Published in Nature Cell Biology
Clairmont et al. find that the TRIP13 ATPase regulates REV7–Shieldin dissociation to promote homology-directed repair and suppress non-homologous end joining, and show the importance of PARPi resistance in BRCA1-deficient cancers.
Published in Nature Cell Biology
Wang, Yu, Zhou, Song et al. profile cardiomyocytes and neighbouring cells from healthy adults and patients with heart failure and in recovery, and delineate their cellular compositions and interaction networks.
Published in Nature Cell Biology
The molecular clock regulates the rhythmic transcription of myriad genes, leading to a circadian pattern of expression of the encoded proteins. A study demonstrates circadian regulation of expression of components of the protein secretory pathway, providing a mechanism to generate circadian patterns of secreted protein expression.
Published in Nature Cell Biology
Motazedian et al. examine human T-cell genesis in haematopoietic organoids and show that RAG1 marks multipotent T-cell progenitors that arise directly from the haemogenic endothelium.
Published in Nature Cell Biology
Here, Chang et al. show that the circadian clock regulates secretion resulting in nocturnal procollagen synthesis and daytime collagen fibril assembly in mice to maintain the homeostasis of the collagen network.
Published in Nature Cell Biology
In this Review, Batsivari et al. discuss how cells in the bone marrow respond to inflammation, infection, leukaemia and chemotherapy.
Published in Nature Cell Biology
Gritsenko et al. identify p120-catenin as a modulator of neurogenesis and cell cycle pathways, thereby dictating cell–cell communication between glioma cells and regulating collective networks.
Published in Nature Cell Biology
Yahara et al. show that yolk-sac macrophages, which are derived from erythromyeloid progenitors, produce neonatal osteoclasts that support bone homeostasis and repair and also provide long-lasting osteoclasts in adult bone.
Published in Nature Cell Biology
Different types of stromal cells in the bone marrow associate to form niches that support differentiating blood cells and ensure lifelong production of all major blood lineages. A study now combines single-cell and spatial transcriptomics with imaging to infer the cellular composition and spatial architecture of specific niches.
Published in Nature Cell Biology
Tangential expansion of neural stem cells in the mammalian neocortex increases the number of cortical columns. A new study shows that neural stem cells that become detached from the apical surface during division regenerate an apical endfoot to ensure tangential expansion in the early stage but later lose this ability when radial expansion occurs.
