS pathogens
The inner membrane complex (IMC) of Toxoplasma gondii is essential for all phases of the parasite's life cycle. One of its most critical roles is to act as a scaffold for the assembly of daughter buds during replication by endodyogeny. While many daughter IMC proteins have been identified, most are recruited after bud initiation and are not essenti...
Krenz, Björn Fuchs, Marc Thompson, Jeremy R
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PLoS pathogens
Motyčková, Alžběta Voleman, Luboš Najdrová, Vladimíra Arbonová, Lenka Benda, Martin Dohnálek, Vít Janowicz, Natalia Malych, Ronald Šuťák, Róbert Ettema, Thijs J G
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PLoS pathogens
Mitochondrial metabolism is entirely dependent on the biosynthesis of the [4Fe-4S] clusters, which are part of the subunits of the respiratory chain. The mitochondrial late ISC pathway mediates the formation of these clusters from simpler [2Fe-2S] molecules and transfers them to client proteins. Here, we characterized the late ISC pathway in one of...
Aguilar-Calvo, Patricia Malik, Adela Sandoval, Daniel R Barback, Christopher Orrù, Christina D Standke, Heidi G Thomas, Olivia R Dwyer, Chrissa A Pizzo, Donald P Bapat, Jaidev
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PLoS pathogens
Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet how HS impacts fibrillar plaque growth within the brain is unclear. Here we found that prion-bound HS chains are highly sulf...
Amin, Mohammed Badrul Talukdar, Prabhat Kumar Asaduzzaman, Muhammad Roy, Subarna Flatgard, Brandon M Islam, Md Rayhanul Saha, Sumita Rani Sharker, Yushuf Mahmud, Zahid Hayat Navab-Daneshmand, Tala
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PLoS pathogens
[This corrects the article DOI: 10.1371/journal.ppat.1010952.]. Copyright: © 2023 Amin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Daniel, Lina Counoupas, Claudio Bhattacharyya, Nayan D Triccas, James A Britton, Warwick J Feng, Carl G
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PLoS pathogens
Recruiting large numbers of naïve lymphocytes to lymph nodes is critical for mounting an effective adaptive immune response. While most naïve lymphocytes utilize homing molecule L-selectin to enter lymph nodes, some circulating cells can traffic to the lung-draining mediastinal lymph node (mLN) through lymphatics via the intermediate organ, lung. H...
Wei, Jin Alfajaro, Mia Madel Cai, Wesley L Graziano, Vincent R Strine, Madison S Filler, Renata B Biering, Scott B Sarnik, Sylvia A Patel, Sonam Menasche, Bridget L
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PLoS pathogens
Identification of host determinants of coronavirus infection informs mechanisms of pathogenesis and may provide novel therapeutic targets. Here, we demonstrate that the histone demethylase KDM6A promotes infection of diverse coronaviruses, including SARS-CoV, SARS-CoV-2, MERS-CoV and mouse hepatitis virus (MHV) in a demethylase activity-independent...