Leitão, Joana Meuleman, Ben Van De Ville, Dimitri Vuilleumier, Patrik
Published in
PLoS biology
Emotions are multifaceted phenomena affecting mind, body, and behavior. Previous studies sought to link particular emotion categories (e.g., fear) or dimensions (e.g., valence) to specific brain substrates but generally found distributed and overlapping activation patterns across various emotions. In contrast, distributed patterns accord with multi...
Kessissoglou, Irini A Langui, Dominique Hasan, Amr Maral, Maral Dutta, Suchetana B Hiesinger, Peter Robin Hassan, Bassem A
Published in
PLoS biology
The amyloid precursor protein (APP) is a structurally and functionally conserved transmembrane protein whose physiological role in adult brain function and health is still unclear. Because mutations in APP cause familial Alzheimer's disease (fAD), most research focuses on this aspect of APP biology. We investigated the physiological function of APP...
Lupperger, Valerio Marr, Carsten Chapouton, Prisca
Published in
PLoS biology
Regulation of quiescence and cell cycle entry is pivotal for the maintenance of stem cell populations. Regulatory mechanisms, however, are poorly understood. In particular, it is unclear how the activity of single stem cells is coordinated within the population or if cells divide in a purely random fashion. We addressed this issue by analyzing divi...
Vasquez-Rifo, Alejandro Ricci, Emiliano P Ambros, Victor
Published in
PLoS biology
Pathogens such as Pseudomonas aeruginosa advantageously modify animal host physiology, for example, by inhibiting host protein synthesis. Translational inhibition of insects and mammalian hosts by P. aeruginosa utilizes the well-known exotoxin A effector. However, for the infection of Caenorhabditis elegans by P. aeruginosa, the precise pathways an...
Zhong, Qiyun Roumeliotis, Theodoros I Kozik, Zuza Cepeda-Molero, Massiel Fernández, Luis Ángel Shenoy, Avinash R Bakal, Chris Frankel, Gad Choudhary, Jyoti S
Published in
PLoS biology
Clustering of the enteropathogenic Escherichia coli (EPEC) type III secretion system (T3SS) effector translocated intimin receptor (Tir) by intimin leads to actin polymerisation and pyroptotic cell death in macrophages. The effect of Tir clustering on the viability of EPEC-infected intestinal epithelial cells (IECs) is unknown. We show that EPEC in...
Najar, Anis Bonnet, Emmanuelle Bahrami, Bahador Palminteri, Stefano
Published in
PLoS biology
While there is no doubt that social signals affect human reinforcement learning, there is still no consensus about how this process is computationally implemented. To address this issue, we compared three psychologically plausible hypotheses about the algorithmic implementation of imitation in reinforcement learning. The first hypothesis, decision ...
Fan, Xiaoying Tang, Dong Liao, Yuhan Li, Pidong Zhang, Yu Wang, Minxia Liang, Fan Wang, Xiao Gao, Yun Wen, Lu
...
Published in
PLoS biology
The development of next generation sequencing (NGS) platform-based single-cell RNA sequencing (scRNA-seq) techniques has tremendously changed biological researches, while there are still many questions that cannot be addressed by them due to their short read lengths. We developed a novel scRNA-seq technology based on third-generation sequencing (TG...
Thomas, Matthew B
Published in
PLoS biology
Bianchi, Enrica Wright, Gavin J
Published in
PLoS biology
Sexual reproduction is such a successful way of creating progeny with subtle genetic variations that the vast majority of eukaryotic species use it. In mammals, it involves the formation of highly specialised cells: the sperm in males and the egg in females, each carrying the genetic inheritance of an individual. The interaction of sperm and egg cu...
Verneuil, Jérémy Brocard, Cécile Trouplin, Virginie Villard, Laurent Peyronnet-Roux, Julie Brocard, Frédéric
Published in
PLoS biology
The central pattern generator (CPG) for locomotion is a set of pacemaker neurons endowed with inherent bursting driven by the persistent sodium current (INaP). How they proceed to regulate the locomotor rhythm remained unknown. Here, in neonatal rodents, we identified a persistent potassium current critical in regulating pacemakers and locomotion s...
