Schwarz, Benjamin Friedl, Anna A Girst, Stefanie Dollinger, Günther Reindl, Judith
Published in
Mutation research
The accumulation and spatial distribution of 53BP1, BRCA1 and Rad51, key proteins in DNA double-strand break (DSB) repair, was investigated with high temporal resolution over a time span of 24 h, using STED nanoscopy. DNA lesions were induced by irradiation with high-LET (linear energy transfer) α-particles. We show that 53BP1 IRIF formation occurs...
Misra, Sandip Mukherjee, Ananda Karmakar, Parimal
Published in
Mutation research
Mishra, Shravan Kumar Kumari, Niraj Krishnani, Narendra
Published in
Mutation research
Gallbladder carcinoma (GBC) is the most aggressive gastrointestinal malignancy throughout the world, with wide geographical variance. It is the subtype of biliary tract malignancy that has the poorest prognosis and lower survival among all biliary tract malignancies. Various factors are associated with GBC pathogenesis such as environmental, microb...
Lawania, Shweta Singh, Amrita Sharma, Siddharth Singh, Navneet Behera, Digamber
Published in
Mutation research
It is evident that gene-gene interactions are pervasive in the determination of the susceptibility of human diseases. Polymorphisms in nucleotide excision repair pathway (NER) genes can cause variations in the repair capacity and therefore, might lead to increase in susceptibility towards lung cancer through complex gene-gene and gene-smoking inter...
Cirello, Valentina Colombo, Carla Pogliaghi, Gabriele Proverbio, Maria Carla Rossi, Stefania Mussani, Elena Tosi, Delfina Bulfamante, Gaetano Bonoldi, Emanuela Gherardi, Giorgio
...
Published in
Mutation research
Recently, the PARP4 gene has been identified as a possible susceptibility gene of primary thyroid and breast cancers. We analyzed PARP4 in 53 patients with multiple primary cancers including a thyroid cancer (TC), in 74 patients with TC alone, and in 88 healthy donors. Two PARP4 intronic variants within the IVS29 (c.3543 + 44T > C) and the IVS22 (c...
Zeiger, Errol
Published in
Mutation research
The bacterial strains and mutagenicity test procedure developed by Bruce Ames, and published in 1973, greatly enhanced the ability of laboratories to test chemicals for mutagenicity. The test that became known as the "Ames Test" was simple to perform, took only two days, was relatively inexpensive, and was easily transferrable to other laboratories...
Bagheri Hosseinabadi, Majid Khanjani, Narges Münzel, Thomas Daiber, Andreas Yaghmorloo, Mohammad
Published in
Mutation research
Noise levels experienced by industrial workers may cause both auditory and non-auditory harmful effects. We have studied the effects of chronic industrial noise exposure on DNA damage, blood pressure, and serum biochemistry in factory workers. Male workers (109 individuals) in three parts of a food factory in Shahroud, Iran were enrolled as the exp...
Gollapudi, P Bhat, V S Eastmond, D A
Published in
Mutation research
Topoisomerase II (topo II) inhibitors are commonly used as chemotherapy to treat multiple types of cancer, though their use is also associated with the development of therapy related acute leukemias. While the chromosome-damaging effects of etoposide, a topo II poison, have been proposed to act through a threshold mechanism, little is known about t...
Bocchi, Clara Bazzini, Cristina Fontana, Federica Pinto, Giancarlo Martino, Anna Cassoni, Francesca
Published in
Mutation research
Urban particulate matter (PM) is a complex mixture of several classes of chemicals: elemental carbon, ammonium, sulfates, nitrates, organic compounds and metals. For a long time, numerous studies had shown that PM causes health problems and, in 2013, it has been classified by the International Agency for Research on Cancer as carcinogenic to humans...
Drozd, Ewa Bubko, Irena Jaworska, Karolina Gruber-Bzura, Beata M
Published in
Mutation research
The MNa (in vitro the micronucleus assay) is recommended for studying genotoxicity of chemicals. However, no protocol is currently available for experiments with mouse fibroblast L929 cells. The aim of this study was to improve the scope of CBMNb (cytokinesis-block micronucleus) test. Optimization consisted of: selection of a non-cytotoxic concentr...
