Aman, Joshua E Johnson, Luke A Sanabria, David Escobar Wang, Jing Patriat, Remi Hill, Meghan Marshall, Ethan MacKinnon, Colum D Cooper, Scott E Schrock, Lauren E
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Published in
Neurobiology of disease
The goal of this study was to characterize the spectral characteristics and spatial topography of local field potential (LFP) activity in the internal segment of the globus pallidus (GPi) in patients with Parkinson's disease utilizing directional (segmented) deep brain stimulation (dDBS) leads. Data were collected from externalized dDBS leads of th...
Hsu, Simon Pimenova, Anna A Hayes, Kimberly Villa, Juan A Rosene, Matthew J Jere, Madhavi Goate, Alison M Karch, Celeste M
Published in
Neurobiology of disease
Alzheimer's disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline. More than 200 pathogenic mutations have been identified in amyloid-β precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2). Additionally, common and rare variants occur within APP, PSEN1, and PSEN2 that may be ...
Afghah, Zahra Chen, Xuesong Geiger, Jonathan D
Published in
Neurobiology of disease
Endosomes and lysosomes (endolysosomes) are membrane bounded organelles that play a key role in cell survival and cell death. These acidic intracellular organelles are the principal sites for intracellular hydrolytic activity required for the maintenance of cellular homeostasis. Endolysosomes are involved in the degradation of plasma membrane compo...
Kong, Geraldine Cao, Kim-Anh Lê Judd, Louise M Li, ShanShan Renoir, Thibault Hannan, Anthony J
Published in
Neurobiology of disease
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a trinucleotide repeat expansion in the huntingtin (HTT) gene, which is expressed ubiquitously throughout the brain and peripheral tissues. Whilst the focus of much research has been on the cognitive, psychiatric and motor symptoms of HD, the extent of peripheral pathol...
Severance, Emily G Yolken, Robert H
Published in
Neurobiology of disease
The body's microbiome represents an actively regulated network of novel mechanisms that potentially underlie the etiology and pathophysiology of a wide range of diseases. For complex brain disorders such as schizophrenia, understanding the cellular and molecular pathways that intersect the bidirectional gut-brain axis is anticipated to lead to new ...
Loreto, Andrea Hill, Ciaran S Hewitt, Victoria L Orsomando, Giuseppe Angeletti, Carlo Gilley, Jonathan Lucci, Cristiano Sanchez-Martinez, Alvaro Whitworth, Alexander J Conforti, Laura
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Published in
Neurobiology of disease
Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein SARM1. Manipulating the pathway through these proteins led to the identification of non-axotomy insults causing axon degeneration by a Wallerian-like mechanism, includin...
Jett, David A Spriggs, Shardell M
Published in
Neurobiology of disease
This special issue will describe cutting-edge translational research on the development of safe and effective therapeutics for treating exposure to toxic chemical threat agents that target the nervous system. These studies are supported by the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program. Chemica...
Chen, Zhichun Li, Guanglu Liu, Jun
Published in
Neurobiology of disease
Parkinson's disease (PD) is a neurodegenerative disease with a 200 year-long research history. Our understanding about its clinical phenotype and pathogenesis remains limited, although dopaminergic replacement therapy has significantly improved patient outcomes. Autonomic dysfunction is an essential category of non-motor phenotypes that has recentl...
Schuster, Jens Laan, Loora Klar, Joakim Jin, Zhe Huss, Mikael Korol, Sergiy Noraddin, Feria Hikmet Sobol, Maria Birnir, Bryndis Dahl, Niklas
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Published in
Neurobiology of disease
Dravet syndrome (DS) is an early onset refractory epilepsy typically caused by de novo heterozygous variants in SCN1A encoding the α-subunit of the neuronal sodium channel Nav1.1. The syndrome is characterized by age-related progression of seizures, cognitive decline and movement disorders. We hypothesized that the distinct neurodevelopmental featu...
Dutta, Debashis Kundu, Madhuchhanda Mondal, Susanta Roy, Avik Ruehl, Samantha Hall, Deborah A Pahan, Kalipada
Published in
Neurobiology of disease
Although Parkinson's disease (PD) is a progressive neurodegenerative disease, the disease does not progress or persist in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model, the most common animal model of PD. Recently, we have described that supplementation of regulated on activation, normal T cell expressed and secreted (RANTES), a c...
