Chen, Yifan Liu, Ji Zhang, Wentao Kadier, Aimaitiaji Wang, Ruiliang Zhang, Haimin Yao, Xudong
Published in
OncoTargets and therapy
Objective NUSAPl and O-GlcNAcylation were reported to be hyper-activated in many kinds of cancers and involved in the advanced progression of cancers. In bladder cancer, O-GlcNAc transferase (OGT) expresses in patients’ urine samples, with no expression in healthy individuals, indicating O-GlcNAcylation might involve in the occurrence and developme...
Zheng, Qiaoling Zhang, Jianyong Wang, Xinchen Zhang, Wenxiong Xiao, Yipo Hu, Sheng Xu, Jianjun
Published in
OncoTargets and therapy
Purpose Increased use of low-dose spiral computed tomography (LDCT: low-dose computed tomography) screening has contributed to more frequent incidental detection of peripheral lung nodules, part of them were adenocarcinoma, which need to be further evaluated to establish a definitive diagnosis. Here, our primary objective was to evaluate the ambien...
Rodrigues-Junior, Dorival Mendes Pelarin, Maria Fernanda de Andrade Nader, Helena Bonciani Vettore, André Luiz Pinhal, Maria Aparecida Silva
Published in
OncoTargets and therapy
Introduction Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy’s molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus, targeting HPSE seems to be a promising approach for...
Han, Anna Xu, Ran Liu, Ying Yin, Xianglin Lin, Zhenhua Yang, Wanshan
Published in
OncoTargets and therapy
Background Pancreatic cancer (PC) is a leading cause of cancer mortality worldwide. Hydroxysteroid dehydrogenase like protein 2 (HSDL2) is overexpressed in a variety of malignant tumors and is might be closely related to the development of cancer. It also regulates different metabolism and signaling pathways. Purpose The purpose of this research wa...
Wei, Jingsun Qian, Yucheng Tang, Yang Ge, Xiaoxu Jiang, Kai Fang, Yimin Fu, Dongliang Kong, Xiangxing Xiao, Qian Ding, Kefeng
...
Published in
OncoTargets and therapy
Purpose N6-methyladenosine (m6A) modifications represent one of the most common methylation modifications, and they are mediated by m6A RNA methylation regulators. However, their functions in renal cell carcinoma (RCC) are not completely understood. The aim of this study was to investigate the effects of the regulators in RCC. Materials and Methods...
Zhang, Chunhe Fu, Shaowei Wang, Luyue Wang, Fang Wu, Dan Zhe, Xiangyi Xin, Huizhen Li, Hongtao Li, Dongmei Jin, Fuyuan
...
Published in
OncoTargets and therapy
Introduction The aim of this study was to determine whether ZNF582 gene methylation and tissue protein expression can be used as a tool with high sensitivity and specificity for cervical cancer screening. We analyzed the correlation between promoter methylation of ZNF582 gene and cervical cancer and high risk HPV16/18 infection. Methods Tissue samp...
Nie, Xiao-Cui He, Fang Lan, Chong Niu, Ju-Min Xia, Pu
Published in
OncoTargets and therapy
Introduction Ovarian cancer (OV) can seriously endanger women’s physical and mental health. Serum DKK3 has been used for the diagnosis and prognosis of patients with ovarian cancer. However, the specificity of antibodies may lead to errors in the detection of plasma protein. Methods Circulating CD133+ cells from blood samples were separated by magn...
Ren, Lu Yang, Shaoqin Cao, Qinxue Tian, Jun
Published in
OncoTargets and therapy
Background Cervical cancer is a lethal gynecologic cancer in women. Long non-coding RNA colorectal neoplasia differentially expressed (LncRNA CRNDE) was recognized as a significant oncogene in multiple cancers. However, the functional role of CRNDE in cervical cancer remains poorly explored. Methods The expression of CRNDE, microRNA-4262 (miR-4262)...
Grossmann, Nico C Schuettfort, Victor M Pradere, Benjamin Moschini, Marco Quhal, Fahad Mostafaei, Hadi Soria, Francesco Katayama, Satoshi Laukhtina, Ekaterina Mori, Keiichiro
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Published in
OncoTargets and therapy
Purpose The Plasminogen Activation System (PAS) plays a role in tumor growth, invasion and metastasis and has been associated with oncological outcomes in urinary bladder carcinoma (UBC). The use of the different components of this system as molecular markers could improve our understanding of the heterogeneous behavior of UBC and might enable earl...
Liu, Jing Huang, Shimei Liao, Xin Chen, Zhongsheng Li, Lianghe Yu, Lei Zhan, Wei Li, Rui
Published in
OncoTargets and therapy
Background Ewing sarcoma-associated transcript 1 ( EWSAT1 ) has been reported to be a pivotal modulator in a series of cancers. However, the function of EWSAT1 in colorectal cancer (CRC) has not been elaborated. This study aimed to explore the role of EWSAT1 in CRC progression and the underlying mechanisms. Methods The expression patterns of EWSAT1...