Chuang, Hui-Yen Tyan, Yeu-Sheng Hwang, Jeng-Jong Shih, Kuang-Chung Lin, Wei-Chan
Published in
Oncology Letters
Hepatocellular carcinoma (HCC) is difficult to diagnose at an early stage, and its prognosis is generally poor. Sorafenib is the primary treatment for unresectable advanced HCC and targets multiple receptor tyrosine kinases. However, sorafenib only extends the average survival time by 3 months. This observation indicates that sorafenib may need to ...
Harrison, Bridget Marie Loukopoulos, Panayiotis
Published in
Oncology Letters
The sequencing of the canine genome, combined with additional genomic technologies, has created opportunities for research linking veterinary genomics with naturally occurring cancer in dogs. Also, as numerous canine cancers have features in common with human cancers, comparative studies can be performed to evaluate the use of cancers in dogs as mo...
Ni, Kun Zhang, Wei Ni, Yuan Mao, Yan-Ting Wang, Yi Gu, Xiao-Ping Ma, Zheng-Liang
Published in
Oncology Letters
Mechanical allodynia is a painful perception of mechanical stimuli and one of the typical symptoms in bone cancer pain (BCP). Previous studies have revealed that mice and humans lacking mechanically activated Piezo2 channels do not sense mechanical stimuli. However, the underlying mechanism of Piezo2 in BCP has not been well established. The aim of...
Tran, Cuong Minh Kuroshima, Takeshi Oikawa, Yu Michi, Yasuyuki Kayamori, Kou Harada, Hiroyuki
Published in
Oncology Letters
Pigmented oral squamous cell carcinoma (POSCC) is a rare and underrecognized pathological variant of oral squamous cell carcinoma (OSCC). The current study aimed to evaluate the clinicopathological characteristics, treatment outcomes and prognosis of patients with POSCC and to investigate its oncological properties using immunohistochemical studies...
Zhang, Yuhan Gu, Xinquan Jiang, Fuquan Sun, Pinghui Li, Xu
Published in
Oncology Letters
Striatin-4 (STRN4 or Zinedin) is a scaffolding protein belonging to the mammalian STRN family of proteins and consists of multiple functional signaling domains. Due to its numerous signaling complexes, STRN4 has been reported to be involved in the tumorigenesis of various cancer types, including colon cancer, liver cancer and prostate cancer. Howev...
Zhang, Hongbin Wang, Yuan Ji, Qiaoxia Cai, Hongmei Liang, Xiangcun Xie, Jiong Li, Hua Wang, Jun Zhu, Guiyun Tian, Erpeng
...
Published in
Oncology Letters
Tumor mutation burden (TMB) is an independent indicator used to select patients sensitive to immunotherapy. The present study aimed to investigate the clinicopathological and molecular characteristics of patients with hypermutant lung cancer to identify an economical, simple and complementary method for predicting TMB and immunotherapy responses. I...
Wang, Chen Wang, Wei Han, Xiaodan Du, Longxia Li, Aili Huang, Guojin
Published in
Oncology Letters
Methyltransferase-like 1 (METTL1) is a transfer RNA and microRNA modifying enzyme. However, its role in lung adenocarcinoma (LUAD) remains unknown. The present study aimed to investigate the effect of METTL1 in LUAD and determine the association between METTL1 expression and prognosis of patients with LUAD. The expression profile of METTL1 in LUAD ...
Wei, Jiahui Zhang, Xuefeng Pan, Huihao He, Song Yuan, Bao Liu, Qing Zhang, Jiabao Ding, Yu
Published in
Oncology Letters
Eupafolin is a flavonoid extracted from common sage. Previous studies have reported that Eupafolin has antioxidant, anti-inflammatory, and anti-tumor effects. However, its role in breast cancer remains unclear. The present study investigated the effects and underlying mechanism of action of Eupafolin using breast cancer cell lines. The effects of E...
Qiao, Feng-Hua Tu, Min Liu, Hong-Yan
Published in
Oncology Letters
Gynecological cancers, including breast, ovarian, uterine, vaginal, cervical and vulvar cancers are among the major threats to modern life, particularly to female health. Long non-coding RNAs (lncRNAs) play critical roles in normal development of organisms, as well as the tumorigenesis process, and metastasis-associated lung adenocarcinoma transcri...
Jung, Hui-Jung Seo, Incheol Jha, Bijay Kumar Suh, Seong-Il Baek, Won-Ki
Published in
Oncology Letters
Miconazole is an antifungal agent that is used for the treatment of superficial mycosis. However, recent studies have indicated that miconazole also exhibits potent anticancer effects in various types of cancer via the activation of apoptosis. The main aim of the present study was to observe the effect of miconazole on autophagic cell death of canc...
