Kasai, Fumio Hirayama, Noriko Kohara, Arihiro
Published in
Mutation research
The TK6 cell line has been widely used for genotoxicity screening by taking advantage of the TK1 mutations. A number of publications have employed TK6 as a tool for the assay; however, its characterization is limited. Because genomes of cell lines are often changed during cell culture, differences in TK6 genomes could be observed between laboratori...
Rosa-Silva, Helen Tais da Panzenhagen, Alana Castro Espitia-Pérez, Pedro Teixeira, Alexsander Alves Roitman, Alice Almeida, Roberto Farina Heimfarth, Luana Moreira, José Cláudio Fonseca
Published in
Mutation research
Methylmercury (MeHg) is known to be a chemical that poses a risk to public health. Exposure to MeHg and vitamin A (VitA) occurs through the ingestion of fish, present in the diet of most pregnant women. The absorption of these elements generates oxidative stress and can generate adaptations for future stressful events. Here, we assessed how exposur...
Bhardwaj, Jitender Kumar Saraf, Priyanka
Published in
Mutation research
Methoxychlor (MXC), an organo-chlorine insecticide, is a reproductive toxicant in females, causing apoptosis-mediated follicular atresia. To elucidate the potentials of Methoxychlor as a geno-toxicant, granulosa cells of healthy antral follicles, exposed to MXC and antioxidant, N-acetyl-l-cysteine, were studied by the terminal deoxynucleotidyltrans...
Shaban, Haitham A Seeber, Andrew
Published in
Mutation research
DNA damage induced global chromatin motion has been observed in yeast and mammalian cells. Currently, it is unclear what mechanisms may be driving these changes in whole genome dynamics. Recent advances in live-cell microscopy now enable chromatin motion to be quantified throughout the whole nucleus. In addition, much work has improved quantificati...
Jagetia, Ganesh Chandra Jacob, Preenu Sunil
Published in
Mutation research
We examined the effects of administration of (E) 4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP) on radiation-induced chromosome damage in mice. Mice were whole-body exposed to γ-rays, 0-4 Gy, and then immediately administered DMAP, 20 mg/kg. After 24 h, mice were sacrificed, femora were removed, marrow was extracted, and chromosome aberrations ...
Xue, Yanfeng Guo, Xiaoran Huang, Xinwei Zhu, Zongxin Chen, Minghui Chu, Jiang Yang, Guixian Wang, Qiang Kong, Xiangyang
Published in
Mutation research
Lung cancer and chronic obstructive pulmonary disease (COPD) are closely linked diseases. In Xuanwei, China, the extremely high incidence and mortality rates of lung cancer and COPD are associated with exposure to household smoky coal burning. Previous studies found that telomere length was related to lung disease. The objective of this study is to...
Singh, Sanjay Yennamalli, Ragothaman M Gupta, Manish Changotra, Harish
Published in
Mutation research
E2Fs transcription factors family is involved in the G1/S transition and DNA replication and their deregulated expression have been reported in various human cancers. Studies have shown that the genetic variants of E2F1 family members play an important role in head and neck carcinogenesis. In this study, we predicted six highly deleterious nsSNPs (...
Iida, M Harari, P M Wheeler, D L Toulany, M
Published in
Mutation research
The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα), AKT2 (PKBβ) and AKT3 (PKBγ). The PI3K/AKT pathway is normally activated by binding of ligands to membrane-bound receptor tyrosine kinases (RTKs) as well as downstream to G-pro...
Niazi, Yasmeen Thomsen, Hauke Smolkova, Bozena Vodickova, Ludmila Vodenkova, Soňa Kroupa, Michal Vymetalkova, Veronika Kazimirova, Alena Barancokova, Magdalena Volkovova, Katarina
...
Published in
Mutation research
Genomic instability is a characteristic of a majority of human malignancies. Chromosomal instability is a common form of genomic instability that can be caused by defects in mitotic checkpoint genes. Chromosomal aberrations in peripheral blood are also indicative of genotoxic exposure and potential cancer risk. We evaluated associations between inh...
Simar-Meintières, S Guigon, P Nesslany, F
Published in
Mutation research
Ferric hexacyanoferrate(II) (Fe4[Fe(CN)6]3), i.e. Prussian blue (PB) has been used for many years to remove from the body the two toxic isotopes of cesium and thallium following irradiation. Recently, potassium cobalt hexacyanoferrate(II) (K2COFe(CN)6), which has shown a better efficacy for decontamination, is also being considered for use to enhan...