Li, Xiuqing Zhang, Ji Wu, Youshan Ma, Chuntao Wei, Dongying Pan, Lijuan Cai, Liangliang
Published in
Oncology letters
Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer, and its development, growth, and invasiveness are regulated by the tumor microenvironment (TME). Insulin-like growth factor-binding protein-7 (IGFBP7), which is closely related to various tumors, transforming growth factor-β1 (TGFβ1), which is a key signal media...
Zhang, Xiaoyi Wu, Mian Peng, Gongling Li, Wenhuan Guo, Zhe Li, Hai Jiang, Ming
Published in
Oncology letters
Kinesin family member 2A (KIF2A) has been reported as an oncogene and potential biomarker for the progression of numerous cancer types; however, its role in papillary thyroid carcinoma (PTC) has remained elusive. The present study aimed to assess KIF2A expression in patients with PTC and explore the potential association between KIF2A, clinicopatho...
Ojo, Ademola S Asemota, Joseph Ojukwu, Somtochukwu Rajeh, Ahmad Bot, Amina Smith, Caitlyn J Laziuk, Katsiaryna Saleh, Mohammed
Published in
Oncology letters
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by an exaggerated but dysregulated immune response resulting in hyperinflammation, with a potential for progression to multiple organ dysfunction and failure. Infectious diseases, inflammatory disorders, malignancies and immunodeficiency syndromes are known trigg...
Wang, Zhan Zhang, Mingxin Seery, Samuel Zheng, Guoyang Wang, Wenda Zhao, Yang Wang, Xu Zhang, Yushi
Published in
Oncology letters
N6-methyladenosine (m6A) is the most common type of RNA methylation and is considered to participate in various biological and pathological processes, specifically in the regulation of tumorigenesis and metastasis. However, the exact prognostic role of m6A methylation regulators in early-stage clear cell renal cell carcinoma (ccRCC) is currently un...
Peng, Jinghui Pei, Shengbin Cui, Yangyang Xia, Yiqin Huang, Yue Wu, Xiaowei Zheng, Mingjie Weng, Miaomiao Han, Xu Fu, Hongtao
...
Published in
Oncology letters
In patients with triple-negative breast cancer (TNBC), high tumour mutation burden and aberrant oncogene expression profiles are some of the causes of poor prognosis. Therefore, it is necessary to identify aberrantly expressed oncogenes, since they have the potential to serve as therapeutic targets. Transient receptor potential channel 5 opposite s...
Jiang, Lingyu Liu, Shuyan Deng, Tingzhi Yang, Yang Zhang, Yin
Published in
Oncology letters
Glycogen phosphorylase (GP) is an essential enzyme for glycolysis via the glycogen degradation pathway. It consists of three isoforms: PYGB (brain form), PYGL (liver form) and PYGM (muscle form). Although the abnormal expression of GP is associated with a variety of tumors, its relationship with hepatocellular carcinoma (HCC) and whether it can be ...
Teshima, Taro Kobayashi, Yukari Kawai, Taketo Kushihara, Yoshihiro Nagaoka, Koji Miyakawa, Jimpei Akiyama, Yoshiyuki Yamada, Yuta Sato, Yusuke Yamada, Daisuke
...
Published in
Oncology letters
Immune checkpoint inhibitors have been approved as second-line therapy for patients with advanced urothelial carcinoma (UC). However, which patients will obtain clinical benefit remains to be determined. To identify predictive biomarkers for the pembrolizumab (PEM) response early during treatment, the present study investigated 31 patients with che...
Sun, Zhonghui Guo, Yunyi Zhang, Danlu Zhang, Guolong Zhang, Ying Wang, Xiuli
Published in
Oncology letters
Cutaneous squamous cell carcinoma (CSCC) is one of the most common non-melanoma skin cancers worldwide. Fatty acid-binding protein 7 (FABP7) has been reported to be involved in the occurrence, development, metastasis and prognosis of various tumors. In addition, downregulated FABP7 expression was demonstrated in cutaneous malignant melanoma in a pr...
Wu, Cailiang Zhou, Xuexin Li, Jiayong Xiao, Ruiying Xin, Haomin Dai, Lei Zhu, Yaping Bao, Wei
Published in
Oncology letters
The lymph node status is one of the most critical prognostic factors used in determining adjuvant treatment in endometrial cancer (EC). Lymphadenectomy is associated significant surgical and postoperative risks. The use of sentinel lymph node mapping (SLNM) has emerged as an alternative method to complete lymphadenectomy in EC. However, there remai...
Liu, Qi Lin, Feng
Published in
Oncology letters
Isoleucyl-tRNA synthetase 2 (IARS2), distributed in mitochondria, is an IARS involved in protein synthesis. Notably, IARS2 has been reported to be associated with tumor progression; however, the relationship between osteosarcoma (OS) and IARS2 remains unclear. To investigate the role of IARS2 in human OS, the expression and relationship of IARS2 wi...
