Jin, Ying Bao, Hua Le, Xiuning Fan, Xiaojun Tang, Ming Shi, Xun Zhao, Jun Yan, Junrong Xu, Yang Quek, Kelly
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Published in
Oncogene
The original version of this Article omitted the following from the Acknowledgements: Professor Stebbing sits on SABs for Celltrion, Singapore Biotech, Vor Biopharma, TLC Biopharmaceuticals and Benevolent AI, has consulted with Lansdowne partners, Vitruvian and Social Impact Capital and Chairs the Board of Directors for BB Biotech Healthcare Trust ...
Suzuki, Natsumi Idogawa, Masashi Tange, Shoichiro Ohashi, Tomoko Sasaki, Yasushi Nakase, Hiroshi Tokino, Takashi
Published in
Oncogene
p53 is one of the most important tumor suppressor genes, and the exploration of p53-target genes is important for elucidation of its functional mechanisms. In this study, we identified Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) as a direct target of p53 through ChIP-sequencing analysis. Activated p53 protein was found to b...
Saraç, Hilal Morova, Tunç Pires, Elisabete McCullagh, James Kaplan, Anıl Cingöz, Ahmet Bagci-Onder, Tugba Önder, Tamer Kawamura, Akane Lack, Nathan A.
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Published in
Oncogene
Androgen deprivation therapy (ADT) is the standard care for prostate cancer (PCa) patients who fail surgery or radiotherapy. While initially effective, the cancer almost always recurs as a more aggressive castration resistant prostate cancer (CRPC). Previous studies have demonstrated that chromatin modifying enzymes can play a critical role in the ...
Hazawa, Masaharu Sakai, Kie Kobayashi, Akiko Yoshino, Hironori Iga, Yoshihiro Iwashima, Yuki Lim, Kee Sing Chih-Cheng Voon, Dominic Jiang, Yan-Yi Horike, Shin-ichi
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Published in
Oncogene
Nuclear import, mediated in part by karyopherin-α (KPNA)/importin-α subtypes, regulates transcription factor access to the genome and determines cell fate. However, the cancer-specific changes of KPNA subtypes and the relevancy in cancer biology remain largely unknown. Here, we report that KPNA4, encoding karyopherin-α4 (KPNA4), is exclusively ampl...
Herrmann, Andreas Lahtz, Christoph Song, Jieun Aftabizadeh, Maryam Cherryholmes, Gregory A. Xin, Hong Adamus, Tomasz Lee, Heehyoung Grunert, David Armstrong, Brian
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Published in
Oncogene
Both the extracellular matrix (ECM) and DNA epigenetic regulation are critical for maintaining stem cell phenotype and cancer progression. Whether and how ECM regulates epigenetic alterations to influence cancer stem cells (CSCs) remain to be explored. Here we report that ECM through laminin-integrin α6 upregulates ten-eleven translocation enzyme 3...
Oshikawa, Kiyotaka Matsumoto, Masaki Kodama, Manabu Shimizu, Hideyuki Nakayama, Keiichi I.
Published in
Oncogene
Whereas large T antigen (LT) of simian virus 40 (SV40) promotes oncogenesis by inactivating the tumor suppressor proteins p53 and pRb, SV40 small T antigen (ST) has been thought to be dispensable for this process. However, here we show that LT promotes both oncogenic growth and senescence in human cells expressing oncogenic Ras and that this latter...
Semba, S. Trapasso, F. Fabbri, M. McCorkell, K. A. Volinia, S. Druck, T. Iliopoulos, D. Pekarsky, Y. Ishii, H. Garrison, P. N.
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Published in
Oncogene
After publication of this Article the authors noticed errors in several figures. In Fig. 2b the Gapdh panels are incorrect. The lysates are identical to those used in Fig. 1b, therefore the Gapdh panels should be the same in both figures. In Fig. 3b the Gapdh panels for Ad-Fhit-wt and Ad-Fhit-Y114F are incorrect and have been replaced with scans fr...
Zhou, Qingqing Huang, Tingting Jiang, Zhiyuan Ge, Chao Chen, Xiaoxia Zhang, Lili Zhao, Fangyu Zhu, Miaoxin Chen, Taoyang Cui, Ying
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Published in
Oncogene
Endocytosis is an essential component of cell motility, which facilitates the malignant behavior of cancer. Sorting nexin (SNX) family members are associated with tumor progression. However, the role and mechanism of SNX5 in hepatocellular carcinoma (HCC) progression remain largely unknown. In this study, we investigated the clinical significance a...
Li, Lina Liu, Jian Xue, Hongsheng Li, Chunxiao Liu, Qun Zhou, Yantong Wang, Ting Wang, Haijuan Qian, Haili Wen, Tao
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Published in
Oncogene
MTA1, SOX4, EZH2, and TGF-β are all potent inducers of epithelial–mesenchymal transition (EMT) in cancer; however, the signaling relationship among these molecules in EMT is poorly understood. Here, we investigated the function of MTA1 in cancer cells and demonstrated that MTA1 overexpression efficiently activates EMT. This activation resulted in a...
Zhang, Mingliang Lin, Xiao Zhang, Jinping Su, Lin Ma, Mingming Ea, Vicki L. Liu, Xun Wang, Liming Chang, Jin Li, Xiaorong
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Published in
Oncogene
Uveal melanoma is the most common intraocular primary malignancy in adults and has been considered a fatal disease for decades. Optogenetics is an emerging technique that can control the activation of signaling components via irradiation with visible light. The clinical translation of optogenetics has been limited because of the need for surgical i...
