Zhang, Yadi Deng, Yuzhen Yang, Xiaoxi Xue, Hongmei Lang, Yumiao
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Neurochemical research
S-nitrosylation (SNO) is a covalent post-translational oxidative modification. The reaction is the nitroso group (-NO) to a reactive cysteine thiol within a protein to form the SNO. In recent years, a variety of proteins in human body have been found to undergo thiol nitrosylation under specific conditions. Protein SNO, which is closely related to ...
Ortiz, Cindy Juliet Cristancho Damasio, Caio Miranda Pruccoli, Letizia Nadur, Nathália Fonseca de Azevedo, Luciana Luiza Guedes, Isabella Alvim Dardenne, Laurent Emmanuel Kümmerle, Arthur Eugen Tarozzi, Andrea Viegas, Claudio Jr
...
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Neurochemical research
A new series of ten multifunctional Cinnamoyl-N-acylhydrazone-donepezil hybrids was synthesized and evaluated as multifunctional ligands against neurodegenerative diseases. The molecular hybridization approach was based on the combination of 1-benzyl-4-piperidine fragment from the anti-Alzheimer AChE inhibitor donepezil (1) and the cinnamoyl subuni...
Wang, Wenlei Ji, Zhen Yuan, Chunyan Yang, Yanfang
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Neurochemical research
Mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) are implicated in cerebral ischemia reperfusion (I/R) injury process. In this study, after extraction and identification of human umbilical cord MSCs (HMCs)-derived EVs, I/R rat models were established and treated with HMC-EVs to measure pathological damage, apoptosis and inflammati...
Mao, Zuchao Huang, Ruizhen Xu, Jing Guo, Ruixian Wei, Xuhong
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Neurochemical research
Peripheral nerve injury often leads to neuropathic pain. In the present study, we assessed the role of liver x receptor alpha (LXRα), an oxysterol regulated nuclear transcription factor that promotes reverse cholesterol transport and alternative (M2) macrophage activation, in the development of neuropathic pain. We found that compared to WT mice, i...
Tillinger, Andrej Mravec, Boris
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Neurochemical research
The corticotropin-releasing hormone family of peptides is involved in regulating the neuroendocrine stress response. Also, the vagus nerve plays an important role in the transmission of immune system-related signals to brain structures, thereby orchestrating the neuroendocrine stress response. Therefore, we investigated gene expression of urocortin...
Ding, Yuanting Liu, Heng Cen, Mofei Tao, Yuxiang Lai, Chencen Tang, Zhi
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Neurochemical research
Alzheimer's disease (AD) and diabetes mellitus (DM) share common pathophysiological findings, in particular, the mammalian target of rapamycin (mTOR) has been strongly implied to link to AD, while it also plays a key role in the insulin signaling pathway. However, the mechanism of how DM and AD is coupled remains elusive. In the present study, we f...
Hong, Jiena Chen, Jiemei Li, Chao An, Delian Tang, Zhiming Wen, Hongmei
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Neurochemical research
Poststroke cognitive impairment (PSCI) is one of the most severe sequelae of stroke and lacks effective treatment. Previous studies have shown that high-frequency repetitive transcranial magnetic stimulation (rTMS) may be a promising PSCI therapeutic approach, but the underlying mechanism is unclear. To uncover the effect of rTMS on PSCI, a transie...
Fang, Jintao Li, Liang Zhai, Hong Qin, Bengang Quan, Daping Shi, Enxian Zhu, Menghai Yang, Jiantao Liu, Xiaolin Gu, Liqiang
...
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Neurochemical research
The C5-C6 nerve roots are usually spared from avulsion after brachial plexus injury (BPI) and can thus be used as donors for nerve repair. A BPI rat model with C5-C6 nerve root stumps has been established in our previous work. The aim of this study was to test whether riluzole loaded into a thermosensitive hydrogel could applied locally in the nerv...
Wang, Hongjun Li, Mingze Cui, Haibin Song, Xiangyuan Sha, Qian
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Neurochemical research
Retinoblastoma (RB) is a common intraocular malignant tumor. The growing evidence has reported that circular RNAs (circRNAs) play critical roles in RB development. Therefore, the purpose of the study is to investigate the regulatory mechanism of circDHDDS in RB. The real-time quantitative polymerase chain reaction (RT-qPCR) assay was used to quanti...
Wu, Po-Ming Lin, Chih-Hao Lee, Hsueh-Te Shih, Hsin-I Huang, Chao-Ching Tu, Yi-Fang
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Neurochemical research
Neonatal hypoxic-ischemic encephalopathy is the most common cause of neurological disability in infancy. Superimposed inflammation may further worsen neurological outcomes. Reliable biomarkers which are both sensitive to hypoxic-ischemia and inflammation are critically needed. We tested plasma osteopontin (OPN) and glial fibrillary astrocytic prote...