Gordeeva, Olga Safandeev, Vitaliy
Published in
Neuropharmacology
Biogenic monoamines are involved in the regulation of various processes in both neural and non-neural cells during development. The present study aimed to identify the regulatory effects of serotonin (5-HT) and its precursors (l-tryptophan and 5-hydroxytryptophan, 5-HTP) on proliferation and cell death in mouse embryonic stem cells (ESCs) and embry...
Cisneros, I.E. Cunningham, K.A.
Published in
Neuropharmacology
The coronavirus disease 2019 (Covid-19) pandemic intensified the already catastrophic drug overdose and substance use disorder (SUD) epidemic, signaling a syndemic as social isolation, economic and mental health distress, and disrupted treatment services disproportionally impacted this vulnerable population. Along with these social and societal fac...
Dassati, Sarah Schweigreiter, Rüdiger Buechner, Susanne Waldner, Andreas
Published in
Neuropharmacology
Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder after Alzheimer's disease. Increasing evidence highlights the role of age-related chronic inflammation, oxidative stress and mitochondrial dysfunction in the pathogenesis of PD. A combination of these factors impairs the crosstalk between mitochondria and lyso...
Zhang, Bing Yang, Xili Ye, Luyu Liu, Rui Ye, Binglu Du, Weijia Shen, Fuyi Li, Qian Guo, Fan Liu, Jinqi
...
Published in
Neuropharmacology
The fast-onset antidepressant actions of ketamine at subanaesthetic doses have attracted enormous interest in psychiatric disease treatment. However, the severe psychotomimetic side effects foster an urgent need to deeply understand the fast-onset antidepressant mechanism of ketamine. Ketamine, as a non-competitive NMDAR antagonist, increases the o...
Srivastava, Anup K Choudhury, Subhasree Roy Karmakar, Surajit
Published in
Neuropharmacology
Epigenetic polycomb repressor complex-1 subunit BMI-1 plays a pivotal role in the process of gene repression to maintain the self-renewal and differentiation state of neurogenic tissues. Accumulating reports links lower expression of BMI-1 fails to regulate the repression of anti-oxidant response genes disrupt mitochondrial homeostasis underlying n...
McCool, Brian A
Published in
Neuropharmacology
This review highlights literature relating the anatomy, physiology, and behavioral contributions by projections between rodent prefrontal cortical areas and the basolateral amygdala. These projections are robustly modulated by both environmental experience and exposure to drugs of abuse including ethanol. Recent literature relating optogenetic and ...
Dunigan, Anna I Olson, David P Roseberry, Aaron G
Published in
Neuropharmacology
Increasing evidence indicates that the melanocortin and mesolimbic dopamine (DA) systems interact to regulate feeding and body weight. Because melanocortin-3 receptors (MC3R) are highly expressed in the ventral tegmental area (VTA), we tested whether VTA neurons expressing these receptors (VTA MC3R neurons) control feeding and body weight in vivo. ...
Luo, Yixiao Zhao, Penghui Dou, Mengxiao Mao, Jiawen Zhang, Ge Su, Yujiao Wang, Qingqun Wang, Qian Wang, Yurun Sun, Ruoxuan
...
Published in
Neuropharmacology
Increasing evidence indicates that gut microbiota and its metabolites can influence the brain function and the related behaviors. Trimethylamine N-oxide (TMAO), an indirect metabolite of gut microbiota, has been linked to aging, cognitive impairment, and many brain disorders. However, the potential effects of TMAO on social behaviors remain elusive...
Cheng, Yifeng Xie, Xueyi Lu, Jiayi Gangal, Himanshu Wang, Wei Melo, Sebastian Wang, Xuehua Jerger, Jared Woodson, Kayla Garr, Eric
...
Published in
Neuropharmacology
Uncontrolled drug-seeking and -taking behaviors are generally driven by maladaptive corticostriatal synaptic plasticity. The orbital frontal cortex (OFC) and its projections to the dorsomedial striatum (DMS) have been extensively implicated in drug-seeking and relapse behaviors. The influence of the synaptic plasticity of OFC projections to the DMS...
Bardo, Michael T Hammerslag, Lindsey R Malone, Samantha G
Published in
Neuropharmacology
Early life adversity can set the trajectory for later psychiatric disorders, including substance use disorders. There are a host of neurobiological factors that may play a role in the negative trajectory. The current review examines preclinical evidence suggesting that early life adversity specifically involving social factors (maternal separation,...
