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A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a r...

Published in Nature medicine

Seasonal influenza viruses constantly change through antigenic drift and the emergence of pandemic influenza viruses through antigenic shift is unpredictable. Conventional influenza virus vaccines induce strain-specific neutralizing antibodies against the variable immunodominant globular head domain of the viral hemagglutinin protein. This necessit...