Bender, Brooke N Torregrossa, Mary M
Published in
Neuropharmacology
Cue exposure therapy (CET) reduces craving induced by drug-associated cues in individuals with substance use disorders. A preclinical model of CET, cue extinction, similarly reduces cue-induced cocaine seeking in rodent self-administration models; however, those models may not capture the habitual or compulsive aspects of drug use. Thus, the effect...
Sanathara, Nayna Alhassen, Lamees Marmouzi, Ilias Khoudari, Mohammad Phan, Joseph Alhassen, Wedad Civelli, Olivier Alachkar, Amal
Published in
Neuropharmacology
Oxytocin regulates social behaviors and has been linked to the etiology of autism and schizophrenia. Oxytocin and another hypothalamic neuropeptide, melanin concentrating hormone (MCH), share several physiological actions such as emotion, social behavior and recognition, maternal care, sexual behavior and stress, which suggests that these two syste...
Cathala, Adeline Devroye, Céline Robert, Éléa Vallée, Monique Revest, Jean-Michel Artigas, Francesc Spampinato, Umberto
Published in
Neuropharmacology
Serotonin2B receptor (5-HT2BR) antagonists inhibit cocaine-induced hyperlocomotion independently of changes of accumbal dopamine (DA) release. Given the tight relationship between accumbal DA activity and locomotion, and the inhibitory role of medial prefrontal cortex (mPFC) DA on subcortical DA neurotransmission and DA-dependent behaviors, it has ...
Paes, Dean Xie, Keqiang Wheeler, Damian G Zook, Douglas Prickaerts, Jos Peters, Marco
Published in
Neuropharmacology
Phosphodiesterases (PDE) are the only enzymes that degrade cAMP and cGMP which are second messengers crucial to memory consolidation. Different PDE inhibitors have been developed and tested for their memory-enhancing potential, but the occurrence of side effects has hampered clinical progression. As separate inhibition of the PDE2 and PDE4 enzyme f...
Laviolette, Steven R
Published in
Neuropharmacology
Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently regulate the transmission of vari...
Xu, Hang Wang, Jiesi Jing, Haiyang Ellenbroek, Bart Shao, Feng Wang, Weiwen
Published in
Neuropharmacology
Depression with comorbid anxiety or cognitive symptoms can vary in terms of symptoms, pathophysiology and antidepressant efficacy, but the underlying neurobiological mechanisms remain to be elucidated. Previous studies from our group and others have shown that as a classic animal model of depression, adolescent social stress (ASS) could stably indu...
Cui, Yan-Hui Fu, Ao Wang, Xue-Qin Tu, Bo-Xuan Chen, Kang-Zhi Wang, Yi-Kai Hu, Qiong-Gui Wang, Lai-Fa Hu, Zhao-Lan Pan, Pin-Hua
...
Published in
Neuropharmacology
Substantial evidence has revealed that abnormalities in synaptic plasticity play important roles during the process of depression. LASP1 (LIM and SH3 domain protein 1), a member of actin-binding proteins, has been shown to be associated with the regulation of synaptic plasticity. However, the role of LASP1 in the regulation of mood is still unclear...
Elorette, Catherine Aguilar, Brittany L Novak, Vera Forcelli, Patrick A Malkova, Ludise
Published in
Neuropharmacology
The amygdala is a key component of the neural circuits mediating the processing and response to emotionally salient stimuli. Amygdala lesions dysregulate social interactions, responses to fearful stimuli, and autonomic functions. In rodents, the basolateral and central nuclei of the amygdala have divergent roles in behavioral control. However, few ...
Camacho-Hernandez, Gisela Andrea Taylor, Palmer
Published in
Neuropharmacology
It has been almost 20 years since the discovery and crystallization of a structural surrogate, the Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP), comprising the extracellular domain of the nicotinic acetylcholine receptors (nAChRs). Structural characterization of this soluble protein has increased our understanding of the requirements ...
Hoyer, Daniel
Published in
Neuropharmacology
Targeting the serotonin (5-HT) system is no simple task: there are at least 15 5-HT receptors, in addition to a number of transporters and metabolizing enzymes. Multiple 5-HT receptor variants exist due to genetic variations and/or post translational modifications, splice variants or editing variants. Some receptors may form homo and heteromers. Th...
