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Multi-site fungicides suppress banana Panama disease, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4

Published in PLoS Pathogens

Bananas are amongst the most popular fruits eaten world-wide, yet their production is seriously challenged by the fungus Fusarium oxysporum f. sp. cubense , Tropical Race 4 (FocTR4). Hitherto, no effective strategy to control this devastating disease has been described. Indeed, even fungicides, which are generally considered to be our "front-line w...

Epstein–Barr virus oncoprotein–driven B cell metabolism remodeling

Published in PLoS Pathogens

Not your Mother's MAPKs: Apicomplexan MAPK function in daughter cell budding.

Published in PLoS pathogens

Reversible phosphorylation by protein kinases is one of the core mechanisms by which biological signals are propagated and processed. Mitogen-activated protein kinases, or MAPKs, are conserved throughout eukaryotes where they regulate cell cycle, development, and stress response. Here, we review advances in our understanding of the function and bio...

An introduction to the Marburg virus vaccine consortium, MARVAC.

Published in PLoS pathogens

The emergence of Marburg virus (MARV) in Guinea and Ghana triggered the assembly of the MARV vaccine "MARVAC" consortium representing leaders in the field of vaccine research and development aiming to facilitate a rapid response to this infectious disease threat. Here, we discuss current progress, challenges, and future directions for MARV vaccines...

Into the wild: How exposure to wild or domesticated fungi shapes immune responses in mice.

Published in PLoS pathogens

Current treatments against mucormycosis and future directions.

Published in PLoS pathogens

Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of fungi belonging to the order Mucorales. These molds exist throughout the environment and generally do not cause serious problems in humans. Mucormycosis mainly affects individuals who are immunocompromised. The clinical manifestations of mucormy...

A toolbox of engineered mosquito lines to study salivary gland biology and malaria transmission.

Published in PLoS pathogens

Mosquito saliva is a vehicle for the transmission of vector borne pathogens such as Plasmodium parasites and different arboviruses. Despite the key role of the salivary glands in the process of disease transmission, knowledge of host-pathogen interactions taking place within this organ is very limited. To improve the experimental tractability of th...

Knockout of signal peptide peptidase in the eye reduces HSV-1 replication and eye disease in ocularly infected mice

Published in PLoS Pathogens

Interaction of HSV-1 gK and signal peptide peptidase (SPP) plays an essential role in HSV-1 infectivity. To evaluate the importance of gK binding to SPP in the eye following primary virus replication and latency-reactivation, we evaluated SPP in the eye using Pax6-SPP-/- conditional knockout mice. The absence of SPP in the eye significantly reduced...

Karyotype variation, spontaneous genome rearrangements affecting chemical insensitivity, and expression level polymorphi...

Published in PLoS Pathogens

Strains of the oomycete Phytophthora infestans from nature vary in traits including aggressiveness and chemical resistance, and range from diploid to tetraploid. What causes such variation in this important potato and tomato pathogen is largely unknown. To study this we generated the species’ first chromosome-scale assembly and employed it to study...

miRNA let-7 family regulated by NEAT1 and ARID3A/NF-κB inhibits PRRSV-2 replication in vitro and in vivo

Published in PLoS Pathogens

There are significant differences in susceptibility/resistance to PRRSV among different pig breeds. Especially the local pig breeds in China had strong resistance to PRRSV. However, due to the complexity of the interaction mechanism between pigs and PRRSV, the genetic mechanism leading to PRRSV susceptibility/resistance in different pig breeds is s...