Linking cell types to behavior in the vertebrate hypothalamus
Published in Neuropsychopharmacology
Applied natural language processing in mental health big data
Published in Neuropsychopharmacology
Imaging suicidal thoughts and behavior: the promise of computational models
Published in Neuropsychopharmacology
Advances in the computational understanding of mental illness
Published in Neuropsychopharmacology
Computational psychiatry is a rapidly growing field attempting to translate advances in computational neuroscience and machine learning into improved outcomes for patients suffering from mental illness. It encompasses both data-driven and theory-driven efforts. Here, recent advances in theory-driven work are reviewed. We argue that the brain is a c...
The ABCD study: understanding the development of risk for mental and physical health outcomes
Published in Neuropsychopharmacology
Following in the footsteps of other large “population neuroscience” studies, the Adolescent Brain Cognitive Development℠ (ABCD) study is the largest in the U.S. assessing brain development. The study is examining approximately 11,875 youth from 21 sites from age 9 to 10 for approximately ten years into young adulthood. The ABCD Study® has completed...
Digital health data-driven approaches to understand human behavior
Published in Neuropsychopharmacology
Advances in digital technologies and data analytics have created unparalleled opportunities to assess and modify health behavior and thus accelerate the ability of science to understand and contribute to improved health behavior and health outcomes. Digital health data capture the richness and granularity of individuals’ behavior, the confluence of...
Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin
...Published in Neuropsychopharmacology
There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions of the self-experience, like depression. Accumulating preclinical evidence emphasizes the role of the glutamate system in the acute action of the drug on brain and behavior; however this has never been tested i...
Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administra...
Published in Neuropsychopharmacology
Methocinnamox (MCAM), a mu opioid receptor antagonist with a long duration of action, attenuates heroin self-administration in rhesus monkeys, suggesting it could be an effective treatment for opioid use disorder (OUD). This study examined effects of acute and repeated MCAM administration on self-administration of the high-efficacy mu opioid recept...
Stimulation of muscarinic acetylcholine M1 receptors reallocates choice between cocaine and an alternative reinforcer
Published in Neuropsychopharmacology
Optimizing behavior therapy for youth with Tourette’s disorder
Published in Neuropsychopharmacology
Tourette’s Disorder (TD) is characterized by tics that cause distress and impairment. While treatment guidelines recommend behavior therapy as a first-line intervention, patients with TD may exhibit limited therapeutic response. Given the need to improve treatment outcomes, this study examined the efficacy of augmenting behavior therapy with d-cycl...
