Baharom, Faezzah Ramirez-Valdez, Ramiro A. Tobin, Kennedy K. S. Yamane, Hidehiro Dutertre, Charles-Antoine Khalilnezhad, Ahad Reynoso, Glennys V. Coble, Vincent L. Lynn, Geoffrey M. Mulè, Matthew P.
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Published in
Nature Immunology
Seder and colleagues use a self-assembling nanoparticle vaccine and adjuvant to expand stem-like CD8+ T cells and trigger potent antitumor responses.
Netea, Mihai G Balkwill, Frances Chonchol, Michel Cominelli, Fabio Donath, Marc Y Giamarellos-Bourboulis, Evangelos J Golenbock, Douglas Gresnigt, Mark S Heneka, Michael T Hoffman, Hal M
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Published in
Nature immunology
A Correction to this paper has been published: https://doi.org/10.1038/ni.3790.
Gounari, Fotini
Published in
Nature Immunology
The natural variability of CRELD1 expression identified in comprehensive data sets from healthy individuals helps predict and establish its role in regulating T cell homeostasis.
Farris, A. Darise Guthridge, Joel M.
Published in
Nature Immunology
An exaggerated extrafollicular B cell response characteristic of active systemic lupus erythematosus also characterizes the B cell response to SARS-CoV-2 in those with severe COVID-19.
Grassmann, Simon Mihatsch, Lorenz Mir, Jonas Kazeroonian, Atefeh Rahimi, Roza Flommersfeld, Sophie Schober, Kilian Hensel, Inge Leube, Justin Pachmayr, Ludwig O.
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Published in
Nature Immunology
T cell memory formation is often described as occurring during the chronic phases of infection. Buchholz and colleagues use the phenomenon of ‘memory inflation’ following cytomegalovirus infection to show that a tiny subset of self-renewing T cells branch off early from the bulk population to generate memory.
Soumelis, Vassili Liu, Yong-Jun
Published in
Nature Immunology
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Bonaguro, Lorenzo Köhne, Maren Schmidleithner, Lisa Schulte-Schrepping, Jonas Warnat-Herresthal, Stefanie Horne, Arik Kern, Paul Günther, Patrick ter Horst, Rob Jaeger, Martin
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Published in
Nature Immunology
Within a human cohort, wide variation can occur with constitutively expressed proteins. Aschenbrenner and colleagues found that individuals with lower CRELD1 expression have decreased frequencies of naive CD4+ T cells. Mice with conditional Creld1 deficiency also exhibit a phenotype associated with immunological aging.
Soon, Megan S. F. Lee, Hyun Jae Engel, Jessica A. Straube, Jasmin Thomas, Bryce S. Pernold, Clara P. S. Clarke, Lachlan S. Laohamonthonkul, Pawat Haldar, Rohit N. Williams, Cameron G.
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Published in
Nature Immunology
CD4+ T cells are critical for effective responses to infection with the malaria parasite. Haque and colleagues use single-cell RNA sequencing and computational modeling to track T cell memory development during experimental Plasmodium infection of mice.
Galletti, Giovanni De Simone, Gabriele Mazza, Emilia M. C. Puccio, Simone Mezzanotte, Claudia Bi, Timothy M. Davydov, Alexey N. Metsger, Maria Scamardella, Eloise Alvisi, Giorgia
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Published in
Nature Immunology
The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells—one giving rise to a functional lineage, the other to an exhausted-like one.
Amann-Zalcenstein, Daniela Tian, Luyi Schreuder, Jaring Tomei, Sara Lin, Dawn S. Fairfax, Kirsten A. Bolden, Jessica E. McKenzie, Mark D. Jarratt, Andrew Hilton, Adrienne
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Published in
Nature Immunology
Exploring transcriptional heterogeneity of cKit+Sca1+ HSPCs using single cell RNA-sequencing, Naik and colleagues identify a population termed ‘lymphoid primed progenitors’ as the earliest stage of lymphoid lineage commitment, marked by downregulation of the stem/myeloid transcription factor Dach1.