Published in Nature Cell Biology
Legube and Marnef review the association between R-loops and DNA repair. They discuss how R-loops are formed near DNA double-strand breaks (DSBs) and how R-loops affect transcription near DSBs and DSB repair processes.
Published in Nature Cell Biology
Using gastruloids and human embryos, Yang et al. demonstrate that aneuploid embryos can still lead to healthy births due to elimination of aneuploid cells by apoptosis in a BMP4-dependent manner.
Published in Nature Cell Biology
Monserrat et al. report that MSL inactivation suppresses tumour maintenance via enhancing chromosomal instability (CIN). Mechanistically, H4K16ac loss upon MSL inactivation generates under-replicated DNA, leading to CIN.
Published in Nature Cell Biology
Chromosomal instability (CIN) is a hallmark of malignant evolution that underpins cancer progression and therapeutic evasion. There are few established experimental systems to study CIN and ultimately develop potential therapeutic options. A new study now identifies the MSL chromatin complex as a potential vulnerability against CIN in cancer cells....
Published in Nature Cell Biology
Weijts et al. present a model of vasculogenesis in zebrafish whereby endothelial cells form a network of struts, allowing de novo formation of large-diameter blood vessels without a vascular cord or hollowing step.
Published in Nature Cell Biology
Yu et al. identify that STING bicondensates occur in virus-infected cells, thereby restricting TBK1 activation and innate immunity.
Published in Nature Cell Biology
The conserved chromatin remodeller DECREASED IN DNA METHYLATION 1 (DDM1) has long been an enigma given its powerful but likely indirect effect in maintaining plant DNA methylation. In this issue of Nature Cell Biology, Osakabe et al. show that the direct action of DDM1 is deposition of the H2A.W histone variant to silence transposable elements.
Published in Nature Cell Biology
STING is a key player in the IFN response to cytosolic DNA, and its multimerization is commonly associated with activation of the pathway. A new study now shows that STING forms ‘puzzle’-like condensates to limit the IFN response and constrain antiviral immune activation.
Published in Nature Cell Biology
Osakabe et al. report that the chromatin remodeler DDM1 silences transposable elements by mediating H2A.W deposition in Arabidopsis.
Published in Nature Cell Biology
Phase separation promotes clathrin-mediated endocytosis; Day et al. show that Eps15 and Fcho1 rely on weak, liquid-like interactions to efficiently catalyse endocytosis.
