Cheng, Hong Sheng Chong, Yuk Kien Lim, Eldeen Kai Yi Lee, Xin Yi Pang, Qing You Novera, Wisna Marvalim, Charlie Lee, Jeannie Xue Ting Ang, Beng Ti Tang, Carol
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Published in
Neuro-oncology
Precision treatment of glioblastoma is increasingly focused on molecular subtyping, with the mesenchymal subtype particularly resistant to temozolomide. Here, we aim to develop a targeted therapy for temozolomide resensitization in the mesenchymal subtype. We integrated kinomic profiles and kinase inhibitor screens from patient-derived proneural an...
Rozenblum, Laura Houillier, Caroline Baptiste, Amandine Soussain, Carole Edeline, Véronique Naggara, Philippe Soret, Marine Causse-Lemercier, Valérie Willems, Lise Choquet, Sylvain
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Published in
Neuro-oncology
The purpose of our study was to assess the predictive and prognostic role of 2-18F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/MRI during high-dose methotrexate-based chemotherapy (HD-MBC) in de novo primary central nervous system lymphoma (PCNSL) patients aged 60 and above. This prospective multicentric ancillary study includ...
Ke, Chao Huang, Boya Xiang, Jian Liang, Jinlian Wu, Guangjie Qiu, Minghui Cheng, Kai Mao, Lipeng Lei, Wen Hu, Yang
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Published in
Neuro-oncology
Meningioma is the most common primary intracranial tumor with a high frequency of postoperative recurrence, yet the biology of the meningioma malignancy process is still obscure. To identify potential therapeutic targets and tumor suppressors, we performed single-cell transcriptome analysis through meningioma malignancy, which included 18 samples s...
Hiller-Vallina, Sara Mondejar-Ruescas, Lucia Caamaño-Moreno, Marta Cómitre-Mariano, Blanca Alcivar-López, Denisse Sepulveda, Juan M Hernández-Laín, Aurelio Pérez-Núñez, Ángel Segura-Collar, Berta Gargini, Ricardo
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Published in
Neuro-oncology
Glioblastoma (GBM) is a highly malignant brain tumor that affects men more often than women. In addition, the former shows a poorer survival prognosis. To date, the reason for this sex-specific aggressiveness remains unclear. Therefore, the aim of this study is to investigate tumor processes that explain these sex differences. This was a retrospect...
Li, Bo Zhao, Shuang Li, Shouwei Li, Chunde Liu, Wei Li, Lin Cui, Bowen Liu, Xing Chen, Huiyuan Zhang, Jing
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Published in
Neuro-oncology
Intracranial germ cell tumors (IGCTs) are a rare group of malignancies that are clinically classified as germinomas and nongerminomatous germ cell tumors (NGGCTs). Previous studies have found that somatic mutations involving the mitogen-activated protein kinase/mTOR signaling pathway are common early events. However, a comprehensive genomic underst...
Galbraith, Kristyn Garcia, Mekka Wei, Siyu Chen, Anna Schroff, Chanel Serrano, Jonathan Pacione, Donato Placantonakis, Dimitris G William, Christopher M Faustin, Arline
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Published in
Neuro-oncology
Isocitrate dehydrogenase (IDH) mutant astrocytoma grading, until recently, has been entirely based on morphology. The 5th edition of the Central Nervous System World Health Organization (WHO) introduces CDKN2A/B homozygous deletion as a biomarker of grade 4. We sought to investigate the prognostic impact of DNA methylation-derived molecular biomark...
Dankner, Matthew Maritan, Sarah M Priego, Neibla Kruck, Georgia Nkili-Meyong, Andriniaina Nadaf, Javad Zhuang, Rebecca Annis, Matthew G Zuo, Dongmei Nowakowski, Alexander
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Published in
Neuro-oncology
Compared to minimally invasive brain metastases (MI BrM), highly invasive (HI) lesions form abundant contacts with cells in the peritumoral brain parenchyma and are associated with poor prognosis. Reactive astrocytes (RAs) labeled by phosphorylated STAT3 (pSTAT3) have recently emerged as a promising therapeutic target for BrM. Here, we explore whet...
Moon, Hye Hyeon Jeong, Jiheon Park, Ji Eun Kim, Namkug Choi, Changyong Kim, Young-Hoon Song, Sang Woo Hong, Chang-Ki Kim, Jeong Hoon Kim, Ho Sung
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Published in
Neuro-oncology
This study evaluated whether generative artificial intelligence (AI)-based augmentation (GAA) can provide diverse and realistic imaging phenotypes and improve deep learning-based classification of isocitrate dehydrogenase (IDH) type in glioma compared with neuroradiologists. For model development, 565 patients (346 IDH-wildtype, 219 IDH-mutant) wit...
Wang, Shaobo Qi, Yanhua Zhao, Rongrong Pan, Ziwen Li, Boyan Qiu, Wei Zhao, Shulin Guo, Xiaofan Ni, Shilei Li, Gang
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Published in
Neuro-oncology
Glioblastoma (GBM) is characterized by chromosome 7 copy number gains, notably 7q34, potentially contributing to therapeutic resistance, yet the underlying oncogenes have not been fully characterized. Pertinently, the significance of long noncoding RNAs (lncRNAs) in this context has gained attention, necessitating further exploration. FAM131B-AS2 w...
Dumot, Chloe Mantziaris, Georgios Dayawansa, Sam Peker, Selcuk Samanci, Yavuz Nabeel, Ahmed M Reda, Wael A Tawadros, Sameh R Abdelkarim, Khaled El-Shehaby, Amr M N
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Published in
Neuro-oncology
Stereotactic radiosurgery (SRS) is used to treat recurrent or residual nonfunctioning pituitary neuroendocrine tumors (NFPA). The objective of the study was to assess imaging and development of new pituitary hormone deficiency. Patients treated with single-session SRS for a NFPA were included in this retrospective, multicenter study. Tumor control ...
