Kayki-Mutlu, Gizem Aksoyalp, Zinnet Sevval Wojnowski, Leszek Michel, Martin C
Published in
Naunyn-Schmiedeberg's archives of pharmacology
The second year of the COVID-19 pandemic had no adverse effect on the number of new drug approvals by the US Food and Drug Administration (FDA). Quite the contrary, with a total of 50 new drugs, 2021 belongs to the most successful FDA years. We assign these new drugs to one of three levels of innovation: (1) first drug against a condition ("first-i...
Kotańska, Magdalena Knutelska, Joanna Nicosia, Noemi Mika, Kamil Szafarz, Małgorzata
Published in
Naunyn-Schmiedeberg's archives of pharmacology
The aim of this study was to determine, in the diet-induced obesity model in rats, the potential of Guanabenz to reduce body weight and ameliorate some metabolic disturbances. Obesity was induced in rats by a high-fat diet. After 10 weeks, rats were treated intraperitoneally with Guanabenz at the two doses: 2 or 5 mg/kg b.w./day, once daily for 25 ...
Prem, Priyanka N Sivakumar, Bhavana Boovarahan, Sri Rahavi Kurian, Gino A
Published in
Naunyn-Schmiedeberg's archives of pharmacology
The current study aims to determine the comparative efficacy of fisetin in reducing myocardial ischemia-reperfusion injury (IR) in isolated rat hearts when the drug was given either oral or intraperitoneal (ip) for short-term and long-term administration. Rats treated with fisetin (20 mg/kg-oral/ip) for short (30 min prior to surgery) and long (15 ...
Khezri, Mohammad Rafi Nazari-Khanamiri, Fereshteh Mohammadi, Tooba Moloodsouri, Donya Ghasemnejad-Berenji, Morteza
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected the world’s health systems for more than two years. This disease causes a high mortality rate followed by cytokine storm–induced oxidative stress and acute respiratory distress syndrome (ARDS). Therefore, many drugs have been co...
Hafner, Susanne Zolk, Oliver Barth, Holger
Published in
Naunyn-Schmiedeberg's archives of pharmacology
In medical studies, pharmacology is a subject with a high teaching and study load. The COVID-19 pandemic-related switch to distance learning implies challenges for students and teachers. To identify changes of behavior, attitudes, and needs among students and teachers in clinical pharmacology during the pandemic, regular surveys were conducted at U...
Hamimed, Selma Jabberi, Marwa Chatti, Abdelwaheb
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Over the last decade, nanotechnology has widely addressed many nanomaterials in the biomedical area with an opportunity to achieve better-targeted delivery, effective treatment, and an improved safety profile. Nanocarriers have the potential property to protect the active molecule during drug delivery. Depending on the employing nanosystem, the del...
Lim, Iris Chess-Williams, Russ
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
The β3-agonist mirabegron is thought to induce relaxation of the detrusor muscle, contributing to the improvement of overactive bladder symptoms. There has been recent interest in purposing mirabegron as a medical expulsive therapy drug to improve the passage of smaller kidney stones by relaxing the ureteral smooth muscles. The aim of this study wa...
Aygun, Hatice
Published in
Naunyn-Schmiedeberg's archives of pharmacology
COVID-19 is a highly contagious viral infection that has killed millions of people around the world. The most important diagnostic feature of COVID-19 is lymphocyte depletion, particularly the depletion of T cells. In COVID-19 infections, there is a link between destruction of T cells and increased expression of inhibitory immune checkpoint molecul...
Kehrenberg, Miriam C. A. Bachmann, Hagen S.
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Diuretics are drugs that increase the flow of urine. They are commonly used to treat edema, hypertension, and heart failure. Typically, the pharmacological group consists of five classes: thiazide diuretics, loop diuretics, potassium-sparing diuretics, osmotic diuretics, and carbonic anhydrase inhibitors. This traditional classification and the nom...
Lee, Jong Hoon
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
