Leavitt, Victoria M Brandstadter, Rachel Fabian, Michelle Katz Sand, Ilana Klineova, Sylvia Krieger, Stephen Lewis, Christina Lublin, Fred Miller, Aaron Pelle, Gabrielle
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Individuals with multiple sclerosis (MS) frequently present with depression and anxiety, as well as cognitive impairment, challenging clinicians to disentangle interrelationships among these symptoms. To identify cognitive functions associated with anxiety and depression in MS. Mood and cognition were measured in 185 recently diagnosed patients (Re...
Gabr, Refaat E Coronado, Ivan Robinson, Melvin Sujit, Sheeba J Datta, Sushmita Sun, Xiaojun Allen, William J Lublin, Fred D Wolinsky, Jerry S Narayana, Ponnada A
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
To investigate the performance of deep learning (DL) based on fully convolutional neural network (FCNN) in segmenting brain tissues in a large cohort of multiple sclerosis (MS) patients. We developed a FCNN model to segment brain tissues, including T2-hyperintense MS lesions. The training, validation, and testing of FCNN were based on ~1000 magneti...
Stampanoni Bassi, Mario Iezzi, Ennio Buttari, Fabio Gilio, Luana Simonelli, Ilaria Carbone, Fortunata Micillo, Teresa De Rosa, Veronica Sica, Francesco Furlan, Roberto
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Previous studies evidenced a link between metabolic dysregulation, inflammation, and neurodegeneration in multiple sclerosis (MS). To explore whether increased adipocyte mass expressed as body mass index (BMI) and increased serum lipids influence cerebrospinal fluid (CSF) inflammation and disease severity. In this cross-sectional study, 140 consecu...
Scarpazza, Cristina Signori, Alessio Cosottini, Mirco Sormani, Maria Pia Gerevini, Simonetta Capra, Ruggero
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Brain magnetic resonance imaging (MRI) is the most effective surveillance tool for the detection of asymptomatic progressive multifocal leukoencephalopathy (PML). However, the optimal frequency for routine MRI surveillance is under-investigated. To understand whether, upon their first MRI appearance, PML lesions present a difference in volume when ...
Jordan, Allison Lm Yang, Jennifer Fisher, Caitlyn J Racke, Michael K Mao-Draayer, Yang
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Dimethyl fumarate (DMF), a fumaric acid with antioxidant and immunomodulatory properties, is among the most commonly used oral therapies for relapsing multiple sclerosis (MS). Progressive multifocal leukoencephalopathy (PML) has been associated with several disease-modifying therapies (DMTs), including DMF in treating MS. We present detailed clinic...
Marrie, Ruth Ann Dufault, Brenden Tyry, Tuula Cutter, Gary R Fox, Robert J Salter, Amber
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Researchers studying health-related quality of life (HRQOL) in multiple sclerosis (MS) can choose from many instruments, but findings from studies which use different instruments cannot be easily combined. We aimed to develop a crosswalk that associates scores from the RAND-12 to scores on the Health Utilities Index-Mark III (HUI3) in persons with ...
Comi, Giancarlo Miller, Aaron E Benamor, Myriam Truffinet, Philippe Poole, Elizabeth M Freedman, Mark S
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
In Phase 3 studies, teriflunomide reduced relapse rates and disability progression compared with placebo; however, decreases in lymphocyte counts were also observed. To describe the effect of long-term teriflunomide treatment on lymphocyte counts and infection rates among patients in pooled analyses of Phase 3 core and extension studies. Four rando...
Klineova, Sylvia Brandstadter, Rachel Fabian, Michelle T Sand, Ilana Katz Krieger, Stephen Leavitt, Victoria M Lewis, Christina Riley, Claire S Lublin, Fred Miller, Aaron E
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Psychologically resilient persons persist despite obstacles and bounce back after adversity, leading to better outcomes in non-neurologic populations. It is unknown whether psychological resilience relates to objective functional outcomes in multiple sclerosis (MS). To determine whether psychological resilience explains differential objective cogni...
D'Souza, Marcus Heikkilä, Antti Lorscheider, Johannes Haller, Vanessa Kravalis, Kristina Gysin, Shauna Fuertes, Nuria Alicia Cerdá Fricker, Evy Lam, Elaine Higgins, Peter
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
The Neurostatus-eEDSS is an electronic tool providing automated real-time feedback on inconsistencies of Neurostatus-EDSS calculations. To analyze the performance of the Neurostatus-eEDSS in two multicenter phase 3 multiple sclerosis (MS) trials. All assessments captured with the Neurostatus-eEDSS web service during a period of 2.5 years were analy...
Ciron, Jonathan Cobo-Calvo, Alvaro Audoin, Bertrand Bourre, Bertrand Brassat, David Cohen, Mikael Collongues, Nicolas Deschamps, Romain Durand-Dubief, Françoise Laplaud, David
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
We aim to (1) determine the frequency and distinctive features of short myelitis (SM) and longitudinally extensive transverse myelitis (LETM) in a cohort of adults with myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab)-associated myelitis and (2) determine baseline prognostic factors among MOG-Ab-positive patients whose disease started with m...
