Ibrahim, Kamilia M. Mantawy, Eman M. Elanany, Mona M. Abdelgawad, Hend S. Khalifa, Nuha M. Hussien, Rada H. El-Agroudy, Nermeen N. El-demerdash, Ebtehal
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
This study was performed to examine whether clindamycin could protect against doxorubicin (DOX)-induced acute nephrotoxicity, and if so, what molecular mechanisms responsible for this protective effect. Male albino rats were pretreated with clindamycin once per day for 5 consecutive days at a dose of 300 mg/kg, i.p, then received a single dose of D...
Schneider, Erich H.
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Bassiouni, Wesam Daabees, Tahia Norel, Xavier Senbel, Amira M.
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Various studies have confirmed that prostaglandins (PG) alter the bladder motor activity and micturition reflex in both human and animals. However, no sufficient data is reported about the effect of cyclooxygenase (COX) inhibitors neither in normal bladder physiology nor in pathological conditions. This study aims to compare the potential effects o...
Yang, Yufei Zhang, Lichao La, Xiaoqin Li, Zhuoyu Li, Hanqing Guo, Songjia
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Glucose-regulated protein 78 (GRP78) often highly expresses in a wide range of tumors, which plays promotive functions due to its diversity of location in the development of tumor. Particularly, GRP78 can be secreted into microenvironment by tumor cells through the pathway of exosome, which promotes proliferation, angiogenesis, and drug resistance ...
Chow, Louis W. C. Cheng, Ka-Shun Leong, Fai Cheung, Chi-Wai Shiao, Lian-Ru Leung, Yuk-Man Wong, Kar-Lok
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
ATP depletion induced by inhibiting glycolysis or mitochondrial ATP production has been demonstrated to cause cancer cell death. Whether ATP depletion can enhance the efficacy and potency of anti-cancer effects of herbal compounds is so far unknown. We examined the enhancing effect of ATP depletion on anti-cancer actions of tetrandrine (TET) in hum...
Viswanathan, S. Berlin Grace, V. M. Danisha, J. Perinba
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Targeting the specific molecular proteins or genes which are responsible for the suppression of cancer growth is currently an emerging molecular method to treat cancer. ATRA treatment is now considered as a molecular targeted therapy for many cancers. As ATRA exhibits its therapeutic effect through its receptors, this study was focused to investiga...
Rusli, Noradliyanti Amanah, Azimah Kaur, Gurjeet Adenan, Mohd Ilham Sulaiman, Shaida Fariza Wahab, Habibah Abdul Tan, Mei Lan
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Mitragynine is a major component isolated from Mitragyna speciosa Korth or kratom, a medicinal plant known for its opiate-like and euphoric properties. Multiple toxicity and fatal cases involving mitragynine or kratom have been reported but the underlying causes remain unclear. P-glycoprotein (P-gp) is a multidrug transporter which modulates the ph...
Schäfer, Julia Burhenne, Jürgen Weiss, Johanna Theile, Dirk
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Combining bortezomib with other anti-cancer drugs or glucocorticoids is more efficient in multiple myeloma than bortezomib alone. However, the molecular mechanism of this beneficial effect is largely unknown. To investigate the effects of these compounds on bortezomib’s anti-proliferative potency and its intracellular accumulation and potency to in...
Mizukami, Kazuhiko Yoshida, Hiroyuki Nozawa, Eisuke Wada, Koichi Ugawa, Tohru
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
Prostaglandins (PGs) are important lipid mediators of numerous physiologic and pathophysiologic processes in the kidney. PGE2, the most abundant renal PG, plays a major role in renal physiology, including renin release and glomerular hemodynamics. We investigated the renoprotective properties of the novel PGE2 EP4 receptor-selective antagonist ASP7...
Simpson, James Pálvölgyi, Adrienn Antoni, Ferenc A.
Published in
Naunyn-Schmiedeberg's Archives of Pharmacology
In mammals, nine genes encode trans-membrane adenylyl cyclase (tmAC) isoforms that synthesize the intracellular messenger compound cAMP from ATP. As cAMP is produced in virtually all types of cell, isoform-selective modulators of tmAC would have major research and therapeutic potential. This study investigated the effects of fungicide imidazoles pr...
