Owrang, Marzieh Noorafshan, Ali Rafati, Ali Karbalay-Doust, Saied
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Exposure to stressors can cause functional disorders and structural damage to the stomach. Sertraline (SER) is an antidepressant and curcumin (CUR) is a natural compound with many properties. The current study aimed to investigate the impacts of stress, SER, and CUR on the stomach tissue using stereological methods. In total, 24 male and 24 female ...
Abouellil, Ahmed Bilal, Muhammad Taubert, Max Fuhr, Uwe
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Remdesivir is a direct-acting anti-viral agent. It was originally evaluated against filoviruses. However, during the COVID-19 pandemic, it was investigated due to its anti-viral activities against (SARS-CoV-2) virus. Therefore remdesivir received conditional approval for treatment of patients with severe coronavirus disease. Yet, its pharmacokineti...
Hattori, Yuichi Ishii, Kuniaki Yanai, Kazuhiko Endoh, Masao
Published in
Naunyn-Schmiedeberg's archives of pharmacology
The history of hitherto existing pharmacology in Japan presented here is authored in commemoration of the 150th anniversary of Naunyn-Schmiedeberg's Archives of Pharmacology. After the publication of the new book of anatomy "Anatomische Tabellen" translated into Japanese in 1774, the foundation of understanding the medical science was gradually for...
Afrouz, Mehdi Amani, Amin Eftekhari, Ali Coudret, Christophe Elias, Sabry G Ahmadian, Zainab Alebrahim, Mohammad Taghi
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Biocompatibility of nanoparticles is the most essential factor in their use in clinical applications. In this study, hyperbranched spermine (HS), hyperbranched spermine-polyethylene glycol-folic acid (HSPF), and hyperbranched spermine-polyethylene glycol-glucose (HSPG) were synthesized for DNA protection and gene delivery to breast cancer cells. Th...
Martínez-Razo, Gabriel Domínguez-López, María Lilia de la Rosa, José M Fabila-Bustos, Diego A Reyes-Maldonado, Elba Conde-Vázquez, Eliezer Vega-López, Armando
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Norcantharidin (NCTD) is the demethylated analog of cantharidin, with allegedly reduced toxicity. However, there is still limited information regarding its posology and potential risk in its use in cancer treatment. Healthy BDF1 mice were intraperitoneally administered with norcantharidin (0, 3, 6, 12, and 25 mg/kg) every 24 h for 6 days. Survivor ...
Philippu, Athineos Seifert, Roland
Published in
Naunyn-Schmiedeberg's archives of pharmacology
The purpose of this article is the historical survey of the foundation and development of pharmacology in Tartu (Dorpat), Estonia. Pharmacology was founded in Tartu by Naunyn, Buchheim, and Schmiedeberg. Genealogy and biographies including selected references of pharmacologists and pupils, who acted from the very beginning to today as directors of ...
Ono, Yasushi Sakamoto, Miho Makino, Kosho Tayama, Kuniaki Tada, Yukie Nakagawa, Yoshio Nakajima, Jun'ichi Suzuki, Jin Suzuki, Toshinari Takahashi, Hideyo
...
Published in
Naunyn-Schmiedeberg's archives of pharmacology
New synthetic opioids continue to emerge in the illicit market, and among them, fentanyl analogues pose a serious threat to the public health with their abuse and trafficking. We investigated the toxicity of fentanyl analogues on the liver and kidneys mediated by the µ-opioid receptor (MOR). Our study focused on 4-fluoro-isobutyrylfentanyl (4F-iBF)...
Le Marois, Marguerite Sanson, Camille Maizières, Magali-Anne Partiseti, Michel Bohme, G Andrees
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Clozapine is an atypical neuroleptic used to manage treatment-resistant schizophrenia which is known to inhibit cardiac hERG/KV11.1 potassium channels, a pharmacological property associated with increased risk of potentially fatal Torsades de Pointes (TdP) and sudden cardiac death (SCD). Yet, the long-standing clinical practice of clozapine does no...
Hattori, Yuichi Seifert, Roland
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Xia, Yuguo Tian, Ying Zhou, Dongqi Zhang, Lei Cai, Yichen Fu, Shunlian Zhang, Xiaoran Gao, Yang Chen, Qiu Gao, Ping
...
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Obesity is a well-established cause of reduced fertility and semen quality in men. Current evidence suggests that Sancai Lianmei granules (SCLM) effectively improve sexual function and semen quality in diabetic patients, while the gut microbiota can influence disease metabolism through various mechanisms. However, the effect of SCLM on the obesity-...
