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Sleep in Parkinson’s disease

Published in Neuropsychopharmacology

Sleep disturbances are common in Parkinson’s disease and comprise the entire spectrum of sleep disorders. On the one hand regulation of sleep and wakefulness is affected in Parkinson’s disease, leading to the development of disorders, such as insomnia and daytime sleepiness. While on the other hand control of motor activity during sleep is impaired...

Selection criteria for neurophysiologic biomarkers to accelerate the pace of CNS therapeutic development

Published in Neuropsychopharmacology

Linking actions with their consequences within the ventrolateral orbital cortex

Published in Neuropsychopharmacology

Targeting neuroinflammation with brain penetrant P2X7 antagonists as novel therapeutics for neuropsychiatric disorders

Published in Neuropsychopharmacology

Spatial transcriptomics: putting genome-wide expression on the map

Published in Neuropsychopharmacology

Contributions of nonneuronal brain cells in substance use disorders

Published in Neuropsychopharmacology

Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework

Published in Neuropsychopharmacology

The development of alcohol use disorder (AUD) involves binge or heavy drinking to high levels of intoxication that leads to compulsive intake, the loss of control in limiting intake, and a negative emotional state when alcohol is removed. This cascade of events occurs over an extended period within a three-stage cycle: binge/intoxication, withdrawa...

Is depression a disorder of electrical brain networks?

Published in Neuropsychopharmacology

Physiological roles for neuromodulation via Gi/o GPCRs working through Gβγ–SNARE interaction

Published in Neuropsychopharmacology

Brain function during stages of working memory in schizophrenia and psychotic bipolar disorder

Published in Neuropsychopharmacology

Working memory (WM) is impaired in psychotic disorders and linked to functional outcome. Most neurobiological models emphasize prefrontal cortex (PFC) dysfunction in the etiology of WM impairment. However, WM is composed of multiple processes, including encoding and maintenance, and the delineation of the neurobiology of these sub-processes has not...