Jaumotte, Juliann D Franks, Alexis L Bargerstock, Erin M Kisanga, Edwina Philip Menden, Heather L Ghersi, Alexis Omar, Mahmoud Wang, Liping Rudine, Anthony Short, Kelly L
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Published in
Neurobiology of disease
Synthetic glucocorticoids (sGCs) such as dexamethasone (DEX), while used to mitigate inflammation and disease progression in premature infants with severe bronchopulmonary dysplasia (BPD), are also associated with significant adverse neurologic effects such as reductions in myelination and abnormalities in neuroanatomical development. Ciclesonide (...
Takahashi, Kazuhisa Mizukami, Hiroki Osonoi, Sho Ogasawara, Saori Hara, Yutaro Kudoh, Kazuhiro Takeuchi, Yuki Sasaki, Takanori Daimon, Makoto Yagihashi, Soroku
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Published in
Neurobiology of disease
Inflammation and oxidative stress contribute to the pathophysiology of diabetic neuropathy. According to recent evidence, the modulation of macrophage polarization in peripheral nerves represents a potential therapeutic target for diabetic neuropathy. Xanthine oxidase, which is a form of xanthin oxidoreductase, is the rate-limiting enzyme that cata...
Schinke, Christian Fernandez Vallone, Valeria Ivanov, Andranik Peng, Yangfan Körtvelyessy, Péter Nolte, Luca Huehnchen, Petra Beule, Dieter Stachelscheid, Harald Boehmerle, Wolfgang
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Published in
Neurobiology of disease
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent, potentially irreversible adverse effect of cytotoxic chemotherapy often leading to a reduction or discontinuation of treatment which negatively impacts patients' prognosis. To date, however, neither predictive biomarkers nor preventive treatments for CIPN are available, which is parti...
Pallos, Judit Jeng, Sophia McWeeney, Shannon Martin, Ian
Published in
Neurobiology of disease
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of late-onset Parkinson's disease. The pathogenic G2019S mutation enhances LRRK2 kinase activity and induces neurodegeneration in C. elegans, Drosophila and rodent models through unclear mechanisms. Gene expression profiling has the potential to provide detailed insigh...
Komirishetty, P Zubkow, K Areti, A Ong, H Zochodne, D W
Published in
Neurobiology of disease
While several new translational strategies to enhance regrowth of peripheral axons have been identified, combined approaches with different targets are rare. Moreover, few have been studied after a significant delay when growth programs are already well established and regeneration-related protein expression has waned. Here we study two approaches,...
Lee, Mijung Im, Wooseok Kim, Manho
Published in
Neurobiology of disease
Huntington's disease (HD) starts its pathology long before clinical manifestation, however, there is no therapy to cure it completely and only a few studies have been reported for delaying the progression of HD. Recently, it has been shown that heterochronic parabiosis can modulate the neurodegenerative diseases. Despite the importance of the trans...
Zhan, Jiangshan Fegg, Florian Nepomuk Kaddatz, Hannes Rühling, Sebastian Frenz, Julia Denecke, Bernd Amor, Sandra Ponsaerts, Peter Hochstrasser, Tanja Kipp, Markus
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Published in
Neurobiology of disease
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with episodes of inflammatory demyelination and remyelination. While remyelination has been linked with functional recovery in MS patients, there is evidence of ongoing tissue damage despite complete myelin repair. In this study, we investigated the long-t...
Yin, Zixiao Zhu, Guanyu Zhao, Baotian Bai, Yutong Jiang, Yin Neumann, Wolf-Julian Kühn, Andrea A Zhang, Jianguo
Published in
Neurobiology of disease
Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field potentials (LFPs), the electrophysiological population activity of neurons surrounding the depth electrode in the target area. With direct access to the subcortical activity, LFP research has provided valuable insight into disease mechanisms and cognitive process...
Har-Paz, Ilona Arieli, Elor Moran, Anan
Published in
Neurobiology of disease
The E4 allele of apolipoprotein E (apoE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). However, apoE4 may cause innate brain abnormalities before the appearance of AD-related neuropathology. Understanding these primary dysfunctions is vital for the early detection of AD and the development of therapeutic strategies....
Yang, Xiangjun Zeng, Qun Tezel, Gülgün
Published in
Neurobiology of disease
Retinal ganglion cells (RGCs) expanding from the retina to the brain are primary victims of neurodegeneration in glaucoma, a leading cause of blindness; however, the neighboring astroglia survive the glaucoma-related stress and promote neuroinflammation. In light of diverse functions of caspase-8 in apoptosis, cell survival, and inflammation, this ...
