Schwarz, Benjamin Friedl, Anna A Girst, Stefanie Dollinger, Günther Reindl, Judith
Published in
Mutation research
The accumulation and spatial distribution of 53BP1, BRCA1 and Rad51, key proteins in DNA double-strand break (DSB) repair, was investigated with high temporal resolution over a time span of 24 h, using STED nanoscopy. DNA lesions were induced by irradiation with high-LET (linear energy transfer) α-particles. We show that 53BP1 IRIF formation occurs...
Mamur, Sevcan Yuzbasioglu, Deniz Altok, Kadriye Unal, Fatma Deger, Serpil Muge
Published in
Mutation research
Chronic kidney disease (CKD) is a common health problem. The primary etiology of CKD is diabetes mellitus (DM). The aim of our study is to determine the possible role of DM and also effects of other factors such as hypertension, duration of hemodialysis (HD), age, sex, body mass index (BMI), and levels of hemoglobin (HB), intact parathormone (iPTH)...
Cox, Julie A White, Paul A
Published in
Mutation research
The mutagenicity of Direct Black 38, Sudan I, and Para Red were evaluated in the in vivo MutaMouse assay and the in vitro MutaMouse primary hepatocyte (PH) assay. Direct Black 38 is an International Agency for Research on Cancer (IARC) Group 1 carcinogen and a prototypical benzidine-based azo compound that requires azo-reduction to yield a DNA-reac...
Dutta, Susmita Bahadur, Min
Published in
Mutation research
To assess possible genotoxic effects of pesticide exposure in occupationally exposed tea-garden workers, DNA damage in peripheral blood lymphocytes was evaluated with the comet assay. The effects of smoking and alcohol consumption were also examined. The comet tail length, % tail DNA, and Olive tail moment were significantly higher in pesticide-exp...
Královec, Karel Havelek, Radim Kročová, Eliška Kučírková, Lucie Hauschke, Martina Bartáček, Jan Palarčík, Jiří Sedlák, Miloš
Published in
Mutation research
Iron oxide nanoparticles (IONPs) have a great potential with regard to cell labelling, cell tracking, cell separation, magnetic resonance imaging, magnetic hyperthermia, targeted drug and gene delivery. However, a growing body of research has raised concerns about the possible unwanted adverse cytotoxic effects of IONPs. In the present study, the i...
Visweswaran, Shangamithra Joseph, Santhosh S, Vinay Hegde O, Annalakshmi Jose, M T Perumal, Venkatachalam
Published in
Mutation research
Interventional radiology-based imaging is the preferred choice for diagnosis and therapy of many complex diseases, despite possible adverse effects of the radiation exposures. We have measured induced DNA damage and changes in gene expression in relation to entrance surface dose (ESD) in peripheral blood samples of patients (n = 51) who underwent n...
Kobets, Tetyana Duan, Jian-Dong Brunnemann, Klaus D Vock, Esther Deschl, Ulrich Williams, Gary M
Published in
Mutation research
DNA-damaging activities of twenty-four structurally diverse unsubstituted and substituted cyclic compounds were assessed in embryo-fetal chicken livers. Formation of DNA adducts and strand breaks were measured using the nucleotide 32P-postlabelling (NPL) and comet assays, respectively. Unsubstituted monocyclic benzene, polycyclic fused ring compoun...
Okada, Emiko Fujiishi, Yohei Narumi, Kazunori Kado, Shoichi Ohyama, Wakako
Published in
Mutation research
The usefulness of the rat repeated-dose liver and gastrointestinal (GI) tract micronucleus (MN) tests to detect site-specific carcinogens has been shown previously using 22 chemicals in a study conducted by the Mammalian Mutagenicity Study group in the Japanese Environmental Mutagen Society. However, in the 6th International Workshop on Genotoxicit...
Misra, Sandip Mukherjee, Ananda Karmakar, Parimal
Published in
Mutation research
Mishra, Shravan Kumar Kumari, Niraj Krishnani, Narendra
Published in
Mutation research
Gallbladder carcinoma (GBC) is the most aggressive gastrointestinal malignancy throughout the world, with wide geographical variance. It is the subtype of biliary tract malignancy that has the poorest prognosis and lower survival among all biliary tract malignancies. Various factors are associated with GBC pathogenesis such as environmental, microb...
