Brain network correlates of epilepsy occurrence in multiple sclerosis and neuroinflammation.
Published in Neural regeneration research
New unexpected role for Wolfram Syndrome protein WFS1: a novel therapeutic target for Alzheimer's disease?
Published in Neural regeneration research
Can glial cells save neurons in epilepsy?
Published in Neural Regeneration Research
Epilepsy is a neurological disorder caused by the pathological hyper-synchronization of neuronal discharges. The fundamental research of epilepsy mechanisms and the targets of drug design options for its treatment have focused on neurons. However, approximately 30% of patients suffering from epilepsy show resistance to standard anti-epileptic chemo...
Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/v...
Published in Neural regeneration research
Inhibiting retinal neovascularization is the optimal strategy for the treatment of retina-related diseases, but there is currently no effective treatment for retinal neovascularization. P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) is a type of small non-coding RNA implicated in a variety of diseases. In this study, we found that th...
Neural progenitor cells derived from fibroblasts induced by small molecule compounds under hypoxia for treatment of Park...
...Published in Neural regeneration research
Neural progenitor cells (NPCs) capable of self-renewal and differentiation into neural cell lineages offer broad prospects for cell therapy for neurodegenerative diseases. However, cell therapy based on NPC transplantation is limited by the inability to acquire sufficient quantities of NPCs. Previous studies have found that a chemical cocktail of v...
The critical role of the endolysosomal system in cerebral ischemia.
Published in Neural regeneration research
Cerebral ischemia is a serious disease that triggers sequential pathological mechanisms, leading to significant morbidity and mortality. Although most studies to date have typically focused on the lysosome, a single organelle, current evidence supports that the function of lysosomes cannot be separated from that of the endolysosomal system as a who...
Ocular manifestations of central insulin resistance.
Published in Neural regeneration research
Central insulin resistance, the diminished cellular sensitivity to insulin in the brain, has been implicated in diabetes mellitus, Alzheimer's disease and other neurological disorders. However, whether and how central insulin resistance plays a role in the eye remains unclear. Here, we performed intracerebroventricular injection of S961, a potent a...
Anti-IgLON5 disease: a novel topic beyond neuroimmunology.
...Published in Neural regeneration research
Anti-IgLON5 disease is a recently defined autoimmune disorder of the nervous system associated with autoantibodies against IgLON5. Given its broad clinical spectrum and extremely complex pathogenesis, as well as difficulties in its early diagnosis and treatment, anti-IgLON5 disease has become the subject of considerable research attention in the fi...
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/A...
...Published in Neural regeneration research
Although many therapeutic interventions have shown promise in treating spinal cord injury, focusing on a single aspect of repair cannot achieve successful and functional regeneration in patients following spinal cord injury . In this study, we applied a combinatorial approach for treating spinal cord injury involving neuroprotection and rehabilitat...
Alterations in gut microbiota are related to metabolite profiles in spinal cord injury.
...Published in Neural regeneration research
Studies have shown that gut microbiota metabolites can enter the central nervous system via the blood-spinal cord barrier and cause neuroinflammation, thus constituting secondary injury after spinal cord injury. To investigate the correlation between gut microbiota and metabolites and the possible mechanism underlying the effects of gut microbiota ...
