Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis
Published in Nature Reviews Rheumatology
The term refractory rheumatoid arthritis (RA) implies treatment-resistant persistent joint and/or systemic inflammation; however, it is often used interchangeably with broader definitions such as ‘difficult to treat’ RA. Refractory RA could be stratified into two major categories; persistent inflammatory refractory RA (PIRRA), in which unabated inf...
