Mizell, Ryan Chen, Hegang Lambe, Jeffrey Saidha, Shiv Harrison, Daniel M
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Retinal atrophy in multiple sclerosis (MS) as measured by optical coherence tomography (OCT) correlates with demyelinating lesions and brain atrophy, but its relationship with cortical lesions (CLs) and meningeal inflammation is not well known. To evaluate the relationship of retinal layer atrophy with leptomeningeal enhancement (LME) and CLs in MS...
Bommarito, Giulia Tarun, Anjali Farouj, Younes Preti, Maria Giulia Petracca, Maria Droby, Amgad El Mendili, Mohamed Mounir Inglese, Matilde Van De Ville, Dimitri
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Modifications in brain function remain relatively unexplored in progressive multiple sclerosis (PMS), despite their potential to provide new insights into the pathophysiology of the disease at this stage. To characterize the dynamics of functional networks at rest in patients with PMS, and the relation with clinical disability. Thirty-two patients ...
Morgan, Megan L Kaushik, Deepak K Stys, Peter K Caprariello, Andrew V
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
The balance of tissue injury and repair ultimately determines outcomes of chronic neurological disorders, such as progressive multiple sclerosis (MS). However, the extent of pathology can be difficult to detect, particularly when it is insidious and/or offset by tissue regeneration. The objective of this research is to evaluate whether tissue autof...
Boffa, Giacomo Sbragia, Elvira Raiola, Anna Maria Varaldo, Riccardo Capello, Elisabetta Gallo, Paolo Granella, Franco Mancardi, Gianluigi Inglese, Matilde
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
The management of multiple sclerosis patients with persistent disease activity under alemtuzumab treatment is not established yet. Concerns have been raised on the safety of autologous haematopoietic stem cell transplantation (aHSCT) after alemtuzumab treatment because of the risk of serious infectious adverse events. We report short-term safety an...
Ringh, Mikael V Hagemann-Jensen, Michael Needhamsen, Maria Kullberg, Susanna Wahlström, Jan Grunewald, Johan Brynedal, Boel Jagodic, Maja Ekström, Tomas J Öckinger, Johan
...
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Despite compelling evidence that cigarette smoking impacts the risk of developing multiple sclerosis (MS), little is known about smoking-associated changes in the primary exposed lung cells of patients. We aimed to examine molecular changes occurring in bronchoalveolar lavage (BAL) cells from MS patients in relation to smoking and in comparison to ...
Castelli, Letizia Quartuccio, Maria Esmeralda Ruggieri, Serena De Giglio, Laura Prosperini, Luca
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
We assessed 168 patients with multiple sclerosis (MS) by force platform to obtain the dual-task cost (DTC) of balance, that is, the change in postural sway from quiet standing to dual-task condition (Stroop test). After a median follow-up time of 3.5 years from this assessment, disability progression occurred in 45 (27%) patients. Disability progre...
Guisset, François Lolli, Valentina Bugli, Céline Perrotta, Gaetano Absil, Julie Dachy, Bernard Pot, Caroline Théaudin, Marie Pasi, Marco van Pesch, Vincent
...
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
The central vein sign (CVS) is an imaging biomarker able to differentiate multiple sclerosis (MS) from other conditions causing similar appearance lesions on magnetic resonance imaging (MRI), including cerebral small vessel disease (CSVD). However, the impact of vascular risk factors (VRFs) for CSVD on the percentage of CVS positive (CVS+) lesions ...
Morrow, Sarah A Conway, Devon Fuchs, Tom Wojcik, Curtis Unverdi, Mahmut Yasin, Faizan Pol, Jeta Eckert, Sveltlana Hojnacki, David H Dwyer, Michael
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Cognition is affected by relapses in persons with multiple sclerosis (PwMS), yet the Expanded Disability Status Scale (EDSS) does not readily detect cognitive changes. The objective of this study is to improve the detection of cognitive decline during relapses, by incorporating the Symbol Digit Modalities Test (SDMT) into the cerebral Functional Sy...
Joisten, Niklas Proschinger, Sebastian Rademacher, Annette Schenk, Alexander Bloch, Wilhelm Warnke, Clemens Gonzenbach, Roman Kool, Jan Bansi, Jens Zimmer, Philipp
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Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
In persons with multiple sclerosis (PwMS), the neutrophil-to-lymphocyte ratio (NLR) is associated with disability status, symptomatology and disease activity. High-intensity interval training (HIIT) improves many symptoms in PwMS and may positively influence disease progression. Here, we present results from a randomized controlled trial during inp...
Jaworski, Michael G 3rd Fuchs, Tom A Dwyer, Michael G Wojcik, Curtis Zivadinov, Robert Weinstock-Guttman, Bianca Benedict, Ralph Hb
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Physical and cognitive symptoms of multiple sclerosis (MS) correlate with unemployment cross-sectionally. Prospective studies, rarely published, have not accounted for personality traits such as Conscientiousness. In a 3-year study of 70 people with MS (PwMS) and 25 healthy controls (HCs), we evaluated employment status using online interviews capt...
