The critical importance of basic animal research for neuropsychiatric disorders
Published in Neuropsychopharmacology
Impulsivity in Gambling Disorder and problem gambling: a meta-analysis
Published in Neuropsychopharmacology
Gambling Disorder is a prevalent psychiatric condition often linked to dysfunction of cognitive domains regulating impulsive behavior. Despite the centrality of impulsivity to neurobiological models of Gambling Disorder, a comprehensive meta-analysis of all impulsive cognitive domains has yet to be conducted. It is also not clear whether cognitive ...
Voluntary oral consumption of Δ9-tetrahydrocannabinol by adolescent rats impairs reward-predictive cue behaviors in adul...
Published in Neuropsychopharmacology
Few preclinical approaches are available to study the health impact of voluntary consumption of edibles containing the psychoactive drug Δ9-tetrahydrocannabinol (THC). We developed and validated such approach by measuring voluntary oral consumption of THC-containing gelatin by rats and used it to study if and how THC consumption during adolescence ...
Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus mon...
Published in Neuropsychopharmacology
Alcohol use disorder (AUD) persists as a devastating public health problem; widely effective pharmacological treatments are needed. Evidence from rodent models suggests that stimulating brain receptors for the neuropeptide nociceptin/orphanin FQ (NOP) can decrease ethanol drinking. We characterized the effects of the mu opioid peptide (MOP) recepto...
Trace amine-associated receptor 1 agonism promotes wakefulness without impairment of cognition in Cynomolgus macaques
Published in Neuropsychopharmacology
Trace amine-associated receptor 1 (TAAR1) is a G-protein coupled receptor with affinity for the trace amines. TAAR1 agonists have pro-cognitive, antidepressant-, and antipsychotic-like properties in both rodents and non-human primates (NHPs). TAAR1 agonism also increases wakefulness and suppresses rapid-eye movement (REM) sleep in mice and rats and...
Intact responses to non-drug rewards in long-term opioid maintenance treatment
Published in Neuropsychopharmacology
Disruption of non-drug reward processing in addiction could stem from long-term drug use, addiction-related psychosocial stress, or a combination of these. It remains unclear whether long-term opioid maintenance treatment (OMT) disrupts reward processing. Here, we measured subjective and objective reward responsiveness in 26 previously heroin-addic...
Alcohol withdrawal drives depressive behaviors by activating neurons in the rostromedial tegmental nucleus
Published in Neuropsychopharmacology
Rostromedial tegmental nucleus (RMTg) GABA neurons exert a primary inhibitory drive onto midbrain dopamine neurons and are excited by a variety of aversive stimuli. There is, however, little evidence that the RMTg-ventral tegmental area (VTA)-nucleus accumbens shell (Acb) circuit plays a role in the aversive consequences of alcohol withdrawal. This...
Correction: Let’s call the whole thing off: evaluating gender and sex differences in executive function
Published in Neuropsychopharmacology
An error was made in our referencing.
Females pay a higher price for addiction
Published in Neuropsychopharmacology
Naomi Breslau
Published in Neuropsychopharmacology
