Published in Nature Neuroscience
This paper introduces ‘prospective configuration’, a new principle for learning in neural networks, which differs from backpropagation and is more efficient in learning and more consistent with data on neural activity and behavior.
Published in Nature neuroscience
Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP-AMP synthase (cGAS) diminishes cognitive resilience by decreasing the neuronal transcriptional network of myocyte enhancer factor 2c (MEF2C) th...
Published in Nature Neuroscience
In this study, Petrucco, Lavian et al. identify a circuit in the hindbrain of larval zebrafish that persistently encodes heading direction. Neurons of this network, of stereotypical morphology, inhibit each other to support ring attractor dynamics.
Published in Nature neuroscience
Knowing one's own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons (ANs) in the motor system that project to the brain are well positioned to provide such behavioral state signals. However, what ANs encode and where they convey these signals...
Published in Nature Neuroscience
The authors develop a reward optimization framework to study sustained deliberation in nonhuman primates. As the computational complexity increased, animals deliberated longer and applied more complex reasoning strategies to optimize rewards.
The spatiotemporal regulation of cell fate specification in the human developing spinal cord remains largely unknown. In this study, by performing integrated analysis of single-cell and spatial multi-omics data, we used 16 prenatal human samples to create a comprehensive developmental cell atlas of the spinal cord during post-conceptional weeks 5–1...
Published in Nature Neuroscience
Can erasing bad memories relieve pain? Stegemann et al. uncover the cellular basis of fear–pain interactions, reporting that fear potentiates pain via memories encoded in prefrontal engrams. Blocking these memory traces reduces chronic pain in mice.
Published in Nature Neuroscience
The authors find that the hippocampus creates a spatial and predictive cognitive map, and show how orbitofrontal and hippocampal computations select these maps adaptively to guide novel choices.
Published in Nature neuroscience
Recognizing sounds implicates the cerebral transformation of input waveforms into semantic representations. Although past research identified the superior temporal gyrus (STG) as a crucial cortical region, the computational fingerprint of these cerebral transformations remains poorly characterized. Here, we exploit a model comparison framework and ...
Published in Nature neuroscience
Cortical state, defined by population-level neuronal activity patterns, determines sensory perception. While arousal-associated neuromodulators-including norepinephrine (NE)-reduce cortical synchrony, how the cortex resynchronizes remains unknown. Furthermore, general mechanisms regulating cortical synchrony in the wake state are poorly understood....
