Behairy, Sabreen Mohammed Al-Maaqar, Saleh Mohammed Al-Shaeri, Majed Ahmed
Published in
Open Life Sciences
Breast cancer (BC) has a prevalence rate of 21.8% among Saudi women and ranks as the third leading cause of death in Western nations. Nanotechnology offers innovative methods for targeted BC therapy, and this study explores the use of single-walled carbon nanotubes (SWCNTs) for delivering the senna leaf extract. The study evaluated the effects of i...
Breuer, Helen Bell-Simons, Michael Zempel, Hans
Published in
Open Life Sciences
Cell polarity is crucial in neurons, characterized by distinct axonal and dendritic structures. Neurons generally have one long axon and multiple shorter dendrites, marked by specific microtubule (MT)-associated proteins, e.g., MAP2 for dendrites and TAU for axons, while the scaffolding proteins AnkG and TRIM46 mark the axon-initial-segment. In tau...
Li, JianFang Zhang, PengFei Zeng, XianJing Liu, Rong
Published in
Open Life Sciences
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability worldwide, and circRNA dysregulation is functionally associated with COPD. This study explored the potential of circRMRP and circRPL27 as biomarkers of COPD. Blood samples from COPD patients and healthy controls were collected. COPD patients were divid...
Wu, Yanxia Jiang, Wanxiang Wang, Junlong Xie, Guoqing Sun, Yan Yang, Jinliang
Published in
Open Life Sciences
In this study, we integrated transcriptomic and metabolomic analyses to achieve a comprehensive understanding of the underlying mechanisms of diabetic cardiomyopathy (DCM) in a diabetic rat model. Functional and molecular characterizations revealed significant cardiac injury, dysfunction, and ventricular remodeling in DCM. A thorough analysis of gl...
Xia, Liwei Sun, Yongming Zhou, Yue Yang, Qian Huang, Jianhan Liu, Dong
Published in
Open Life Sciences
This study sought to explore the value of major ozonated autohemotherapy (MOA) as a treatment for spinal cord injury (SCI) in a rat model system. In total, 54 female Sprague-Dawley rats were randomized into sham-operated, SCI model, and MOA treatment groups. We found that relative to the SCI model group, rats that underwent MOA treatment exhibited ...
Liang, Guanying Qi, Zijuan Du, Chun
Published in
Open Life Sciences
To investigate the biological role of MFAP5 in endometrial cancer (EC). HEC-1-A and Ishikawa cells overexpressing MFAP5 were created. Cell proliferation, apoptosis, migration, and invasion were evaluated using CCK8, colony formation, flow cytometry, and transwell assays. A western blot was used to analyze the expression of markers affiliated with t...
He, Qian Cai, Yanzhi Kong, Meihua
Published in
Open Life Sciences
Otitis media (OM) is a prevalent childhood ear disease characterized by inflammation of the middle ear cavity, which can lead to ear pain, fever, and hearing loss. The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses, and the function of middle ear epithelial cells....
Mori, Tommaso Nagaraj, Nareshkumar Ragavachetty Surico, Pier Luigi Zhou, Wenjing Parmar, Uday Pratap Singh D’Esposito, Fabiana Gagliano, Caterina Musa, Mutali Zeppieri, Marco
Published in
Open Life Sciences
Retinal diseases, which can lead to significant vision loss, are complex conditions involving various cellular and molecular mechanisms. The interleukin-6 (IL-6) family, particularly Oncostatin M (OSM), has garnered attention for their roles in retinal inflammation, angiogenesis, and neuroprotection. This comprehensive review explores the dual natu...
Song, Liya Li, Lihua
Published in
Open Life Sciences
This study investigated the effects of activation and inhibition of the PI3K/AKT and TLR-4/NF-κB signaling pathways on insulin resistance in a high-fat diet-induced obese rat model. The results indicate that a high-fat diet can activate these signaling pathways by regulating the expression of related proteins, affecting metabolic health. Rat PI3K/A...
Liang, Xiao Zhang, Jie Luo, Ya
Published in
Open Life Sciences
We investigated the protective effect of the NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC) on cardiomyocyte injury induced by HCN1 channel overexpression, and explored the underlying mechanisms. An HCN1 overexpression vector was constructed and transfected into H9C2 cells, followed by PDTC treatment. The experiments comprised the following gr...
