Chung, Ji-Yeon Yoon, Hyung-Jun Kim, Hoowon Choi, Kyu Yeong Lee, Jang Jae Lee, Kun Ho Seo, Eun Hyun
Published in
Neuropsychiatric disease and treatment
Relatively little attention has been paid to the meaning of reversion from mild cognitive impairment (MCI) to cognitively normal (CN), compared to MCI progression studies. The purpose of the study was to investigate the characteristics contributing to reversion from MCI to CN and to identify the associated factors with such reversion. We retrospect...
Gong, Qi Ye, Liping Gui, Huiwen Liu, Jing Li, Huanyin Sun, Qian
Published in
Neuropsychiatric disease and treatment
Stroke ranks as the third-leading cause of years of life lost worldwide. ANGPTL3 plays important roles in lipid metabolism, atherosclerosis, and occurrence of stroke. The purpose of this study was to evaluate associations of genetic variants in the ANGPTL3 gene with ischemic stroke (IS) risk. A case-control study was conducted to evaluate the assoc...
Correll, Christoph U Jain, Rakesh Meyer, Jonathan M Periclou, Antonia Carrothers, Timothy Barabássy, Ágota Patel, Mehul Earley, Willie
Published in
Neuropsychiatric disease and treatment
To explore the timing of relapse following drug discontinuation and its relationship to estimated plasma levels and elimination half-life by comparing data from a randomized, placebo-controlled discontinuation study of cariprazine with those from similarly designed and conducted randomized control trials of other oral atypical antipsychotics (AAPs)...
Mehrabian, Shima Schwarzkopf, Larissa Auer, Stefanie Holmerova, Iva Kramberger, Milica G Boban, Marina Stefanova, Elka Tudose, Catalina Bachinskaya, Natalia Kovács, Tibor
...
Published in
Neuropsychiatric disease and treatment
Dementia is a particularly severe societal challenge in several countries of the Danube Region due to higher-than-average increment in population longevity, disproportionate increase of the old-age dependency ratio, and selective outward migration of health care professionals. A survey was conducted among dementia experts to obtain a deeper underst...
Katsuki, Asuka Kakeda, Shingo Watanabe, Keita Igata, Ryohei Otsuka, Yuka Kishi, Taro Nguyen, LeHoa Ueda, Issei Iwata, Nakao Korogi, Yukunori
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Published in
Neuropsychiatric disease and treatment
Recently, a genome-wide association study successfully identified genetic variants associated with major depressive disorder (MDD). The study identified 17 independent single-nucleotide polymorphisms (SNPs) significantly associated with diagnosis of MDD. These SNPs were predicted to be enriched in genes that are expressed in the central nervous sys...
Zhong, He-Ying Yang, Zhou Qiu, Zhen Lei, Shao-Qing Xia, Zhong-Yuan
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Neuropsychiatric disease and treatment
In this study, the neuroprotective mechanism of 2-arachidonoylglycerol 2-AG against non-caspase-dependent apoptosis in mice hippocampal neurons following MCAO was investigated. One hundred and fifty healthy clean male C57BL/6 mice were randomly divided into 3 groups: sham group, model group and 2-AG treatment group, 50 mice in each group. A modifie...
Zhang, Zhongsheng Liu, Shuangfeng Huang, Sichun
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Neuropsychiatric disease and treatment
This study investigated whether thymosin (T) β4 protects against oxygen-glucose deprivation/reperfusion (OGD/R) injury in rat cortical neurons, as well as the underlying mechanisms. Primary rat cortical neurons were transfected with Tβ4 overexpression plasmid; the transfection efficiency was confirmed by detecting Tβ4 expression by fluorescence qua...
Kalaria, Shamir N Kelly, Deanna L
Published in
Neuropsychiatric disease and treatment
Although clozapine has demonstrated superior efficacy in patients with schizophrenia and other serious mental health illness, drug utilization rates are significantly low due to safety concerns and administration challenges. Previous research indicates that current barriers to clozapine use include lack of confidence and knowledge by prescriber, th...
Robertson, Andrew D Udow, Sean J Espay, Alberto J Merola, Aristide Camicioli, Richard Lang, Anthony E Masellis, Mario
Published in
Neuropsychiatric disease and treatment
Orthostatic hypotension (OH) is a common condition, particularly in patients with α-synucleinopathies such as Parkinson's disease, and has a significant impact on activities of daily living and quality of life. Recent data suggest an association with cognitive impairment. Herein, we review the evidence that OH increases the odds of incident mild co...
Wang, Min Wei, Jinxue Yang, Xiao Ni, Peiyan Wang, Yingcheng Zhao, Liansheng Deng, Wei Guo, Wanjun Wang, Qiang Li, Tao
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Published in
Neuropsychiatric disease and treatment
Purpose: Major depression disorder (MDD) was associated with inflammatory processes, but association results of inflammatory syndrome and MDD were inconsistent. To provide more evidence, we measured the plasma levels of IL-1β, IL-6, interferon (INT)-α2, INT-γ, and tumor necrosis factor (TNF)-α in patients having MDD and explored correlations betwee...
