Das, Mamali Jaya Balan, Devasahayam Kasi, Pandima Devi
Published in
Neurotoxicology
The present work describes the neuroprotective efficacy of DHAc under escalated oxidative stress condition in scopolamine-induced amnesic mice. During the toxicity test of DHAc in mice, the acute dose (LD50) is found to be 3.468 mg/kg bw and the sub-acute dose is 0.68 mg/kg bw. Improved cognitive and learning abilities are observed in Morris water ...
Adaya, Daniela Silva Garza-Lombó, Carla Gonsebatt, María E
Published in
Neurotoxicology
Organisms have metabolic pathways responsible for eliminating endogenous and exogenous toxicants. Generally, we associate the liver par excellence as the organ in charge of detoxifying the body; however, this process occurs in all tissues, including the brain. Due to the presence of the blood-brain barrier (BBB) and the blood-cerebrospinal fluid ba...
Corrêa, Mariana Lima Soares, Pedro San Martin da Silva, Bruna Gonçalves Cordeiro Wehrmeister, Fernando Horta, Bernardo Lessa Menezes, Ana Maria Baptista
Published in
Neurotoxicology
Exposure to tobacco during pregnancy may disrupt fetal brain development and impact offspring cognitive development. To perform a systematic review and meta-analysis on maternal smoking during pregnancy and intelligence quotient (IQ) in childhood, adolescence, and adulthood. We searched PubMed, Lilacs, PsycINFO, and Web of Science. Original article...
Wu, Huan-Tong Yu, Yun Li, Xi-Xi Lang, Xiu-Yuan Gu, Run-Ze Fan, Sheng-Rui Fang, Xin Bai, Jin-Peng Lan, Rongfeng Qin, Xiao-Yan
...
Published in
Neurotoxicology
Edaravone (Eda) is a free radical scavenger used in clinical trials for the treatment of ischemic stroke and amyotrophic lateral sclerosis. However, how Eda exerts its neuroprotective effects remains to be elucidated. We investigated the neuroprotective effects of Eda in cultured hippocampal neurons and in a mouse model of AlCl3/D-galactose-induced...
Janner, Dieniffer Espinosa Gomes, Nathalie Savedra Poetini, Márcia Rósula Poleto, Kétnne Hanna Musachio, Elize Aparecida Santos de Almeida, Francielli Polet de Matos Amador, Elen Caroline Reginaldo, Jocemara Corrêa Ramborger, Bruna Piaia Roehrs, Rafael
...
Published in
Neurotoxicology
Neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) are responsible for behavioral deficits in children. Imidacloprid is a nicotinic acetylcholine receptor agonist, capable of causing behavioral changes in Drosophila melanogaster, similar to the ADHD-like phenotypes. We assess whe...
Wang, Si Liu, Huan Cheng, Boli Wu, Qionghui Li, Lisha Yang, Ting Hou, Nali Li, Tingyu
Published in
Neurotoxicology
Motor dysfunctions are common comorbidities among autism spectrum disorder (ASD) patients. Abnormal cerebellar development throughout critical periods may have an effect on motor functions and result in motor impairments. Vitamin A (VA) plays a crucial role in the developing process of the nervous system. The correlation of VA deficiency (VAD) and ...
Abdel Salam, Manal E Elawady, Eglal H Khater, Aya S Eweda, Sara A Abd El Moneam, Mohamed H
Published in
Neurotoxicology
Acute carbon monoxide (CO) poisoning is one of the most common poisons worldwide and neuropsychiatric sequelae (NS) are the most frequent form of its morbidity. This study aimed to measure the percentage of patients liable to NS, to evaluate the cognitive profile of patients with NS and to assess the role of neuron specific enolase (NSE) and glial ...
Hadizadeh-Bazaz, Mahboobeh Vaezi, Golamhassan Khaksari, Mehdi Hojati, Vida
Published in
Neurotoxicology
Methamphetamine is used extensively around the world as a psychostimulant. The complications related to methamphetamine include methamphetamine-induced neurotoxicity, mainly involving intraneuronal processes, such as oxidative stress and excitotoxicity. Curcumin is effective against neuronal injury due to its antioxidant, anti-inflammatory effects....
Sodhi, Rupinder Kaur Bansal, Yashika Singh, Raghunath Saroj, Priyanka Bhandari, Ranjana Kumar, Baldeep Kuhad, Anurag
Published in
Neurotoxicology
Parkinson's disease (PD), a common neurodegenerative motor disorder characterized by striatal dopaminergic neuronal loss and localized neuroinflammation in the midbrain region. Activation of microglia is associated with various inflammatory mediators and Kynurenine pathway (KP) being one of the major regulator of immune response, is involved in the...
Desforges, J P Mikkelsen, B Dam, M Rigét, F Sveegaard, S Sonne, C Dietz, R Basu, N
Published in
Neurotoxicology
Mercury is a neurotoxic chemical that represents one of the greatest pollution threats to Arctic ecosystem health. Evaluating the direct neurotoxic effects of mercury in free ranging wildlife is challenging, necessitating the use of neurochemical biomarkers to assess potential sub-clinical neurological changes. The objective of this study was to ch...
