Qiu, Huifang Li, Yuanhao Yuan, Min Chen, Huali Dandekar, Ajai A Dai, Weijun
Published in
PLoS pathogens
XRE-cupin family proteins containing an DNA-binding domain and a cupin signal-sensing domain are widely distributed in bacteria. In Pseudomonas aeruginosa, XRE-cupin transcription factors have long been recognized as regulators exclusively controlling cellular metabolism pathways. However, their potential functional roles beyond metabolism regulati...
Yuan, Wen Chen, Xi Du, Kaitong Jiang, Tong Li, Mengfei Cao, Yanyong Li, Xiangdong Doehlemann, Gunther Fan, Zaifeng Zhou, Tao
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Published in
PLoS pathogens
Papain-like cysteine proteases (PLCPs) play pivotal roles in plant defense against pathogen invasions. While pathogens can secrete effectors to target and inhibit PLCP activities, the roles of PLCPs in plant-virus interactions and the mechanisms through which viruses neutralize PLCP activities remain largely uncharted. Here, we demonstrate that the...
Lenz, Benjamin Ehrens, Alexandra Ajendra, Jesuthas Risch, Frederic Gal, Joséphine Neumann, Anna-Lena Reichwald, Julia J Strutz, Wiebke McSorley, Henry J Martin, Coralie
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Published in
PLoS pathogens
Eosinophilia is a hallmark of helminth infections and eosinophils are essential in the protective immune responses against helminths. Nevertheless, the distinct role of eosinophils during parasitic filarial infection, allergy and autoimmune disease-driven pathology is still not sufficiently understood. In this study, we established a mouse model fo...
Kang, Yuanrong Lin, Wenwu Nagy, Peter D
Published in
PLoS pathogens
Elaborate viral replication organelles (VROs) are formed to support positive-strand RNA virus replication in infected cells. VRO formation requires subversion of intracellular membranes by viral replication proteins. Here, we showed that the key ATG8f autophagy protein and NBR1 selective autophagy receptor were co-opted by Tomato bushy stunt virus ...
Kurtz, Sherry L Baker, Richard E Boehm, Frederick J Lehman, Chelsea C Mittereder, Lara R Khan, Hamda Rossi, Amy P Gatti, Daniel M Beamer, Gillian Sassetti, Christopher M
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Published in
PLoS pathogens
Mycobacterium tuberculosis (M.tb.) infection leads to over 1.5 million deaths annually, despite widespread vaccination with BCG at birth. Causes for the ongoing tuberculosis endemic are complex and include the failure of BCG to protect many against progressive pulmonary disease. Host genetics is one of the known factors implicated in susceptibility...
Shannon, Blake A Hurst, Jacklyn R Flannagan, Ronald S Craig, Heather C Rishi, Aanchal Kasper, Katherine J Tuffs, Stephen W Heinrichs, David E McCormick, John K
Published in
PLoS pathogens
Streptococcus pyogenes is a human-specific pathogen that commonly colonizes the upper respiratory tract and skin, causing a wide variety of diseases ranging from pharyngitis to necrotizing fasciitis and toxic shock syndrome. S. pyogenes has a repertoire of secreted virulence factors that promote infection and evasion of the host immune system inclu...
Matsuda, Mami Hirai-Yuki, Asuka Kotani, Osamu Kataoka, Michiyo Zheng, Xin Yamane, Daisuke Yokoyama, Masaru Ishii, Koji Muramatsu, Masamichi Suzuki, Ryosuke
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Published in
PLoS pathogens
No antiviral drugs currently are available for treatment of infection by hepatitis A virus (HAV), a causative agent of acute hepatitis, a potentially life-threatening disease. Chemical screening of a small-compound library using nanoluciferase-expressing HAV identified loxapine succinate, a selective dopamine receptor D2 antagonist, as a potent inh...
Ware, Brian C Parks, M Guston da Silva, Mariana O L Morrison, Thomas E
Published in
PLoS pathogens
Infection by chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes severe polyarthralgia and polymyalgia, which can last in some people for months to years. Chronic CHIKV disease signs and symptoms are associated with the persistence of viral nucleic acid and antigen in tissues. Like humans and nonhuman primates, CHIKV infection in mice re...
Ringe, Rajesh P Colin, Philippe Ozorowski, Gabriel Allen, Joel D Yasmeen, Anila Seabright, Gemma E Lee, Jeong Hyun Antanasijevic, Aleksandar Rantalainen, Kimmo Ketas, Thomas
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Published in
PLoS pathogens
Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction of infectivity at maximum neutralization, which may also influence preventive efficacy of active or passive immunization and the th...
Zmarlak, Natalia Marta Lavazec, Catherine Brito-Fravallo, Emma Genève, Corinne Aliprandini, Eduardo Aguirre-Botero, Manuela Camille Vernick, Kenneth D Mitri, Christian
Published in
PLoS pathogens
Leucine-rich repeat (LRR) proteins are commonly involved in innate immunity of animals and plants, including for pattern recognition of pathogen-derived elicitors. The Anopheles secreted LRR proteins APL1C and LRIM1 are required for malaria ookinete killing in conjunction with the complement-like TEP1 protein. However, the mechanism of parasite imm...
