Yang, Jiahua Du, Chenchen Li, Yinghui Liu, Rong Jing, Cuiting Xie, Junxia Wang, Jun
Published in
Neurochemical research
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of iron in the substantia nigra. While iron accumulation and inflammation are implicated in PD pathogenesis, their impact on oligodendrocytes, the brain's myelin-forming cells, remains elusive. This study investi...
Angst, Gabrielle Tang, Xin Wang, Chenran
Published in
Neurochemical research
Microglia are the residential immune cells of central nervous system and they are crucial for brain development and homeostasis, as well as the progression of inflammatory brain diseases. To study microglia's physiological and pathological functions, one of the most widely used models is primary microglia culture from neonatal rodents. However, pri...
Furube, Eriko Ohgidani, Masahiro Yoshida, Shigetaka
Published in
Neurochemical research
Axonal injury and demyelination occur in demyelinating diseases, such as multiple sclerosis, and the detachment of myelin from axons precedes its degradation. Paranodes are the areas at which each layer of the myelin sheath adheres tightly to axons. The destruction of nodal and paranodal structures during inflammation is an important pathophysiolog...
Lu, Zhengyang Shen, Haitao Li, Xiang Li, Haiying You, Wanchun Wang, Zhong Chen, Gang
Published in
Neurochemical research
Subarachnoid hemorrhage (SAH) is associated with circadian rhythm abnormalities, in which REV-ERBα plays a major regulatory role. Our ambition was to investigate the capacity of REV-ERBα to inhibit neuronal neuroapoptosis induced by early brain injury (EBI) after SAH. The endovascular perforation model was used to produce experimental SAH in Spragu...
Zhang, Hui Sun, Xiaoru Li, Jun Shan, Weiran Yang, Jianjun Zuo, Zhiyi
Published in
Neurochemical research
Surgery and anesthesia in neonates may lead to cognitive impairment or abnormal behaviors. It has been shown that autophagy plays a critical role in neuropsychiatric disorders, while the role of autophagy in postoperative cognitive impairment in neonates is not known. Here, we determined this role and the involvement of endoplasmic reticulum (ER) s...
Javanbakht, Parinaz Taghizadeh, Fatemeh Takabi, Fatemeh Shirani Tajik, Mohammadhassan Iranshahi, Saeideh Pasbakhsh, Parichehr Kashani, Iraj Ragerdi Mojaverrostami, Sina
Published in
Neurochemical research
It has been indicated that calorie restriction (CR) leads to several neuroprotective effects against physiological aging and different neurodegenerative disorders. Unfortunately, the definite therapeutic strategy is not introduced for Multiple sclerosis (MS) as an autoimmune disease of central nervous system (CNS) and researchers are striving to fi...
Zhang, Yang Jiang, Weiwei Sun, Wenjie Guo, Weiming Xia, Beibei Shen, Xiangru Fu, Mingyuan Wan, Teng Yuan, Mei
Published in
Neurochemical research
Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in the central nervous system and cardiovascular system, and is involved in the regulation of various physiopathological mechanisms such as apoptosis, neuroinflamm...
He, Liming Chang, Qiang Zhang, Yannan Guan, Xiaoming Ma, Zhuo Chen, Xu Liu, Wenbo Li, Yakun Feng, Haoyu
Published in
Neurochemical research
Central nervous injury and regeneration repair have always been a hot and difficult scientific questions in neuroscience, such as spinal cord injury (SCI) caused by a traffic accident, fall injury, and war. After SCI, astrocytes further migrate to the injured area and form dense glial scar through proliferation, which not only limits the infiltrati...
Zhou, Qi Zheng, Zilei Wang, Xupeng Li, Wei Wang, Luqi Yin, Chunping Zhang, Qi Wang, Qiujun
Published in
Neurochemical research
Postoperative cognitive dysfunction (POCD) is a common complication of central nervous system after anesthesia or surgery. Sevoflurane, an inhalation anesthetic, may inhibit cholinergic pathway that induce neuronal death and neuroinflammation, ultimately leading to POCD. Transauricular vagus nerve stimulation (taVNS) has neuroprotective effects in ...
Kong, Deping Tan, Rui Gao, Yongfeng Gao, Shan Feng, Zhaoyang Qi, Huibin Shen, Bowen Yang, Lili Shen, Xuri Jing, Xiuli
...
Published in
Neurochemical research
Arterial baroreflex (ABR) dysfunction has previously been associated with neuroinflammation, the most common pathological feature of neurological disorders. However, the mechanisms mediating ABR dysfunction-induced neuroinflammation are not fully understood. In the present study, we investigated the role of platelet CD40 ligand (CD40L) in neuroinfl...
