Cheong, Rachel Y Baldo, Barbara Sajjad, Muhammad U Kirik, Deniz Petersén, Åsa
Published in
Neuropathology and applied neurobiology
Huntington disease (HD) is a fatal neurodegenerative disorder with no disease-modifying treatments approved so far. Ongoing clinical trials are attempting to reduce huntingtin (HTT) expression in the central nervous system (CNS) using different strategies. Yet, the distribution and timing of HTT-lowering therapies required for a beneficial clinical...
Kirschenbaum, Daniel Imbach, Lukas L Rushing, Elisabeth J Frauenknecht, Katrin B M Gascho, Dominic Ineichen, Benjamin V Keller, Emanuela Kohler, Sibylle Lichtblau, Mona Reimann, Regina R
...
Published in
Neuropathology and applied neurobiology
Coronavirus disease 19 (COVID-19) is a rapidly evolving pandemic caused by the coronavirus Sars-CoV-2. Clinically manifest central nervous system symptoms have been described in COVID-19 patients and could be the consequence of commonly associated vascular pathology, but the detailed neuropathological sequelae remain largely unknown. A total of six...
Smith, A R Wheildon, G Lunnon, K
Published in
Neuropathology and applied neurobiology
In late 2014, the first epigenome-wide association studies of DNA modifications in Alzheimer's disease brain samples were published. Over the last 5 years, further studies have been reported in the field and have highlighted consistent and robust alterations in DNA modifications in AD cortex. However, there are some caveats associated with the majo...
McAleese, K E Walker, L Erskine, D Johnson, M Koss, D Thomas, A J Attems, J
Published in
Neuropathology and applied neurobiology
Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is present in approximately 50% of Alzheimer's disease (AD) cases and is associated with accelerated cognitive decline. Studies indicate a potential synergistic relationship between LATE-NC and hyperphosphorylated tau. It is unknown if LATE-NC is an independent ...
Ferrer, I Andrés-Benito, P
Published in
Neuropathology and applied neurobiology
Most individuals with AD neuropathological changes have co-morbidities which have an impact on the integrity of the WM. This study analyses oligodendrocyte and myelin markers in the frontal WM in a series of AD cases without clinical or pathological co-morbidities. From a consecutive autopsy series, 206 cases had neuropathological changes of AD; am...
Mahady, Laura J He, Bin Malek-Ahmadi, Michael Mufson, Elliott J
Published in
Neuropathology and applied neurobiology
Although telomere length (TL) and telomere maintenance proteins (shelterins) are markers of cellular senescence and peripheral blood biomarkers of Alzheimer's disease (AD), little information is available on telomeric alterations during the prodromal stage (MCI) of AD. We investigated TL in the default mode network (DMN), which underlies episodic m...
Lee, Krit Lai, Hei Ming Soerensen, Maja Hoejvang Hui, Edward Sai-Kam Ma, Victor Wan-San Cho, William Chi-Shing Ho, Yuen-Shan Chang, Raymond Chuen-Chung
Published in
Neuropathology and applied neurobiology
A variety of tissue clearing techniques have been developed to render intact tissue transparent. For thicker samples, additional partial tissue delipidation is required before immersion into the final refractive index (RI)-matching solution, which alone is often inadequate to achieve full tissue transparency. However, it is difficult to determine a...
Braun, Yannick Filipski, Katharina Bernatz, Simon Baumgarten, Peter Roller, Bastian Zinke, Jenny Zeiner, Pia S Ilina, Elena Senft, Christian Ronellenfitsch, Michael W
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Published in
Neuropathology and applied neurobiology
Changes in metabolism are known to contribute to tumour phenotypes. If and how metabolic alterations in brain tumours contribute to patient outcome is still poorly understood. Epigenetics impact metabolism and mitochondrial function. The aim of this study is a characterisation of metabolic features in molecular subgroups of isocitrate dehydrogenase...
Jaunmuktane, Z Brandner, S
Published in
Neuropathology and applied neurobiology
The prototype of transmissible neurodegenerative proteinopathies is prion diseases, characterized by aggregation of abnormally folded conformers of the native prion protein. A wealth of mechanisms has been proposed to explain the conformational conversion from physiological protein into misfolded, pathological form, mode of toxicity, propagation fr...
Zimmer, T S Ciriminna, G Arena, A Anink, J J Korotkov, A Jansen, F E van Hecke, W Spliet, W G van Rijen, P C Baayen, J C
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Published in
Neuropathology and applied neurobiology
Oxidative stress is evident in resected epileptogenic brain tissue of patients with developmental brain malformations related to mammalian target of rapamycin activation: tuberous sclerosis complex (TSC) and focal cortical dysplasia type IIb (FCD IIb). Whether chronic activation of anti-oxidant pathways is beneficial or contributes to pathology is ...
