Ho, Christabel Fung-Yih Bon, Claire Poh-Ee Ng, Yee-Kong Herr, Deron R Wu, Jui-Sheng Lin, Teng-Nan Ong, Wei-Yi
Published in
Neurochemical research
The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation, hippocampo-prefrontal cortical long-term-potentiation, spatial working memory, and anti-nociception/anxiety. I...
Hui, Yang Chengyong, Tang Cheng, Luo Haixia, He Yuanda, Zhou Weihua, Yu
Published in
Neurochemical research
Oxidative stress and cytotoxic damage induced by amyloid beta (Aβ) have been considered pivotal in the pathogenesis of Alzheimer's disease (AD) and may represent a target for treatment. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway elicits a survival signal to protect against multiple injuries, and the transcription factor nuclear factor ery...
Deane, Catherine A S Brown, Ian R
Published in
Neurochemical research
Heat shock proteins are involved in cellular repair and protective mechanisms that counter characteristic features of neurodegenerative diseases such as protein misfolding and aggregation. The HSPA (Hsp70) multigene family includes the widely studied HSPA1A (Hsp70-1) and the little studied HSPA6 (Hsp70B') which is present in the human genome and no...
Xu, Zhi-Peng Gan, Guo-Sheng Liu, Yu-Min Xiao, Jin-Song Liu, Han-Xing Mei, Bin Zhang, Jun-Jian
Published in
Neurochemical research
Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that adiponectin supplements signific...
Guo, Dongdong Lu, Xingang Xu, Xiaoli Gou, Haixin Wang, Zhiqian Cao, Yi Luo, Xingjing
Published in
Neurochemical research
Vinorine is a monoterpenoid indole alkaloid, a type of natural alkaloids. Growing reports exhibited the numerous pharmacology activities of vinorine such as anti-inflammation, anti-bacterial and anti-tumor. In this study, the effect of vinorine injection (7.5, 15 and 30 mg/kg) on motor function, sensation and nerve regeneration in sciatic nerve cru...
Moriyama, Mitsuaki Fujitsuka, Shunsuke Kawabe, Kenji Takano, Katsura Nakamura, Yoichi
Published in
Neurochemical research
Zn2+ plays a crucial role in the CNS where it accumulates in synaptic vesicles and is released during neurotransmission. Synaptically released Zn2+ is taken up by neurons and astrocytes. The majority of previous work has focused on neuronal damage caused by excess Zn2+. However, its effect on astrocyte function is not well understood. We examined t...
Wang, Binbin Fan, Bingbing Dai, Qijun Xu, Xingguo Jiang, Peipei Zhu, Lin Dai, Haifeng Yao, Zhigang Xu, Zhongling Liu, Xiaojuan
...
Published in
Neurochemical research
Neuropathic pain is a complicated clinical syndrome caused by heterogeneous etiology. Despite the fact that the underlying mechanisms remain elusive, it is well accepted that neuroinflammation plays a critical role in the development of neuropathic pain. Fascin-1, an actin-bundling protein, has been proved to be involved in the processing of divers...
Sun, Qinru Jia, Ning Yang, Jie Chen, Guomin
Published in
Neurochemical research
Substantial evidence has shown that elevated circulating corticosteroids or chronic stress contributes to neuronal cell death, cognitive and mental disorders. However, the underlying mechanism is still unclear. Taurine is considered to protect neuronal cells from apoptotic cell death in neurodegenerative diseases and neuropsychiatric disorders. In ...
Pelsőczi, Péter Lévay, György
Published in
Neurochemical research
Automated homecage monitoring systems are now widely recognized and used tools in cognitive neuroscience. However, few of these studies cover pharmacological interventions. Scopolamine, an anticholinergic memory disrupting agent is frequently used to study learning behavior. We studied the impact of scopolamine treatment in a relevant dose-range on...
Huang, Haitao Liu, Huawei Yan, Rongzeng Hu, Min
Published in
Neurochemical research
The ERK/MAPK and PI3K/Akt signaling pathways play important role in neuronal survival and axonal regeneration after peripheral nerve injury. However, the relative importance and degree of functional overlap of the two pathways are still debated due to lack of in-vivo data. We used rats which underwent a facial nerve axotomy, and examined subsequent...
