Mehndiratta, Ambica Treaba, Constantina A Barletta, Valeria Herranz, Elena Ouellette, Russell Sloane, Jacob A Klawiter, Eric C Kinkel, Revere P Mainero, Caterina
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Multiple sclerosis (Houndmills, Basingstoke, England)
Thalamic pathology is a marker for neurodegeneration and multiple sclerosis (MS) disease progression. To characterize (1) the morphology of thalamic lesions, (2) their relation to cortical and white matter (WM) lesions, and (3) clinical measures, and to assess (4) the imaging correlates of thalamic atrophy. A total of 90 MS patients and 44 healthy ...
Bsteh, Gabriel Berek, Klaus Hegen, Harald Altmann, Patrick Wurth, Sebastian Auer, Michael Zinganell, Anne Di Pauli, Franziska Rommer, Paulus Leutmezer, Fritz
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Macular ganglion cell-inner plexiform layer (mGCIPL) is an emerging biomarker of neuroaxonal degeneration in multiple sclerosis (MS). We aimed to determine cut-off values of mGCIPL thinning for discriminating between progressing and stable patients in relapsing multiple sclerosis (RMS). This is a 3-year prospective longitudinal study on 183 RMS pat...
Conway, Devon S Thompson, Nicolas R Meng, Xiangyi Johnson, Kristen Fox, Robert J
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Multiple sclerosis (Houndmills, Basingstoke, England)
Relapsing-remitting multiple sclerosis (RRMS) usually evolves into secondary progressive multiple sclerosis (SPMS). Recognition of SPMS is important because of prognostic and treatment implications. The objective of this study is to determine distributions of patient-reported outcomes (PROs) and the Timed 25-Foot Walk (T25FW) at SPMS diagnosis and ...
Smith, Angela Davies Prokopiusova, Terezie Jones, Rosemary Burge, Tania Rasova, Kamila
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Multiple sclerosis (Houndmills, Basingstoke, England)
Impaired mobility is common in people with multiple sclerosis (MS). Changes in gait have different causes and require individualised gait rehabilitation. A common and often early cause of mobility impairment is footdrop, inability to lift the foot during the swing phase of gait, with increased risk of falls, effortful walking and fatigue. Using lit...
Demortiere, Sarah Rico, Audrey Maarouf, Adil Boutiere, Clémence Pelletier, Jean Audoin, Bertrand
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Multiple sclerosis (Houndmills, Basingstoke, England)
Planning pregnancy in patients with active multiple sclerosis (MS) is highly challenging because treatment withdrawn may be associated with dramatic disease reactivation. To compare two strategies for women with active MS who were planning pregnancy: stopping natalizumab (1) at the end of the first trimester and (2) at conception. Standardized stra...
Mancinelli, Chiara Rosa Scarpazza, Cristina Cordioli, Cinzia De Rossi, Nicola Rasia, Sarah Turrini, Maria Vittoria Capra, Ruggero
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Multiple sclerosis (Houndmills, Basingstoke, England)
Discontinuation of natalizumab in patients with relapsing-remitting multiple sclerosis (RRMS) at risk of progressive multifocal leukoencephalopathy (PML) is associated with disease reactivation. Forty-two RRMS patients, who switched from an extended interval dose (EID) of natalizumab to ocrelizumab, underwent magnetic resonance imaging (MRI) and cl...
Kunchok, Amy Lechner-Scott, Jeannette Granella, Franco Trojano, Maria Alroughani, Raed Sola, Patrizia Ferraro, Diana Lugaresi, Alessandra Onofrj, Marco Ozakbas, Serkan
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
The magnetic resonance imaging in multiple sclerosis (MAGNIMS) score combines relapses and magnetic resonance imaging (MRI) lesions to predict disability outcomes in relapsing-remitting multiple sclerosis (RRMS) treated with interferon-β. To validate the MAGNIMS score and extend to other disease-modifying therapies (DMTs). To examine the prognostic...
Le, Minh Malpas, Charles Sharmin, Sifat Horáková, Dana Havrdova, Eva Trojano, Maria Izquierdo, Guillermo Eichau, Sara Ozakbas, Serkan Lugaresi, Alessandra
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Cerebellar and brainstem symptoms are common in early stages of multiple sclerosis (MS) yet their prognostic values remain unclear. The aim of this study was to investigate long-term disability outcomes in patients with early cerebellar and brainstem symptoms. This study used data from MSBase registry. Patients with early cerebellar/brainstem prese...
Sechi, Elia Messina, Steven Keegan, B Mark Buciuc, Marina Pittock, Sean J Kantarci, Orhun H Weinshenker, Brian G Flanagan, Eoin P
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Multiple sclerosis (Houndmills, Basingstoke, England)
Progressive motor impairment anatomically attributable to prominent, focally atrophic lateral column spinal cord lesions ("critical lesions") can be seen in multiple sclerosis (MS), for example, progressive hemiparetic MS. The aim of this study was to investigate whether similar spinal cord lesions are more frequent in long-standing MS patients wit...
Celius, Elisabeth G
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
