Zhu, Jun-Jing Xu, Yi-Qiao He, Jian-Hui Yu, Hang-Ping Huang, Chang-Jiang Gao, Ji-Min Dong, Qiao-Xiang Xuan, Yao-Xian Li, Chun-Qi
Published in
Journal of applied toxicology : JAT
Cardiovascular toxicity is a major challenge for the pharmaceutical industry and predictive screening models to identify and eliminate pharmaceuticals with the potential to cause cardiovascular toxicity in humans are urgently needed. In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular tox...
Reed, Bruce R. Crane, Julian Garrett, Nick Woods, David L. Bates, Michael N.
Published in
Neurotoxicology and Teratology
Abu-Taweel, Gasem M. A., Zyadah M. Ajarem, Jamaan S. Ahmad, Mohammad
Published in
Neurotoxicology and Teratology
•Monosodium glutamate (MSG) and Aspartame (ASM) are tested for toxicity in male rats.•MSG and ASM individually and jointly disrupt cognitive capabilities.•These cognitive behaviors are controlled by hippocampus and striatum (in forebrain).•MSG and ASM jointly affect neurotransmitters and oxidative stress in forebrain.•MSG and ASM are more neurotoxi...
Published in
Neurotoxicology and Teratology
Engel, Gregory L. Rand, Matthew D.
Published in
Neurotoxicology and Teratology
Rugless, Fedoria Bhattacharya, Amit Succop, Paul Dietrich, Kim N Cox, Cyndy Alden, Jody Kuhnell, Pierce Barnas, Mary Wright, Robert Parsons, Patrick J
...
Published in
Neurotoxicology and teratology
Airborne manganese (Mn) exposure can result in neurotoxicity and postural instability in occupationally exposed workers, yet few studies have explored the association ambient exposure to Mn in children and postural stability. The goal of this study was to determine the association between Mn and lead (Pb) exposure, as measured by blood Pb, blood an...
Neese, Steven L Pisani, Samantha L Doerge, Daniel R Helferich, William G Sepehr, Estatira Chittiboyina, Amar G Rotte, Sateesh Chandra Kumar Smillie, Troy J Khan, Ikhlas A Korol, Donna L
...
Published in
Neurotoxicology and teratology
The use of over-the-counter botanical estrogens containing isolated soy isoflavones, including genistein and daidzein, has become a popular alternative to traditional hormone therapies. Menopausal women use these products as an aide in healthy aging, including for the maintenance of cognitive function. The safety and efficacy of many of these comme...
Parajuli, Rajendra P. Fujiwara, Takeo Umezaki, Masahiro Furusawa, Hana Watanabe, Chiho
Published in
Neurotoxicology and Teratology
•In this cohort, cord blood arsenic (As) level was lower than the reported level in Asia.•Cord blood lead (Pb) & zinc (Zn) levels were similar to the reported levels in Asia.•Cord blood Pb, As, & Zn levels were not associated with Bayley scores at 6months.•Infants with relatively stimulating home environment exhibited better motor scores.•Associati...
Sadowski, Renee N. Park, Pul Neese, Steven L. Ferguson, Duncan C. Schantz, Susan L. Juraska, Janice M.
Published in
Neurotoxicology and Teratology
•Pregnant females received 0, 4, 40, or 400μg/kg/day BPA throughout gestation.•Male and female offspring were orally given the same dose from postnatal days 1–9.•As adults, rats were trained on the 17-arm radial maze with baited and unbaited arms.•BPA did not significantly alter adult performance in either males or females.•BPA doses of 4 and 400μg...
Published in
Neurotoxicology and Teratology
Abstract The impact of early postnatal lead exposure measured at age 4 on children's IQ and academic achievement at and 11 years of age was examined. The sample consisted of 278 inner-city, primarily African American children who were polydrug exposed prenatally. Regression analyses indicated a linear effect of lead exposure on outcomes and no mode...
