Long, Xueyuan Yang, Yanpeng Zhou, Ke
Published in
Open Medicine
Background Sepsis triggers myocardial injury and dysfunction, leading to a high mortality rate in patients. Cardiomyocyte apoptosis plays a positive regulatory role in septic myocardial injury and dysfunction. However, the mechanism is unclear. Methods Bioinformatics analysis was used to identify differentially expressed genes in septic mice heart ...
Xu, Weihua Hu, Junjie Ma, Zhichao Feng, Wanyi Gong, Wei Fu, Shengmiao Chen, Xinping
Published in
Open Medicine
Metastasis significantly contributes to the poor prognosis of advanced nasopharyngeal carcinoma (NPC). Our prior studies have demonstrated a decrease in BIRC5-206 expression in NPC, which promotes disease progression. However, the role of BIRC5-206 in the invasion and metastasis of NPC has not been fully elucidated. In this study, our objective was...
Yin, Qinghua Guo, Na Fu, Ping Zhong, Hui
Published in
Open Medicine
Objective The aim of this study was to investigate iron status and iron deficiency in incident continuous ambulatory peritoneal dialysis (CAPD) patients and identify influencing factors. Methods Patients with end-stage renal disease were enrolled. Clinical data of iron metabolism and biochemical and dialysis parameters during the first peritoneal d...
Lv, Panpan Cao, Zhen Zhu, Zhengqi Xu, Xiaoqin Zhao, Zhen
Published in
Open Medicine
Background The efficacy of artificial neural network (ANN) models employing laboratory variables for predicting fatty liver disease (FLD) remains inadequately established. The study aimed to develop ANN models to precisely predict FLD. Methods Of 12,058 participants undergoing the initial FLD screening, 7,990 eligible participants were included. A ...
Yuan, Haichuan Huang, Min Liu, Tao Song, Wu Luo, Chengpeng
Published in
Open Medicine
Objective To investigate the effect of three-dimensional (3D) reconstruction-assisted cognitive fusion in targeted prostate biopsy. Results There was no significant difference in the detection rate of prostate cancer (PCa) between targeted biopsy and systematic biopsy, and there was significant difference in the detection rate of clinically signifi...
Long, Yan Ge, Xiaodong Ma, Liangliang Guo, Junhua Zhu, Yong
Published in
Open Medicine
This study aimed to elucidate the effects and potential mechanisms of dioscin on chronic prostatitis (CP) in vivo and in vitro. CP models were constructed in vivo and in vitro and treated with different concentrations of dioscin. Hematoxylin and eosin staining was used to investigate the morphology of the prostate tissues. The concentration of infl...
Yu, Shasha Huang, Lujie Ren, Jianfei Zhang, Xiaoying
Published in
Open Medicine
Background Sporadic thoracic aortic aneurysm and dissection (sTAAD) is a complicated vascular disease with a high mortality rate. And its genetic basis has not been fully explored. Method Here, 122 sTAAD patients and 98 healthy individuals were recruited, and 10 single nucleotide polymorphisms were selected and analyzed (FBN1 rs10519177, rs1036477,...
Liu, Tao Zheng, Fenshuang Liu, Lin Zhou, Hua Shen, Tao Li, Yanping Zhang, Wei
Published in
Open Medicine
Background Paraquat (PQ) is a frequently used herbicide with neurotoxic effects after acute or chronic exposure. Although in vitro evidence supports the PQ toxicity to dopamine cells, its in vivo effects (especially the chronic exposure) remain ambiguous. In this study, we investigated the effect of chronic PQ exposure on the blood–brain barrier (B...
Liu, Min Ma, Jianning Bao, Kena Gu, Ye Zhao, Jing Ren, Dongmei Zhu, Fang Xu, Xiangdong
Published in
Open Medicine
Background The pathogenesis of cognitive impairment (CI) in coronary artery disease (CAD) patients is still unclear and numerous influence factors could affect the CI status. The current studies suggest that sleep quality and behavior pattern are significant influence factors associated with CAD susceptibility. Methods A total of 223 participants i...
Xu, Yi Fei, Xiangyong
Published in
Open Medicine
Objective To explore the relationship between cytokines such as interferon γ (IFN-γ), interleukin-10 (IL-10), and interleukin-6 (IL-6), as well as the severity of the condition, and serum zinc (Zn) and Fe levels in children with Mycoplasma pneumoniae infection. Methods A simple random sampling method was used to select 108 children with Mycoplasma ...
