Published in Nature
The effect of cities on urban climate (often warmer but sometimes cooler than their surroundings) is largely explained by local hydroclimate and patterns of city development.
Published in Nature
Published in Nature
Parkinson’s disease (PD) is the most common movement disorder, with resting tremor, rigidity, bradykinesia and postural instability being major symptoms ( 1 ). Neuropathologically, it is characterised by the presence of abundant filamentous inclusions of α-synuclein in the form of Lewy bodies and Lewy neurites in some brain cells, including dopamin...
Published in Nature
The potential of mitigation actions to limit global warming within 2 °C (ref. 1) might rely on the abundant supply of biomass for large-scale bioenergy with carbon capture and storage (BECCS) that is assumed to scale up markedly in the future2-5. However, the detrimental effects of climate change on crop yields may reduce the capacity of BECCS and ...
Published in Nature
The perception of fat evokes strong appetitive and consummatory responses1. Here we show that fat stimuli can induce behavioural attraction even in the absence of a functional taste system2,3. We demonstrate that fat acts post-ingestively via the gut-brain axis to drive preference for fat. Using single-cell data, we identified the vagal neurons res...
Published in Nature
Published in Nature
Folates are essential nutrients with important roles as cofactors in one-carbon transfer reactions, being heavily utilized in the synthesis of nucleic acids and the metabolism of amino acids during cell division1,2. Mammals lack de novo folate synthesis pathways and thus rely on folate uptake from the extracellular milieu3. The human reduced folate...
Published in Nature
Optical atomic clocks are our most precise tools to measure time and frequency1-3. Precision frequency comparisons between clocks in separate locations enable one to probe the space-time variation of fundamental constants4,5 and the properties of dark matter6,7, to perform geodesy8-10 and to evaluate systematic clock shifts. Measurements on indepen...
Published in Nature
Cytoplasmic dynein is a microtubule motor that is activated by its cofactor dynactin and a coiled-coil cargo adaptor1-3. Up to two dynein dimers can be recruited per dynactin, and interactions between them affect their combined motile behaviour4-6. Different coiled-coil adaptors are linked to different cargos7,8, and some share motifs known to cont...
Published in Nature
