Patterson, Joseph R Duffy, Megan F Kemp, Christopher J Howe, Jacob W Collier, Timothy J Stoll, Anna C Miller, Kathryn M Patel, Pooja Levine, Nathan Moore, Darren J
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Published in
Neurobiology of disease
Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system and motor deficits can be useful tools for Parkinson's disease (PD) research. The preformed fibril (PFF) synucleinopathy model in rodents generally displays these PD-relevant features, however,...
Mariani, Louise-Laure Longueville, Sophie Girault, Jean-Antoine Herve, Denis Gervasi, Nicolas
Parkinson's disease (PD) is characterized by severe locomotor deficits due to the disappearance of dopamine (DA) from the dorsal striatum. The development of PD symptoms and treatment-related complications such as dyskinesia have been proposed to result from complex alterations in intracellular signaling in both direct and indirect pathway striatal...
Lecca, Daniela Bader, Miaad Tweedie, David Hoffman, Alexander F Jung, Yoo Jin Hsueh, Shin-Chang Hoffer, Barry J Becker, Robert E Pick, Chaim G Lupica, Carl R
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Published in
Neurobiology of disease
Mild traumatic brain injury (mTBI) is a risk factor for neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). TBI-derived neuropathologies are promoted by inflammatory processes: chronic microgliosis and release of pro-inflammatory cytokines that further promote neuronal dysfunction and loss. Herein, we evaluat...
Regan, Samantha L Hufgard, Jillian R Pitzer, Emily M Sugimoto, Chiho Hu, Yueh-Chiang Williams, Michael T Vorhees, Charles V
Published in
Neurobiology of disease
Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized by inattention, impulsivity, and hyperactivity and is 75-90% heritable. Latrophilin-3 (LPHN3; or ADGRL(3)) is associated with a subtype of ADHD, but how it translates to symptoms is unknown. LPHN3 is a synaptic adhesion G protein coupled receptor that binds...
Shofty, Ben Bergmann, Eyal Zur, Gil Asleh, Jad Bosak, Noam Kavushansky, Alexandra Castellanos, F Xavier Ben-Sira, Liat Packer, Roger J Vezina, Gilbert L
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Published in
Neurobiology of disease
Children with the autosomal dominant single gene disorder, neurofibromatosis type 1 (NF1), display multiple structural and functional changes in the central nervous system, resulting in neuropsychological cognitive abnormalities. Here we assessed the pathological functional organization that may underlie the behavioral impairments in NF1 using rest...
Sunderhaus, Elizabeth R Law, Alexander D Kretzschmar, Doris
Published in
Neurobiology of disease
Swiss Cheese (SWS) is the Drosophila orthologue of Neuropathy Target Esterase (NTE), a phospholipase that when mutated has been shown to cause a spectrum of disorders in humans that range from intellectual disabilities to ataxia. Loss of SWS in Drosophila also causes locomotion deficits, age-dependent neurodegeneration, and an increase in lysophosp...
González, Oscar C Krishnan, Giri P Timofeev, Igor Bazhenov, Maxim
Published in
Neurobiology of disease
The biophysical mechanisms underlying epileptogenesis and the generation of seizures remain to be better understood. Among many factors triggering epileptogenesis are traumatic brain injury breaking normal synaptic homeostasis and genetic mutations disrupting ionic concentration homeostasis. Impairments in these mechanisms, as seen in various brain...
Essayan-Perez, Sofia Zhou, Bo Nabet, Amber M Wernig, Marius Huang, Yu-Wen Alvin
Published in
Neurobiology of disease
One in three people will develop Alzheimer's disease (AD) or another dementia and, despite intense research efforts, treatment options remain inadequate. Understanding the mechanisms of AD pathogenesis remains our principal hurdle to developing effective therapeutics to tackle this looming medical crisis. In light of recent discoveries from whole-g...
Ikonomidou, Chrysanthy Kirvassilis, George Swiney, Brant S Wang, Sophie H Huffman, Jacob N Williams, Sasha L Masuoka, Kobe Capuano, Saverio 3rd Brunner, Kevin R Crosno, Kristin
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Published in
Neurobiology of disease
Sedatives and anesthetics can injure the developing brain. They cause apoptosis of neurons and oligodendrocytes, impair synaptic plasticity, inhibit neurogenesis and trigger long-term neurocognitive deficits. The projected vulnerable period in humans extends from the third trimester of pregnancy to the third year of life. Despite all concerns, ther...
Russo, Isabella Kaganovich, Alice Ding, Jinhui Landeck, Natalie Mamais, Adamantios Varanita, Tatiana Biosa, Alice Tessari, Isabella Bubacco, Luigi Greggio, Elisa
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Published in
Neurobiology of disease
Several previous studies have linked the Parkinson's disease (PD) gene LRRK2 to the biology of microglia cells. However, the precise ways in which LRRK2 affects microglial function have not been fully resolved. Here, we used the RNA-Sequencing to obtain transcriptomic profiles of LRRK2 wild-type (WT) and knock-out (KO) microglia cells treated with ...
