Published in Neurotoxicology and Teratology
•Zebrafish and mammalian physiology and development are strikingly similar.•Zebrafish is predictive of mammalian toxic responses.•Zebrafish is increasingly used for in vivo drug discovery.•FDA & EMEA have accepted zebrafish toxicity & safety data for IND approval.•A number of new drugs discovered in zebrafish models are now in clinical trials.
Published in Neurotoxicology and Teratology
•Largest ever epidemiologic study of ambient hydrogen sulfide (H2S) exposure and cognitive function in a number of key domains•Extensive exposure assessment, for both current exposure and last 30years of exposure•No evidence was found for an association of H2S with cognitive dysfunction in any domain.
Published in Neurotoxicology and Teratology
Published in Neurotoxicology and Teratology
•Notch target gene E(spl)mδ shows muscle specific expression in Drosophila.•Methylmercury perturbs embryonic neuron and muscle development in Drosophila.•Upregulated E(spl)mδ activity in developing muscle alters muscle development
Published in Neurotoxicology and Teratology
•Persistent PCBs in the blood serum of 271 Mohawk adolescents were measured.•Two rating scales of ADHD-like behavior were completed by parents and teachers.•PCB levels were not related to ratings of ADHD-like behavior.•There was no evidence of negative confounding by SES or breastfeeding history.
Published in Neurotoxicology and Teratology
•Rats orally treated with methylphenidate (MPH) (6, 18, or 42mg/kg/day) on GDs 6–21•On PNDs 1–21, all pups/litter orally treated with the same dose dam had received.•Serum MPH levels of 6mg/kg/day dams within range of therapeutic doses in adults•Serum MPH levels in offspring were substantially higher.•No MPH effects on PNDs 3–6 righting reflex or P...
Published in Neurotoxicology and Teratology
•The use of ethanol-blended gasoline has raised concerns for potential health effects from inhalation of ethanol vapors.•The developing nervous system is sensitive to ethanol exposure.•Pregnant rats were exposed by inhalation to clean air or three concentrations of ethanol vapors.•As adults the exposed pups were tested with a series of neurophysiol...
Published in Neurotoxicology and Teratology
•Longitudinal study of early neurodevelopment in New Zealand children exposed prenatally to methamphetamine•Methamphetamine exposure was associated with lower motor scores on two standardized measures of motor development.•No significant association was found between methamphetamine exposure and cognitive outcomes.•Males of Maori descent performed ...
Published in Neurotoxicology and Teratology
•Prenatal exposure to methylmercury is known to cause a neurotoxicity risk•Lower postnatal exposure is of uncertain risk and correlates with prenatal exposure•Mutual adjustment of error-prone exposure variables appears inappropriate•Postnatal visuospatial deficits are suggested by structural equation modeling
Published in Neurotoxicology and Teratology
•Botanical estrogens are marketed to midlife women as an aide to healthy aging.•The efficacy of the botanical estrogen S-equol to alter cognition was assessed.•Middle-aged ovariectomized (OVX) rats were treated with S-equol.•Rats were tested on a prefrontal working memory or hippocampal place learning task.•S-equol treatment did not alter learning ...
