Malasala, Satyaveni Polomoni, Anusha Chelli, Sai Manohar Kar, Swayamsidda Madhavi, Y V Nanduri, Srinivas
Published in
Organic & biomolecular chemistry
A method for the microwave-assisted copper-mediated oxidative coupling reaction of different aldehydes and quinazolines/benzimidazoles has been developed for the synthesis of fused-polycyclic systems via new C-N bond formation. The current methodology involves the use of environmentally benign NH4OAc as the amine source in the presence of 2-propano...
Wang, Wei-Ming Yu, Chen-Hsu Chang, Jing-Yuan Chen, Ting-Hsuan Chen, Yan-Chen Sun, Yi-Ting Wang, Szu-Huan Jao, Shu-Chuan Cheng, Richard P
Published in
Organic & biomolecular chemistry
Collagen is a major structural component of the extracellular matrix and connective tissue. The key structural feature of collagen is the collagen triple helix, with a Xaa-Yaa-Gly (glycine) repeating pattern. The most frequently occurring triplet is Pro (proline)-Hyp (hydroxyproline)-Gly. The reversible thermal folding and unfolding of a series of ...
Babu, Sheba Ann A R, Rajalekshmi P R, Nitha Omanakuttan, Vishnu K P, Rahul Varughese, Sunil John, Jubi
Published in
Organic & biomolecular chemistry
We have come across an unexpected reaction between electrophilic indoles and isoquinolinium methylides for accessing functionalized pyrrolo[2,1-a]isoquinolines. The reaction was found in general to yield the products in good yields. We also observed the formation of S-S-bridged bis-pyrrolo[2,1-a]isoquinolines from the reaction of 3-nitro benzothiop...
Tuktarov, Airat R Khuzina, Liliya L Sadretdinova, Zarema R Makarova, Elina Kh Dzhemileva, Lilya U D'yakonov, Vladimir A Dzhemilev, Usein M
Published in
Organic & biomolecular chemistry
Previously unreported macrodiolides containing a 1Z,5Z-diene fragment in the structure have been synthesized with high yields and stereoselectivity by our research group, using the intermolecular esterification of malonic acid with α,ω-diols containing bis-methylene-separated Z-double bonds, catalyzed by Hf(OTf)4 hafnium triflate. Under Bingel-Hirs...
Fu, Jian Fu, Huixiao Xia, Yufen N'Go, Inès Cao, Jun Pan, Weidong Vincent, Stéphane P
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Organic & biomolecular chemistry
An in situ screening assay for UDP-galactopyranose mutase (UGM, an essential enzyme of M. tuberculosis cell wall biosynthesis) has been developed to discover novel UGM inhibitors. The approach is based on the amide-forming reaction of an amino acid core with various cinnamic acids, followed by a direct fluorescence polarization assay to identify th...
Zhang, Yuan Lai, Weiping Zhang, Lianpeng Gao, Xiaoxing Qiu, Guanyinsheng Zhou, Hongwei
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Organic & biomolecular chemistry
In recent years, one of the main research interests of our group has been the construction of 6/5 π-systems through the regioselective conversion of parallel alkynes in naphthalene with the aim of exploiting potential fluorescent materials. Herein, the copper-catalyzed synthesis of polysubstituted (Z)-2H-naphtho[1,8-bc]thiophenes from 8-halo-1-ethy...
Essam, Zahraa M Ozmen, Guliz Ersoy Setiawan, Dani Hamid, Riri Rizkianty Abd El-Aal, Reda M Aneja, Ritu Hamelberg, Donald Henary, Maged
Published in
Organic & biomolecular chemistry
Donor-π-acceptor (D-π-A) fluorophores consisting of a donor unit, a π linker, and an acceptor moiety have attracted attention in the last decade. In this study, we report the synthesis, characterization, optical properties, TD-DFT, and cytotoxicity studies of 17 near infrared (NIR) D-π-A analogs which have not been reported so far to the best of ou...
Menelle, Pauline Quintin, Jérôme Cottet, Kevin Fromentin, Yann Dupont, Joëlle Lallemand, Marie-Christine Buisson, Didier
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Organic & biomolecular chemistry
The search for active microorganisms for the biotransformation of guttiferone A (1) and C (6) has been successfully undertaken from a collection of endophytic fungi of Symphonia globulifera. Of the twenty-five isolates obtained from the leaves, three are active and have been identified as Bipolaris cactivora. The products obtained are the result of...
Ghosh, Arun K Allu, Srinivasa Rao Reddy, Guddeti Chandrashekar Lopez, Adriana Gamboa Mendez, Patricia Jurica, Melissa S
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Organic & biomolecular chemistry
Herboxidiene is a potent antitumor agent that targets the SF3B subunit of the spliceosome. Herboxidiene possesses a complex structural architecture with nine stereocenters and design of potent less complex structures would be of interest as a drug lead as well as a tool for studying SF3B1 function in splicing. We investigated a number of C-6 modifi...
Baruah, Biswajita Deb, Mohit L
Published in
Organic & biomolecular chemistry
This review focuses on the catalyst- and additive-free C-C bond forming reactions reported mostly from the year 2005 to date. C-C bond forming reactions are highly important as large and complex organic molecules can be derived from simpler ones via these reactions. On the other hand, catalyst- and additive-free reactions are economical, environmen...