Eitan, Erez Hutchison, Emmette R Marosi, Krisztina Comotto, James Mustapic, Maja Nigam, Saket M Suire, Caitlin Maharana, Chinmoyee Jicha, Gregory A Liu, Dong
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Published in
NPJ aging and mechanisms of disease
Alzheimer's Disease (AD) is an age-related neurodegenerative disorder in which aggregation-prone neurotoxic amyloid β-peptide (Aβ) accumulates in the brain. Extracellular vesicles (EVs) are small 50-150 nanometer membrane vesicles that have recently been implicated in the prion-like spread of self-aggregating proteins. Here we report that EVs isola...
Kaya, Alaattin Ma, Siming Wasko, Brian Lee, Mitchell Kaeberlein, Matt Gladyshev, Vadim N
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NPJ aging and mechanisms of disease
The budding yeast has served as a useful model organism in aging studies, leading to the identification of genetic determinants of longevity, many of which are conserved in higher eukaryotes. However, factors that promote longevity in laboratory setting often have severe fitness disadvantage in the wild. Here, to obtain an unbiased view on longevit...
Bečanović, Kristina Muhammad, Asghar Gadawska, Izabella Sachdeva, Shiny Walker, David Lazarowski, Eduardo. R. Franciosi, Sonia Park, Kevin H. J. Côté, Hélène C. F. Leavitt, Blair R.
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npj Aging and Mechanisms of Disease
Mitochondrial dysfunction and bioenergetics failure are common pathological hallmarks in Huntington’s disease (HD) and aging. In the present study, we used the YAC128 murine model of HD to examine the effects of mutant huntingtin on mitochondrial parameters related to aging in brain and skeletal muscle. We have conducted a cross-sectional natural h...
Zong, Le Tanaka-Yano, Mayuri Park, Bongsoo Yanai, Hagai Turhan, Ferda T. Croteau, Deborah L. Tian, Jane Fang, Evandro F. Bohr, Vilhelm A. Beerman, Isabel
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npj Aging and Mechanisms of Disease
NAD+ supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD+ to physiological levels has been shown to improve the function of some adult stem cells, with implications that these changes will lead to sustained improvement of the tissue or system. Here, w...
Yu, Chih-Chieh Chang, Ferng-Chang Hong, Yong-Huei Li, Jian-Chiuan Chen, Po-Lin Chen, Chun-Hong Chiu, Tzai-Wen Lu, Tsai-Te Wang, Yun-Ming Kao, Chih-Fei
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npj Aging and Mechanisms of Disease
Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay, which is a simple sensory–motor task, to determine the cogn...
Banerjee, Subhashis Ghoshal, Sarbani Girardet, Clemence DeMars, Kelly M. Yang, Changjun Niehoff, Michael L. Nguyen, Andrew D. Jayanth, Prerana Hoelscher, Brittany A. Xu, Fenglian
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npj Aging and Mechanisms of Disease
The neural functions of adropin, a secreted peptide highly expressed in the brain, have not been investigated. In humans, adropin is highly expressed in astrocytes and peaks during critical postnatal periods of brain development. Gene enrichment analysis of transcripts correlating with adropin expression suggests processes relevant to aging-related...
Vanhunsel, Sophie Bergmans, Steven Beckers, An Etienne, Isabelle Van houcke, Jolien Seuntjens, Eve Arckens, Lut De Groef, Lies Moons, Lieve
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npj Aging and Mechanisms of Disease
Worldwide, people are getting older, and this prolonged lifespan unfortunately also results in an increased prevalence of age-related neurodegenerative diseases, contributing to a diminished life quality of elderly. Age-associated neuropathies typically include diseases leading to dementia (Alzheimer’s and Parkinson’s disease), as well as eye disea...
Shaker, Mohammed R. Aguado, Julio Chaggar, Harman Kaur Wolvetang, Ernst J.
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npj Aging and Mechanisms of Disease
Aging is a major risk factor for many neurodegenerative diseases. Klotho (KL) is a glycosylated transmembrane protein that is expressed in the choroid plexus and neurons of the brain. KL exerts potent anti-aging effects on multiple cell types in the body but its role in human brain cells remains largely unclear. Here we show that human cortical neu...
Komura, Tomomi Yamanaka, Mikihiro Nishimura, Kohji Hara, Keita Nishikawa, Yoshikazu
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npj Aging and Mechanisms of Disease
To assess the utility of autofluorescence as a noninvasive biomarker of senescence in Caenorhabditis elegans, we measured the autofluorescence of individual nematodes using spectrofluorometry. The fluorescence of each worm increased with age. Animals with lower fluorescence intensity exhibited longer life expectancy. When proteins extracted from wo...
Holzscheck, Nicholas Falckenhayn, Cassandra Söhle, Jörn Kristof, Boris Siegner, Ralf Werner, André Schössow, Janka Jürgens, Clemens Völzke, Henry Wenck, Horst
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npj Aging and Mechanisms of Disease
The development of ‘age clocks’, machine learning models predicting age from biological data, has been a major milestone in the search for reliable markers of biological age and has since become an invaluable tool in aging research. However, beyond their unquestionable utility, current clocks offer little insight into the molecular biological proce...