Das, Subrata Maiti, Sanajit Mukhopadhyay, Balaram
Published in
Organic & biomolecular chemistry
Chemical synthesis of the tetrasaccharide repeating unit of the O-specific polysaccharide from Enterobacter cloacae G3422 is reported. The synthesis of the target tetrasaccharide is achieved through a convergent [2 + 2]-block strategy. The conjugation ready target oligosaccharide is attractive for further glycoconjugate formation with a suitable ag...
Miao, He Lu, Siqian Chen, Hongyu Shang, Jintao Zheng, Jibin Yang, You
Published in
Organic & biomolecular chemistry
A DMF-modulated glycosylation approach for the stereoselective synthesis of α-Kdo glycosides with readily accessible peracetylated Kdo ynenoate as a donor was described. By utilizing this approach, we completed the synthesis of various linkage types of Kdo-Kdo disaccharides and the α-Kdo-containing protected trisaccharide variant relevant to the li...
David, Louis-Philippe Ferron, Solenn Favreau, Bénédicte Yeni, Oznur Ollivier, Simon Ropartz, David Compagnon, Isabelle Ferrières, Vincent Le Dévéhat, Françoise Legentil, Laurent
...
Published in
Organic & biomolecular chemistry
The synthesis of six model trisaccharides representative of galactomannans produced by lichens was performed through stereoselective glycosylation. These standards include linear and branched galactomannans bearing either galactofuranosyl or galactopyranosyl entities. The complete assignment of 1H and 13C signals for both forms of synthetically red...
Decha, Nattawut Thonglam, Jutakan Meesane, Jirut Pornsuwan, Soraya Tansakul, Chittreeya
Published in
Organic & biomolecular chemistry
High content of reactive oxygen species (ROS) in the human body leads to oxidative stress and serious health problems, such as cancer and cardiovascular or bone diseases. It is also one of the agents that cause collagen damage. Herein, detection of ROS, scavenging of formed carbon-centered radicals and inhibition of collagen fragmentation were perf...
Bandyopadhyay, Ayan Biswas, Pranay Kundu, Sudipta K Sarkar, Rajib
Published in
Organic & biomolecular chemistry
Selective chemical reactions at precise amino acid residues of peptides and proteins have become an exploding field of research in the last few decades. With the emerging utility of bioconjugated peptides and proteins as drug leads and therapeutic agents, the design of smart protocols to modulate and conjugate biomolecules has become necessary. Dur...
Chen, Siyi Zhou, Jieyu Gu, Xiangyuan Ni, Ye
Published in
Organic & biomolecular chemistry
Biocatalytic oxidation is one of the most important and indispensable organic reactions for the development of green and sustainable biomanufacturing processes. NAD(P)+-dependent aldehyde dehydrogenase (ALDH) catalyzes the oxidation of aldehydes to carboxylic acids. Here, two ALDHs, SpALDH1 and SpALDH2, were identified from Sphingobium sp. SYK-6. T...
Du, Quan-Rong Peng, Min Tian, Yang Yao, Xue Zheng, Jianfeng Peng, Yu Wang, Ya-Wen
Published in
Organic & biomolecular chemistry
A new fluorescent probe SWJT-23 with lysosomal targeting ability for detection of hypobromous acid (HBrO) was synthesised based on the naphthalimide skeleton. This probe exhibited a fast response (within 3s), a low detection limit (1.24 nM), excellent selectivity and a high fluorescence quantum yield (Φ = 0.490). Moreover, SWJT-23 not only realized...
Hu, Haoran Liu, Yu Li, Junqi Zhang, Chong Gao, Chao Sun, Chengguo Du, Yang Hu, Bingcheng
Published in
Organic & biomolecular chemistry
Functionalization is a major challenge for the application of photoswitches. With the aim to develop novel bis-functional azo photoswitches with stationary photophysical properties, a series of phenolylazoindole derivatives were designed, synthesized, and characterized via NMR spectroscopy studies and high-resolution mass spectrometry (HRMS). Herei...
Nazeri, Mohammad Taghi Nasiriani, Tahereh Torabi, Saeed Shaabani, Ahmad
Published in
Organic & biomolecular chemistry
Benzopyrans (BZPs) are among the most privileged and influential small O-heterocycles that form the core of many natural compounds, commercial drugs, biological compositions, agrochemicals, and functional materials. BZPs are divided into six general categories including coumarins, chromans, 2H-chromenes, 4H-chromenes, chromones, and 4-chromanones, ...
Hazarika, Roktopol Dutta, Sanghamitra Sarmah, Samprity Hazarika, Priyanuj Krishnann Singh, Kuldeep Kumar, Arvind Sarma, Bipul Sarma, Diganta
Published in
Organic & biomolecular chemistry
An approach towards Cu-free click chemistry has been developed in this work. Silver-catalyzed PCy3-ligand-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles at room temperature has been developed. Regioselectivity of the reaction was confirmed from the results of single-crystal X-ray diffraction (SC-XRD) of one of the products. SC-XRD of ex si...
