Yang, Zongcheng Yan, Guangxing Zheng, Lixin Gu, Wenchao Liu, Fen Chen, Wei Cui, Xiujie Wang, Yue Yang, Yaling Chen, Xiyan
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Published in
Oncoimmunology
Metastasis and immune suppression account for the poor prognosis of oral squamous cell carcinoma (OSCC). YKT6 is a member of the soluble NSF attachment protein receptor (SNARE) family, and the effect of YKT6 in OSCC remains elusive. The purpose of this study was to explore promising prognostic and immune therapeutic candidate biomarkers for OSCC an...
Gao, Yuzhen Wang, Hao Li, Huiming Ye, Xinxin Xia, Yan Yuan, Shijin Lu, Jie Xie, Xinyou Wang, Liangjing Zhang, Jun
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Published in
Oncoimmunology
Emerging evidence has revealed the crucial role of transcriptional RNA methyladenosine modification in immune response. However, the potential role of RNA N1-methyladenosine (m1A) modification of immune cells in the tumor microenvironment (TME) still remains unclear. In this study, we identified three distinct m1A modification patterns based on the...
Brauneck, F. Haag, F Woost, R. Wildner, N. Tolosa, E. Rissiek, A. Vohwinkel, G. Wellbrock, J. Bokemeyer, C. Schulze zur Wiesch, J.
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Published in
Oncoimmunology
The inhibitory receptor TIGIT, as well as theectonucleotidases CD39 and CD73 constitute potential exhaustion markers for T cells. Detailed analysis of these markers can shed light into dysregulation of the T-cell response in acute myeloid leukemia (AML) and will help to identify potential therapeutic targets. The phenotype and expression of transc...
Kong, Defeng Zhang, Wen Yang, Zhenrong Li, Guoliang Cheng, Shujun Zhang, Kaitai Feng, Lin
Published in
Oncoimmunology
Circulating tumor cells (CTCs) are considered to be related to the prognosis of cancer patients. CTC is a powerful indicator for recurrence or metastasis. The relationship, however, between the expression of programmed cell death receptor ligand 1 (PD-L1) on CTCs in peripheral blood and the prognosis, is still controversial. Here, we conducted a me...
Tata, Angela Dodard, Garvin Fugère, Céline Leget, Corinne Ors, Mélody Rossi, Benjamin Vivier, Eric Brossay, Laurent
Published in
Oncoimmunology
Checkpoint blockade therapy is effective against many cancers; however, new targets need to be identified to treat patients who do not respond to current treatment or demonstrate immune escape. Here, we showed that blocking the inhibitory receptor Killer cell lectin-like receptor G1 (KLRG1) enhances anti-tumor immunity mediated by NK cells and CD8+...
Arra, Aditya Pech, Maximilian Fu, Hang Lingel, Holger Braun, Franziska Beyer, Christian Spiliopoulou, Myra Bröker, Barbara M. Lampe, Karen Arens, Christoph
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Published in
Oncoimmunology
The monoclonal antibody against CTLA-4, Ipilimumab, is a first-in-class immune-checkpoint inhibitor approved for treatment of advanced melanoma in adults but not extensively studied in children. In light of the fact that the immune response early in life differs from that of adults, we have applied a human in vitro model stimulating CD4+ T-cells fr...
Makanga, Dhon Roméo Jullien, Maxime David, Gaëlle Legrand, Nolwenn Willem, Catherine Dubreuil, Léa Walencik, Alexandre Touzeau, Cyrille Gastinne, Thomas Tessoulin, Benoit
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Published in
Oncoimmunology
The antibody-dependent cellular cytotoxicity (ADCC) effector function of natural killer (NK) cells is one of the known mechanisms of action for rituximab-based anti-cancer immunotherapy. Inhibition of the ADCC function of NK cells through interactions between inhibitory killer cell immunoglobulin-like receptors (KIRs) and HLA class I ligands is ass...
Kol, Arjan Lubbers, Joyce M. Terwindt, Anouk L.J. Workel, Hagma H. Plat, Annechien Wisman, G. Bea A. Bart, Joost Nijman, Hans W. De Bruyn, Marco
Published in
Oncoimmunology
Activation of STimulator of INterferon Genes (STING) is important for induction of anti-tumor immunity. A dysfunctional STING pathway is observed in multiple cancer types and associates with poor prognosis and inferior response to immunotherapy. However, the association between STING and prognosis in virally induced cancers such as HPV-positive cer...
Fan, Dandan Yue, Qi Chen, Jian Wang, Cong Yu, Ruilin Jin, Ziyi Yin, Shujie Wang, Qinyue Chen, Luo Liao, Xueling
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Published in
Oncoimmunology
The vast majority (>90%) of glioblastoma (GBM) patients belong to the isocitrate dehydrogenase 1 wild type (IDH1WT) group which exhibits a poor prognosis with a median survival of less than 15 months. This study demonstrated numerous immunosuppressive genes as well as β-catenin gene, pivotal for Wnt/β-catenin signaling, were upregulated in 206 IDH1...
Li, Xiaolei Dai, Hanren Wang, Hua
Published in
Oncoimmunology
The success of checkpoint immunotherapy has created optimism that cancer may be curable. However, not all patients respond, resistance is common and many patients relapse owing to immune escape. We demonstrate that HDAC inhibition not only decreases the trafficking of myeloid-derived suppressor cells (MDSCs) into tumors but also potentiates tumor-a...
