Varshney, Mukesh Kumar Yu, Nancy Yiu-Lin Katayama, Shintaro Li, Xin Liu, Tianyao Wu, Wan-Fu Töhönen, Virpi Krjutškov, Kaarel Kere, Juha Fan, Xiaotang
...
Published in
Neuroendocrinology
Background: Male estrogen receptor beta (ERβ) knockout (BERKO) mice display anxiety and aggression linked to, among others, altered serotonergic signaling in the basolateral amygdala and dorsal raphe, impaired cortical radial glia migration, and reduced GABAergic signaling. The effects on primary motor cortex (M1 cortex) and locomotor activity as a...
Rodríguez-Remírez, María del Puerto-Nevado, Laura Fernández-Aceñero, María Jesús Cruz-Ramos, Marlid García-García, Laura Solanes, Sonia Molina-Roldán, Elena García-Foncillas, Jesús Cebrián, Arancha
Published in
Neuroendocrinology
Background: Galectin-1 (Gal-1) plays major roles in cancer by modulating different processes leading to tumor development and progression. In the last years, it has been suggested as a promising target for anticancer therapy. Recently, aflibercept has shown high affinity for Gal-1. Here, we investigated how aflibercept could exert its antitumor act...
Aulinas, Anna Guarda, Francisco J. Yu, Elaine W. Haines, Melanie S. Asanza, Elisa Silva, Lisseth Tritos, Nicholas A. Verbalis, Joseph Miller, Karen K. Lawson, Elizabeth A.
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Published in
Neuroendocrinology
Introduction: Hypopituitary patients are at risk for bone loss. Hypothalamic-posterior pituitary hormones oxytocin and vasopressin are anabolic and catabolic, respectively, to the skeleton. Patients with hypopituitarism may be at risk for oxytocin deficiency. Whether oxytocin and/or vasopressin contribute to impaired bone homeostasis in hypopituita...
Chang, Rachel Hernandez, Jennifer Gastelum, Cassandra Guadagno, Kaitlyn Perez, Lynnea Wagner, Edward J.
Published in
Neuroendocrinology
Objective: We examined whether pituitary adenylate cyclase-activating polypeptide (PACAP) excites proopiomelanocortin (POMC) neurons via PAC1 receptor mediation and transient receptor potential cation (TRPC) channel activation. Methods: Electrophysiological recordings were done in slices from both intact male and ovariectomized (OVX) female PACAP-C...
Buchanan-Hughes, Amy Pashley, Alex Feuilly, Marion Marteau, Florence Pritchard, D. Mark Singh, Simron
Published in
Neuroendocrinology
Background: Carcinoid heart disease (CHD) can develop in patients with carcinoid syndrome (CS), itself caused by overproduction of hormones and other products from some neuroendocrine tumours. The most common hormone is serotonin, detected as high 5-hydroxyindoleacetic acid (5-HIAA). This systematic literature review summarises current literature o...
Hadoux, Julien Blanchard, Pierre Scoazec, Jean-Yves Burtin, Pascal Planchard, David Malka, David Berdelou, Amandine Boige, Valérie Duvillard, Pierre Leboulleux, Sophie
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Published in
Neuroendocrinology
Background: Cancer survivors have a 14% increased risk of developing a malignancy compared with the general population. Second radiation-induced malignancies with different histologies have been described in different organs. Based on individual observations, we hypothesized that neuroendocrine carcinoma (NEC) could arise in irradiated organs. Meth...
Rehbein, Elisa Hornung, Jonas Sundström Poromaa, Inger Derntl, Birgit
Published in
Neuroendocrinology
Traditionally sex hormones have been associated with reproductive and developmental processes only. Since the 1950s we know that hormones can have organizational effects on the developing brain and initiate hormonal transition periods such as puberty. However, recent evidence shows that sex hormones additionally structure the brain during important...
Merola, Elettra Zandee, Wouter de Mestier, Louis Klümpen, Heinz Josef Makulik, Karolina Geboes, Karen van Velthuysen, Marie Louise Couvelard, Anne Cros, Jérôme van Eeden, Susanne
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Published in
Neuroendocrinology
Background: The correct histopathological diagnosis of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) is crucial for treatment selection and prognostication. It is also very challenging due to limited experience in nonexpert centers. Revision of pathology is standard of care for most patients who are referred to NEN expert centers. Obje...
Sowithayasakul, Panjarat Boekhoff, Svenja Bison, Brigitte Müller, Hermann L.
Published in
Neuroendocrinology
Background: Data on female fertility, pregnancy, and outcome of offspring after childhood-onset craniopharyngioma (CP) are rare. Study Design: Observational study on pregnancy rate and offspring outcome in female CP patients recruited in KRANIOPHARYNGEOM 2000/2007 since 2000. Results: A total of 451 CP patients (223 female) have been recruited, and...
Barraud, Sara Delemer, Brigitte Poirsier-Violle, Céline Bouligand, Jérôme Mérol, Jean-Claude Grange, Florent Higel-Chaufour, Brigitte Decoudier, Bénédicte Zalzali, Mohamad Dwyer, Andrew A.
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Published in
Neuroendocrinology
Background: Two loci (CHD7 and SOX10) underlying Kallmann syndrome (KS) were discovered through clinical and genetic analysis of CHARGE and Waardenburg syndromes, conditions that include congenital anosmia caused by olfactory bulb (CA/OBs) defects and congenital hypogonadotropic hypogonadism (CHH). We hypothesized that other candidate genes for KS ...
