Karila, Laurent Leroy, Claire Dubol, Manon Trichard, Christian Mabondo, Audrey Marill, Catherine Dubois, Albertine Bordas, Nadège Martinot, Jean-Luc Reynaud, Michel
...
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Modafinil is a candidate compound for the treatment of cocaine addiction that binds to the dopamine transporter (DAT) in healthy humans, as observed by positron emission tomography (PET). This mechanism, analogous to that of cocaine, might mediate a putative therapeutic effect of modafinil on cocaine dependence, though the binding of modafinil to D...
Karila, Laurent Leroy, Claire Dubol, Manon Trichard, Christian Mabondo, Audrey Marill, Catherine Dubois, Albertine Bordas, Nadège Jean-Luc Martinot Reynaud, Michel
...
Published in
Neuropsychopharmacology
Dandash, Orwa Harrison, Ben J Adapa, Ram Gaillard, Raphael Giorlando, Francesco Wood, Stephen J Fletcher, Paul C Fornito, Alex
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
The psychotomimetic effect of the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine is thought to arise from a functional modulation of the brain's fronto-striato-thalamic (FST) circuits. Animal models suggest a pronounced effect on ventral 'limbic' FST systems, although recent work in patients with psychosis and high-risk individuals sugge...
Lopes, Antonio Carlos Greenberg, Benjamin D Norén, Georg Canteras, Miguel Montes Busatto, Geraldo F de Mathis, Maria Eugênia Taub, Anita D'Alcante, Carina Chaubet Hoexter, Marcelo Queiroz Gouvea, Fernando Sauerbronn
...
Published in
The Journal of neuropsychiatry and clinical neurosciences
A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patien...
Jentsch, James David Trantham-Davidson, Heather Jairl, Corey Tinsley, Matthew Cannon, Tyrone D Lavin, Antonieta
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Behavioral genetic studies of humans have associated variation in the DTNBP1 gene with schizophrenia and its cognitive deficit phenotypes. The protein coded for by DTNBP1, dysbindin, is expressed within forebrain glutamatergic neurons, in which it interacts with proteins involved in vesicular trafficking and exocytosis. In order to further delineat...
Boldrini, Maura Underwood, Mark D Hen, René Rosoklija, Gorazd B Dwork, Andrew J John Mann, J Arango, Victoria
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) increase neurogenesis in the dentate gyrus (DG) of rodents and nonhuman primates. We determined whether SSRIs or TCAs increase neural progenitor (NPCs) and dividing cells in the human DG in major depressive disorder (MDD). Whole frozen hippocampi from untreated sub...
Kuczenski, Ronald Segal, David S Melega, William P Lacan, Goran McCunney, Stanley J
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Bingeing is one pattern of high-dose methamphetamine (METH) abuse, which involves continuous drug taking over several days and can result in psychotic behaviors for which the brain pathology remains poorly defined. A corresponding animal model of this type of METH exposure may provide novel insights into the neurochemical and behavioral sequelae as...
Oh, Ji-eun Zupan, Bojana Gross, Steven Toth, Miklos
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Depression, anxiety, and conduct disorders are common in children and adolescents, and selective serotonin reuptake inhibitors (SSRIs) are often used to treat these conditions. Fluoxetine (Prozac) is the first approved SSRI for the treatment of depression in this population. Although it is believed that overall, fluoxetine is effective in child and...
Simmons, Diana Self, David W
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Earlier studies suggest that opioid receptors in the ventral tegmental area, but not the nucleus accumbens (NAc), play a role in relapse to drug-seeking behavior. However, environmental stimuli that elicit relapse also release the endogenous opioid beta-endorphin in the NAc. Using a within-session extinction/reinstatement paradigm in rats that self...
Xu, Qing Huang, Weihua Payne, Thomas J Ma, Jennie Z Li, Ming D
Published in
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Although it has been documented that dynamin 1 gene (DNM1) is significantly modulated by nicotine in animal models, its association with nicotine dependence (ND) in human population remained to be unexplored. To determine whether DNM1 is associated with ND, in this study, we genotyped seven single-nucleotide polymorphisms (SNPs) within this gene in...
