Propagation of TDP-43 proteinopathy in neurodegenerative disorders.
Published in Neural regeneration research
Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling.
Published in Neural regeneration research
Much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous system. Axons in the central nervous system fail to regenerate, meaning that injuries or diseases that cause loss of axonal connectivity have life-changing consequences. In 2008, genetic deletion of PTEN was identif...
Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury.
Published in Neural regeneration research
The survival of microglia depends on the colony-stimulating factor-1 receptor (CSF1R) signaling pathway under physiological conditions. Ki20227 is a highly selective CSF1R inhibitor that has been shown to change the morphology of microglia. However, the effects of Ki20227 on the progression of ischemic stroke are unclear. In this study, male C57BL/...
11C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: a cross-section...
Published in Neural regeneration research
11C-PK11195 is a positron emitter tracer used for Positron Emission Tomography (PET) imaging of innate immune cell activation in studies of neuroinflammatory diseases. For the image quantitative analysis, it is necessary to quantify the intact fraction of this tracer in the arterial plasma during imaging acquisition (plasma intact fraction). Due to...
Neurovascular ageing: transcriptomic readout and implications on therapeutic targeting in Alzheimer's disease.
Published in Neural regeneration research
Rutin pretreatment promotes microglial M1 to M2 phenotype polarization.
Published in Neural regeneration research
Microglial cells are important resident innate immune components in the central nervous system that are often activated during neuroinflammation. Activated microglia can display one of two phenotypes, M1 or M2, which each play distinct roles in neuroinflammation. Rutin, a dietary flavonoid, exhibits protective effects against neuroinflammation. How...
Microglia activation: a role for mitochondrial DNA?
Published in Neural regeneration research
Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders....
Published in Neural regeneration research
Mesenchymal stem cells are multipotent cells that possess anti-inflammatory, anti-apoptotic and immunomodulatory properties. The effects of existing drugs for neurodegenerative disorders such as Alzheimer's disease are limited, thus mesenchymal stem cell therapy has been anticipated as a means of ameliorating neuronal dysfunction. Since mesenchymal...
Multiple sclerosis: why we should focus on both sides of the (auto)antibody.
Published in Neural regeneration research
Lithium beyond psychiatric indications: the reincarnation of a new old drug.
Published in Neural regeneration research
Lithium has been used in the treatment of bipolar disorders for decades, but the exact mechanisms of action remain elusive to this day. Recent evidence suggests that lithium is critically involved in a variety of signaling pathways affecting apoptosis, inflammation, and neurogenesis, all of which contributing to the complex pathophysiology of vario...
