Shapira, Shiran Finkelshtein, Eynat Kazanov, Dina Naftali, Esmira Stepansky, Irena Loyter, Abraham Elbirt, Daniel Hay-Levy, Mori Brazowski, Eli Bedny, Faina
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Published in
Oncogene
The integration of viral DNA into the host genome is mediated by viral integrase, resulting in the accumulation of double-strand breaks. Integrase-derived peptides (INS and INR) increase the number of integration events, leading to escalated genomic instability that induces apoptosis. CD24 is a surface protein expressed mostly in cancer cells and i...
Chen, Ze Shao, Yang-Liu Wang, Li-Li Lin, Ji Zhang, Ji-Bin Ding, Yi Gao, Bin-Bin Liu, Dai-Hong Gao, Xiao-Ning
Published in
Oncogene
The t(8;21) fusion product, AML1/ETO, and hypoxia-inducible factor 1α (HIF1α) form a feed-forward transcription loop that cooperatively transactivates the DNA methyltransferase 3a gene promoter that leads to DNA hypermethylation and drives leukemia cell growth. Suppression of the RNA N6-methyladenosine (m6A)-reader enzyme YTH N6-methyladenosine RNA...
Pietrobono, Silvia Gaudio, Eugenio Gagliardi, Sinforosa Zitani, Mariapaola Carrassa, Laura Migliorini, Francesca Petricci, Elena Manetti, Fabrizio Makukhin, Nikolai Bond, Adam G
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Published in
Oncogene
Despite the development of new targeted and immune therapies, the prognosis of metastatic melanoma remains bleak. Therefore, it is critical to better understand the mechanisms controlling advanced melanoma to develop more effective treatment regimens. Hedgehog/GLI (HH/GLI) signaling inhibitors targeting the central pathway transducer Smoothened (SM...
Zhu, Yezi Dalrymple, Susan L Coleman, Ilsa Zheng, S Lilly Xu, Jianfeng Hooper, Jody E Antonarakis, Emmanuel S De Marzo, Angelo M Meeker, Alan K Nelson, Peter S
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Published in
Oncogene
Li, W Hu, M Wang, C Lu, H Chen, F Xu, J Shang, Y Wang, F Qin, J Yan, Q
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Published in
Oncogene
Yusenko, Maria V Trentmann, Amke Casolari, Debora A Abdel Ghani, Luca Lenz, Mairin Horn, Melanie Dörner, Wolfgang Klempnauer, Stefan Mootz, Henning D Arteaga, Maria Francisca
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Published in
Oncogene
Transcription factor MYB has recently emerged as a promising drug target for the treatment of acute myeloid leukemia (AML). Here, we have characterized a group of natural sesquiterpene lactones (STLs), previously shown to suppress MYB activity, for their potential to decrease AML cell proliferation. Unlike what was initially thought, these compound...
Williams, Carly B Phelps-Polirer, Kendall Dingle, Ivan P Williams, Christina J Rhett, Matthew J Eblen, Scott T Armeson, Kent Hill, Elizabeth G Yeh, Elizabeth S
Published in
Oncogene
Zeng, Kaixuan Chen, Xiaoxiang Hu, Xiuxiu Liu, Xiangxiang Xu, Tao Sun, Huiling Pan, Yuqin He, Bangshun Wang, Shukui
Published in
Oncogene
Lv, Yan Wang, Yin Song, Yu Wang, Shu-Sheng Cheng, Kai-Wen Zhang, Zhi-Qing Yao, Jin Zhou, Li-Na Ling, Zhuo-Yan Cao, Cong
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Published in
Oncogene
Gastric cancer (GC) is one of the leading causes of human mortality around the world. We have previously shown that Gαi1 (the inhibitory subunit 1 of the heterotrimeric guanine nucleotide-binding protein) recruitment to ligand-activated receptor tyrosine kinases (RTKs) is essential for signaling. Testing its role in GC cancer-promoting functions, w...
Yu, Zeyuan Jiang, Xiangyan Qin, Long Deng, Haixiao Wang, Jianli Ren, Wen Li, Hongbin Zhao, Lei Liu, Huanxiang Yan, Hong
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Published in
Oncogene
Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt pathway inhibitors being studied in preclinical or clinical settings for other cancers such as colorectal and pancreatic cancers are either too cytotoxic or insufficiently efficacious for GC. Thus, we screened new pot...
