Correction: Single-cell in vivo imaging of cellular circadian oscillators in zebrafish.
Published in PLoS biology
[This corrects the article DOI: 10.1371/journal.pbio.3000435.].
Strategic testing approaches for targeted disease monitoring can be used to inform pandemic decision-making.
...Published in PLoS biology
More than 1.6 million Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) tests were administered daily in the United States at the peak of the epidemic, with a significant focus on individual treatment. Here, we show that objective-driven, strategic sampling designs and analyses can maximize information gain at the population level, which...
Comprehensive glycoproteomics shines new light on the complexity and extent of glycosylation in archaea.
Published in PLoS biology
Glycosylation is one of the most complex posttranslational protein modifications. Its importance has been established not only for eukaryotes but also for a variety of prokaryotic cellular processes, such as biofilm formation, motility, and mating. However, comprehensive glycoproteomic analyses are largely missing in prokaryotes. Here, we extend th...
Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprog...
...Published in PLoS biology
Hypoxia drives aging and promotes age-related cognition and hearing functional decline. Despite the role of erythrocytes in oxygen (O2) transport, their role in the onset of aging and age-related cognitive decline and hearing loss (HL) remains undetermined. Recent studies revealed that signaling through the erythrocyte adenosine A2B receptor (ADORA...
Response thresholds alone cannot explain empirical patterns of division of labor in social insects.
Published in PLoS biology
The effects of heterogeneity in group composition remain a major hurdle to our understanding of collective behavior across disciplines. In social insects, division of labor (DOL) is an emergent, colony-level trait thought to depend on colony composition. Theoretically, behavioral response threshold models have most commonly been employed to investi...
Rapid microstructural plasticity in the cortical semantic network following a short language learning session.
Published in PLoS biology
Despite the clear importance of language in our life, our vital ability to quickly and effectively learn new words and meanings is neurobiologically poorly understood. Conventional knowledge maintains that language learning-especially in adulthood-is slow and laborious. Furthermore, its structural basis remains unclear. Even though behavioural mani...
Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the pr...
...Published in PLoS biology
The heart develops from 2 sources of mesoderm progenitors, the first and second heart field (FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage tracing and live imaging, we find the FHF and SHF are subdivided into distinct pools of progenitors in gastrulating mouse embryos at earlier stages than previously thought....
Neural oscillations are a start toward understanding brain activity rather than the end.
Published in PLoS biology
Does rhythmic neural activity merely echo the rhythmic features of the environment, or does it reflect a fundamental computational mechanism of the brain? This debate has generated a series of clever experimental studies attempting to find an answer. Here, we argue that the field has been obstructed by predictions of oscillators that are based more...
The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures.
...Published in PLoS biology
Although visceral adipocytes located within the body's central core are maintained at approximately 37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell and generally exist at cooler temperatures. Responses of brown and beige/brite adipocytes to cold stress are well studied; however, c...
Glyphosate inhibits melanization and increases susceptibility to infection in insects.
Published in PLoS biology
Melanin, a black-brown pigment found throughout all kingdoms of life, has diverse biological functions including UV protection, thermoregulation, oxidant scavenging, arthropod immunity, and microbial virulence. Given melanin's broad roles in the biosphere, particularly in insect immune defenses, it is important to understand how exposure to ubiquit...
