Propagation of TDP-43 proteinopathy in neurodegenerative disorders.
Published in Neural regeneration research
Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling.
Published in Neural regeneration research
Much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous system. Axons in the central nervous system fail to regenerate, meaning that injuries or diseases that cause loss of axonal connectivity have life-changing consequences. In 2008, genetic deletion of PTEN was identif...
A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson’s disease: a brain radiomics study
...Published in Neural Regeneration Research
Brain radiomics can reflect the characteristics of brain pathophysiology. However, the value of T1-weighted images, quantitative susceptibility mapping, and R2* mapping in the diagnosis of Parkinson’s disease (PD) was underestimated in previous studies. In this prospective study to establish a model for PD diagnosis based on brain imaging informati...
Not only myelination: the immune-inflammatory functions of oligodendrocytes
Published in Neural Regeneration Research
The long-COVID-19 in older adults: facts and conjectures
Published in Neural Regeneration Research
Interleukin-4 promotes microglial polarization toward a neuroprotective phenotype after retinal ischemia/reperfusion inj...
Published in Neural Regeneration Research
Glaucoma results from irreversible loss of retinal ganglion cells (RGCs) through an unclear mechanism. Microglial polarization and neuroinflammation play an important role in retinal degeneration. Our study aimed to explore the function of microglial polarization during glaucoma progression and identify a strategy to alleviate retinal neuroinflamma...
Neuron-neuron attraction shapes morphology and activity of tissue engineered brain constructs
Published in Neural Regeneration Research
Riding the rails – different modes for RNA complex transport in axons
Published in Neural Regeneration Research
From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases
Published in Neural Regeneration Research
Two of the most common neurodegenerative disorders – Alzheimer’s and Parkinson’s diseases – are characterized by synaptic dysfunction and degeneration that culminate in neuronal loss due to abnormal protein accumulation. The intracellular aggregation of hyper-phosphorylated tau and the extracellular aggregation of amyloid beta plaques form the basi...
Unfolded p53 in non-neuronal cells supports bacterial etiology of Alzheimer’s disease
Published in Neural Regeneration Research
Alzheimer’s disease has proven to be largely intractable to treatment, despite years of research, and numerous trials of therapies that target the hallmarks of the disease – amyloid plaques and neurofibrillary tangles. The etiology of Alzheimer’s disease remains elusive. There is a growing body of evidence for an infectious trigger of Alzheimer’s d...
