Dynesen, Lasse Toftdal Fernandez, Ignacio Coquin, Youna Delaplace, Manon Montange, Thomas Njouom, Richard Bilounga-Ndongo, Chanceline Rey, Félix A Gessain, Antoine Backovic, Marija
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Published in
PLoS pathogens
Infection with viruses of animal origin pose a significant threat to human populations. Simian foamy viruses (SFVs) are frequently transmitted to humans, in which they establish a life-long infection, with the persistence of replication-competent virus. However, zoonotic SFVs do not induce severe disease nor are they transmitted between humans. Thu...
Lin, Qiqi Huang, Jiahui Liu, Zhiqing Chen, Qunyi Wang, Xinbo Yu, Guohui Cheng, Ping Zhang, Lian-Hui Xu, Zeling
Published in
PLoS pathogens
Pseudomonas aeruginosa, a major inhabitant of numerous environmental reservoirs, is a momentous opportunistic human pathogen associated with severe infections even death in the patients suffering from immune deficiencies or metabolic diseases. Type III secretion system (T3SS) employed by P. aeruginosa to inject effector proteins into host cells is ...
Gomes, Fabio M Silva, Melissa Molina-Cruz, Alvaro Barillas-Mury, Carolina
Published in
PLoS pathogens
Butterworth, Simon Torelli, Francesca Lockyer, Eloise J Wagener, Jeanette Song, Ok-Ryul Broncel, Malgorzata Russell, Matt R G Moreira-Souza, Aline Cristina A Young, Joanna C Treeck, Moritz
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Published in
PLoS pathogens
Toxoplasma gondii is an intracellular parasite that can infect many host species and is a cause of significant human morbidity worldwide. T. gondii secretes a diverse array of effector proteins into the host cell which are critical for infection. The vast majority of these secreted proteins have no predicted functional domains and remain uncharacte...
Nevers, Quentin Scrima, Nathalie Glon, Damien Le Bars, Romain Decombe, Alice Garnier, Nathalie Ouldali, Malika Lagaudrière-Gesbert, Cécile Blondel, Danielle Albertini, Aurélie
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Published in
PLoS pathogens
Rabies virus (RABV) transcription and replication take place within viral factories having liquid properties, called Negri bodies (NBs), that are formed by liquid-liquid phase separation (LLPS). The co-expression of RABV nucleoprotein (N) and phosphoprotein (P) in mammalian cells is sufficient to induce the formation of cytoplasmic biocondensates h...
Liu, Yaqing Katoh, Hiroshi Sekizuka, Tsuyoshi Bae, Chaewon Wakata, Aika Kato, Fumihiro Sakata, Masafumi Yamaji, Toshiyuki Wang, Zhiyu Takeda, Makoto
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Published in
PLoS pathogens
Mumps virus (MuV) is the etiological agent of mumps, a disease characterized by painful swelling of the parotid glands and often accompanied by severe complications. To understand the molecular mechanism of MuV infection, a functional analysis of the involved host factors is required. However, little is known about the host factors involved in MuV ...
Sadasivan, Jibin Vlok, Marli Wang, Xinying Nayak, Arabinda Andino, Raul Jan, Eric
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PLoS pathogens
Viruses have evolved mechanisms to modulate cellular pathways to facilitate infection. One such pathway is the formation of stress granules (SG), which are ribonucleoprotein complexes that assemble during translation inhibition following cellular stress. Inhibition of SG assembly has been observed under numerous virus infections across species, sug...
Lee, Ju Hyun Kwon, Mookwang Lim, Woo Young Yoo, Chae Rin Yoon, Youngik Han, Dasol Ahn, Jin-Hyun Yoon, Keejung
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PLoS pathogens
YES-associated protein (YAP), a critical actor of the mammalian Hippo signaling pathway involved in diverse biological events, has gained increased recognition as a cellular factor regulated by viral infections, but very few studies have investigated their relationship vice versa. In this study, we show that YAP impairs HCMV replication as assessed...
Boon, Adrianus C M Darling, Tamarand L Halfmann, Peter J Franks, John Webby, Richard J Barouch, Dan H Port, Julia R Munster, Vincent J Diamond, Michael S Kawaoka, Yoshihiro
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Published in
PLoS pathogens
Yin, Chao Gu, Jiaojie Gu, Dan Wang, Zhenyu Ji, Ruoyun Jiao, Xinan Li, Qiuchun
Published in
PLoS pathogens
Invasion plasmid antigen J (IpaJ) is a protein with cysteine protease activity that is present in Salmonella and Shigella species. Salmonella enterica serovar Pullorum uses IpaJ to inhibit the NF-κB pathway and the subsequent inflammatory response, resulting in bacterial survival in host macrophages. In the present study, we performed a DNA pull-do...
