Molina, Ester García-Gutiérrez, Lucía Junco, Vanessa Perez-Olivares, Mercedes de Yébenes, Virginia G Blanco, Rosa Quevedo, Laura Acosta, Juan C Marín, Ana V Ulgiati, Daniela
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Published in
Oncogene
MYC is an oncogenic transcription factor dysregulated in about half of total human tumors. While transcriptomic studies reveal more than 1000 genes regulated by MYC, a much smaller fraction of genes is directly transactivated by MYC. Virtually all Burkitt lymphoma (BL) carry chromosomal translocations involving MYC oncogene. Most endemic BL and a f...
Jiang, Wangjie Yang, Xiao Shi, Kuangheng Zhang, Yaodong Shi, Xiaoli Wang, Jifei Wang, Yuming Chenyan, Anlan Shan, Jijun Wang, Yirui
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Published in
Oncogene
Spindle assembly checkpoint (SAC) plays an essential part in facilitating normal cell division. However, the clinicopathological and biological significance of mitotic arrest deficient 2 like 1 (MAD2/MAD2L1), a highly conserved member of SAC in cholangiocarcinoma (CCA) remain unclear. We aim to determine the role and mechanism of MAD2 in CCA progre...
Liu, Xuesong Lv, Mengzhu Zhang, Weimin Zhan, Qimin
Published in
Oncogene
Cholesterol homeostasis has been implicated in the regulation of cellular and body metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many diseases such as cardiovascular diseases, and neurodegenerative diseases, among others. Recent studies have unveiled the connection between abnormal cholesterol metabolism and can...
Wang, Yijie Liu, Xiong Wang, Min Wang, Yu Wang, Shuo Jin, Lai Liu, Min Zhou, Jun Chen, Yan
Published in
Oncogene
Mutations in E3 ubiquitin ligase UBE3B have been linked to Kaufman Oculocerebrofacial Syndrome (KOS). Accumulating evidence indicates that UBE3B may play an important role in cancer. However, the precise role of UBE3B in cancer and the underlying mechanism remain largely uncharted. Here, we reported that UBE3B is an E3 ligase for hypoxia-inducible ...
Bello Roufai, D Gonçalves, A De La Motte Rouge, T Akla, S Blonz, C Grenier, J Gligorov, J Saghatchian, M Bailleux, C Simon, H
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Published in
Oncogene
SOLAR-1 and BYLieve trials documented the efficacy of the PI3K-inhibitor alpelisib in pre-treated PIK3CA-mutant, hormone receptor-positive, HER2-negative (HR+/HER2-) advanced breast cancer (ABC) patients. We report here real-life data of patients prospectively registered in the French alpelisib early access program (EAP) opened to PIK3CA-mutant HR+...
Koch, Jonas P Roth, Selina M Quintin, Aurélie Gavini, Jacopo Orlando, Eleonora Riedo, Rahel Pozzato, Chiara Hayrapetyan, Liana Aebersold, Ruedi Stroka, Deborah M
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Published in
Oncogene
The DNA damage response (DDR) is intertwined with signaling pathways downstream of oncogenic receptor tyrosine kinases (RTKs). To drive research into the application of targeted therapies as radiosensitizers, a better understanding of this molecular crosstalk is necessary. We present here the characterization of a previously unreported MET RTK phos...
Dhamdhere, Mayura R Gowda, Chethana P Singh, Vikash Liu, Zhenqiu Carruthers, Nicholas Grant, Christa N Sharma, Arati Dovat, Sinisa Sundstrom, Jeffrey M Wang, Hong-Gang
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Published in
Oncogene
Neuroblastoma is a highly metastatic cancer, and thus is one of the leading causes of cancer-related mortalities in pediatric patients. More than 50% of NB cases exhibit 17q21-ter partial chromosomal gain, which is independently associated with poor survival, suggesting the clinical importance of genes at this locus in NB. IGF2BP1 is one such proto...
Liu, Anyi Yu, Chengxin Qiu, Cheng Wu, Qi Huang, Changsheng Li, Xun She, Xiaowei Wan, Kairui Liu, Lang Li, Mao
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Published in
Oncogene
Perturbations in transforming growth factor-β (TGF-β) signaling can lead to a plethora of diseases, including cancer. Mutations and posttranslational modifications (PTMs) of the partner of SMAD complexes contribute to the dysregulation of TGF-β signaling. Here, we reported a PTM of SMAD4, R361 methylation, that was critical for SMAD complexes forma...
Thüring, Eva-Maria Hartmann, Christian Schwietzer, Ysabel A Ebnet, Klaus
Published in
Oncogene
The development of multicellular organisms depends on cell adhesion molecules (CAMs) that connect cells to build tissues. The immunoglobulin superfamily (IgSF) constitutes one of the largest families of CAMs. Members of this family regulate such diverse processes like synapse formation, spermatogenesis, leukocyte-endothelial interactions, or epithe...
An, Ningfei Khan, Saira Imgruet, Molly K Jueng, Lia Gurbuxani, Sandeep McNerney, Megan E
Published in
Oncogene
-7/del(7q) is prevalent across subtypes of myeloid neoplasms. CUX1, located on 7q22, encodes a homeodomain-containing transcription factor, and, like -7/del(7q), CUX1 inactivating mutations independently carry a poor prognosis. As with loss of 7q, CUX1 mutations often occur early in disease pathogenesis. We reported that CUX1 deficiency causes myel...
