Nijssen, Kevin M R Mensink, Ronald P Joris, Peter J
Published in
Neuroendocrinology
Brain insulin resistance is an important hallmark of age-related conditions, including type 2 diabetes (T2D) and dementia. This systematic review summarized effects of cerebral blood flow (CBF) responses to intranasal insulin to assess brain insulin sensitivity in healthy and diseased populations. We also explored relationships between changes in b...
Bonaldo, Brigitta Gioiosa, Laura Panzica, GianCarlo Marraudino, Marilena
Published in
Neuroendocrinology
Maternal behavior depends on a multitude of factors, including the environmental ones, such as Endocrine Disrupting Chemicals (EDCs), which are increasingly attracting attention. Bisphenol A (BPA), an EDC present in plastic, is known to exert negative effects on maternal behavior. Bisphenol S (BPS), a BPA-substitute, seems to share some endocrine d...
Rewitz, Karina Stubkjær Grønbæk, Henning Tabaksblat, Elizaveta Mitkina Dahl Baunwall, Simon Mark Dam, Gitte
Published in
Neuroendocrinology
Introduction: The European Neuroendocrine Tumor Society (ENETS) reports variables of prognostic significance in bronchopulmonary neuroendocrine neoplasms (BP-NENs). The aim of this study was to investigate prognostic factors, recurrence-free survival (RFS), and overall survival (OS) for patients with typical carcinoid (TC), atypical carcinoid (AC),...
Underwood, Conor F. Burke, Peter G.R. Kumar, Natasha N. Goodchild, Ann K. McMullan, Simon Phillips, Jacqueline K. Hildreth, Cara M.
Published in
Neuroendocrinology
Introduction: Angiotensin (Ang) II signalling in the hypothalamic paraventricular nucleus (PVN) via Ang type-1a receptors (AT1R) regulates vasopressin release and sympathetic nerve activity – two effectors of blood pressure regulation. We determined the cellular expression and function of AT1R in the PVN of a rodent model of polycystic kidney disea...
Raj, Nitya Coffman, Kelley Le, Tiffany Do, Richard Kinh Gian Rafailov, Johnathan Choi, Ye Chou, Joanne F. Capanu, Marinela Dunphy, Mark Fox, Josef J.
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Published in
Neuroendocrinology
Introduction: Lutetium-177 (177Lu)-DOTATATE received FDA approval in 2018 to treat somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (NETs). Little data are available on response and outcomes for well-differentiated (WD) high-grade (HG) NETs treated with 177Lu-DOTATATE. Materials and Methods: Patients with WD HG NETs treat...
Chen, Xianlong Mo, Shengwei Zong, Liju Yu, Shuangni Lu, Zhaohui Chen, Jie
Published in
Neuroendocrinology
Introduction: The RNA N6-methyladenosine (m6A) regulators play a crucial role in tumorigenesis and could be indicators of prognosis and therapeutic targets in various cancers. However, the expression status and prognostic value of m6A regulators have not been studied in pancreatic neuroendocrine neoplasms (PanNENs). We aimed to investigate the expr...
Capdevila, Jaume Ducreux, Michel García Carbonero, Rocio Grande, Enrique Halfdanarson, Thorvardur Pavel, Marianne Tafuto, Salvatore Welin, Staffan Valentí, Vicente Salazar, Ramón
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Published in
Neuroendocrinology
In May 1982, the US Food and Drug Administration (FDA) approved the use of streptozotocin to treat pancreatic neuroendocrine tumors (panNETs). Thus, this year marks 40 years since that landmark date. This review of streptozotocin to treat panNETs is intended to commemorate this anniversary. A historical perspective of the chemical structure, pharma...
Gentiluomo, Manuel Capurso, Gabriele Morelli, Luca Ermini, Stefano Pasquali, Claudio Latiano, Anna Tavano, Francesca Greenhalf, William Milanetto, Anna Caterina Landi, Stefano
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Published in
Neuroendocrinology
Introduction: Telomere length (TL) is a potential indicator of cancer predisposition; however, the multitude of techniques used to measure it causes the results to be heterogeneous and, in some cases, controversial. In the last years, several studies adopted a strategy based on TL-associated genetic variants to generate a polygenic score, often ref...
Caykoylu, Ali Kabadayi Sahin, Esra Ugurlu, Mustafa
Published in
Neuroendocrinology
Thyroid hormones have an essential role in brain maturation and neuronal functioning. The comorbidity of thyroid disorders and several mental disturbances is frequently reported. We aimed to evaluate the literature on the potential relationship between thyroid disorders and obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS)...
Hollander-Cohen, Lian Meir, Inbar Shulman, Miriam Levavi-Sivan, Berta
Published in
Neuroendocrinology
Introduction: As in all vertebrates, reproduction in fish is regulated by gonadotrophin-releasing hormone (GnRH) control on gonadotrophic hormones (GtHs) activity. However, the neuroendocrine factors that promote GnRH and GtH activity are unknown. In Nile tilapia (Oreochromis niloticus), sexual activity and reproduction ability depend on social ran...
