Santos, Jéssica Reis Waitzberg, Dan Linetzky da Silva, Ismael Dale Cotrim Guerreiro Junior, Tharcisio Citrangulo Tortelli Barros, Luciana Rodrigues Carvalho Canuto, Gisele André Baptista Faccio, Andréa Tedesco Yamaguchi, Lydia Fumiko Kato, Massuo Jorge Tavares, Marina Franco Maggi
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Published in
Oncotarget
Altered cell metabolism is a hallmark of cancer and critical for its development. Particularly, activation of one-carbon metabolism in tumor cells can sustain oncogenesis while contributing to epigenetic changes and metabolic adaptation during tumor progression. We assessed whether increased one-carbon metabolism activity is a metabolic feature of ...
Kinahan, Cristina Mangone, Michael A. Scotto, Luigi Visentin, Michele Marchi, Enrica Cho, Hearn Jay O’Connor, Owen A.
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Oncotarget
Multiple myeloma (MM) is the second most common hematologic malignancy. While major advances have been made in the disease, it is still incurable. Although antifolate-based drugs are not commonly used to treat myeloma, new generation analogs with distinct patterns of preclinical and clinical activity may offer an opportunity to identify new classes...
Liu, Yuexin
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Oncotarget
Assay for transposase-accessible chromatin using sequencing (ATAC-seq) has not yet been widely used in cancer research. Clinical implications of chromatin accessibility assessed by ATAC-seq profiling in human cancers especially in a large patient cohort is largely unknown. In this study, we analyzed ATAC-seq data in 404 cancer patients from the Can...
Kobayashi, Masaki Ishizaki, Yuka Owaki, Mika Matsumoto, Yoko Kakiyama, Yuri Hoshino, Shunsuke Tagawa, Ryoma Sudo, Yuka Okita, Naoyuki Akimoto, Kazunori
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Oncotarget
Poly (ADP-ribose) polymerase 1 (PARP1) plays important roles in single strand DNA repair. PARP1 inhibitors enhance the effects of DNA damaging drugs in homologous recombination-deficient tumors including tumors with breast cancer susceptibility gene (BRCA1) mutation. Nutlin-3a, an analog of cis-imidazoline, inhibits degradation of murine double min...
Yang, Guiqi Ou, Minglin Chen, Huaizhou Guo, Changchun Chen, Jiejing Lin, Hua Tang, Donge Xue, Wen Li, Wenlong Sui, Weiguo
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Oncotarget
Simplicio-Revoredo, Camila Maria de Oliveira Pereira, Renato de Almeida Melo, Mariella Lopes-Costa, Pedro Vitor de Tarso Moura-Borges, Paulo Sousa, Emerson Brandão Neto, Fidelis Manes Campelo, Viriato Soares-Lopes, Ione Maria Ribeiro da Conceição Barros-Oliveira, Maria
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Oncotarget
Background: Cancer and fibroadenoma are the most common breast tumors in women of reproductive age. Nuclear factor erythroid 2-related factor 2 (Nrf2) and the nuclear factor kappaB (NF-κB) transcription factor play an important role in the inflammatory process and in cell proliferation. However, few studies have analyzed these markers in breast can...
Dao, Tu Gapihan, Guillaume Leboeuf, Christophe Hamdan, Diaddin Feugeas, Jean-Paul Boudabous, Hanene Zelek, Laurent Miquel, Catherine Tran, Thuan Monnot, Catherine
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Oncotarget
Background: Brain metastases challenge daily clinical practice, and the mechanisms by which cancer cells cross the blood-brain barrier remain largely undeciphered. Angiopoietin-like 4 (ANGPTL4) proteolytic fragments have controversial biological effects on endothelium permeability. Here, we studied the link between ANGPTL4 and the risk of brain met...
Kumar, Makhan Martin, Ansie Nirgude, Snehal Chaudhary, Bibha Mondal, Sukanta Sarkar, Angshuman
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Oncotarget
Background: Quinacrine (QC) is popular for its anti-malarial activity. It has been reported exhibiting anti-cancerous properties by suppressing nuclear factor-κB and activating p53 signaling; however, its effect on cellular pathways in human non-small cell lung cancer (NSCLC) has not been studied. Materials and Methods: Binding of QC with GSTA1 was...
Karabajakian, Andy Garrivier, Thibaut Crozes, Carole Gadot, Nicolas Blay, Jean-Yves Bérard, Frédéric Céruse, Philippe Zrounba, Philippe Saintigny, Pierre Mastier, Charles
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Oncotarget
Background: Hyperprogressive disease (HPD) rate in head and neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint inhibitors (ICI) was determined using tumor growth kinetics (TGK) and compared with rapidly progressive screen-failure (SF) patients. The impact of TGK on outcomes with salvage chemotherapy (SCT) was also evaluate...
Litchfield, Lacey M. Boehnke, Karsten Brahmachary, Manisha Mur, Cecilia Bi, Chen Stephens, Jennifer R. Sauder, J. Michael Gutiérrez, Sonia M. McNulty, Ann M. Ye, Xiang S.
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Published in
Oncotarget
Aberrant activation of mitogenic signaling pathways in cancer promotes growth and proliferation of cells by activating mTOR and S6 phosphorylation, and D-cyclin kinases and Rb phosphorylation, respectively. Correspondingly, inhibition of phosphorylation of both Rb and S6 is required for robust anti-tumor efficacy of drugs that inhibit cell signalin...
