Parks, Ruth M. Holmes, Holly M. Cheung, Kwok-Leung
Published in
Oncology and Therapy
The number of older adults living with cancer is increasing. There is a clear lack of representation of older adults in clinical trials, including cancer trials. Reasons for this are multifactorial and complex and include protocol, patient and sponsor factors. Potential solutions to overcome issues with trial design include varied methods of recrui...
Gress, Kyle L Charipova, Karina Kaye, Alan D Viswanath, Omar Urits, Ivan
Published in
Oncology and therapy
It is estimated that one-third of oncologic patients in the USA do not receive analgesia proportional to or adequate for the intensity of their pain. A mechanism-based approach to oncologic pain therapy is critical to ensure that analgesia regimens are individualized and effective. Since the mechanisms that lead to cancer pain are complex, healthca...
Watson, Crystal Barlev, Arie Cole, Jason C. Trivedi, Bhumi
Published in
Oncology and Therapy
Introduction There are no validated patient-reported outcome (PRO) instruments for Epstein–Barr virus-driven post-transplant lymphoproliferative disease (EBV+ PTLD). The aim of this study was to assess the content applicability for three frequently used PRO instruments from the perspective of patients with EBV+ PTLD. Methods A moderated focus group...
Collier, Tony Smith, Shievon Greenwood, Michelle Ng, Kenrick
Published in
Oncology and Therapy
This article is co-authored by a patient with metastatic hormone-sensitive prostate cancer who is receiving abiraterone and androgen deprivation therapy treatment in Manchester, UK. The patient relates his personal experiences struggling with the diagnosis, his experience with treatment and the physical, emotional and psychosexual impact on his lif...
Marushchak, Olga Hazan, Ezra Kriegel, David A.
Published in
Oncology and Therapy
The incidence of cutaneous melanoma continues to rise dramatically worldwide, presenting a significant burden to the healthcare system. Despite this, there is still controversy in the guidelines regarding follow-up surveillance for patients with thin melanoma. Since there are no randomized clinical trials to support evidence-based guidelines for fo...
Moreira, Ana C Portela, João Couto, Carlos Duarte, José Martins, Natália Soares, Jorge
Published in
Oncology and therapy
Oxaliplatin-based chemotherapy has been widely used to treat colorectal cancer. Here, we report a case of a 71-year-old man, former smoker (40 pack-years), with no history of relevant exposures such as occupational, environmental or drug exposure. The patient developed acute partial respiratory insufficiency concomitant with the eighth cycle of adj...
Wender, Isabella O. Haines, Kayla Jahanzeb, Mohammad
Published in
Oncology and Therapy
Metastatic breast cancer (BC) is considered incurable, and it is generally treated with sequential single-agent therapies to control it with palliative intent. Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are used in the front-line setting of hormone receptor (HR)-positive, HER2-negative BC, and guidelines discourage the use of a second-line CD...
Taljaard, Melissa Lovric, Germaine T. Makenzi, Aviwe M. Kawinga, Prudence
Published in
Oncology and Therapy
Introduction Prostate cancer is the leading cancer type in black South African men. The South African public healthcare sector serves more than 84% of the population, which includes many of these men. Previous evidence suggests that patients’ information needs are influenced by culture. No studies could be found that explored the information needs ...
de Las Heras, Begoña Saini, Kamal S Boyle, Frances Ades, Felipe de Azambuja, Evandro Bozovic-Spasojevic, Ivana Romano, Marco Capelan, Marta Prasad, Rajeev Pattu, Pugazhenthi
...
Published in
Oncology and therapy
The coronavirus disease-2019 (COVID-19) pandemic has had a significant impact on patients with underlying malignancy. In this article, we summarize emerging data related to patients with cancer and COVID-19. Among patients with COVID-19, a higher proportion have an underlying diagnosis of cancer than seen in the general population. Also, patients w...
Gordon-Craig, Sophie Parks, Ruth M. Cheung, Kwok-Leung
Published in
Oncology and Therapy
A move is under way towards personalised cancer treatment, where tumour biology of an individual patient is examined to give unique predictive and prognostic information. This is extremely important in the setting of older women, who have treatment-specific goals which may differ from their younger counterparts, and may include conservation of qual...
