Cambeiro-Pérez, Noelia González-Gómez, Xiana González-Barreiro, Carmen Pérez-Gregorio, María Rosa Fernandes, Iva Mateus, Nuno de Freitas, Victor Sánchez, Borja Martínez-Carballo, Elena
Published in
Molecules (Basel, Switzerland)
Dihydrochalcones, phlorizin (PZ) and its aglycone phloretin (PT), have evidenced immunomodulatory effects through several mechanisms. However, the differential metabolic signatures that lead to these properties are largely unknown. Since macrophages play an important role in the immune response, our study aimed to characterise human THP-1 macrophag...
Mohamad Aziz, Nur Atiqah Yunus, Robiah Kania, Dina Abd Hamid, Hamidah
Published in
Molecules (Basel, Switzerland)
Biodiesels and biolubricants are synthetic esters produced mainly via a transesterification of other esters from bio-based resources, such as plant-based oils or animal fats. Microwave heating has been used to enhance transesterification reaction by converting an electrical energy into a radiation, becoming part of the internal energy acquired by r...
Mieczkowski, Adam Speina, Elżbieta Trzybiński, Damian Winiewska-Szajewska, Maria Wińska, Patrycja Borsuk, Ewelina M Podsiadła-Białoskórska, Małgorzata Przygodzki, Tomasz Drabikowski, Krzysztof Stanczyk, Lidia
...
Published in
Molecules (Basel, Switzerland)
Phosphodiesterase 5 (PDE5) is one of the most extensively studied phosphodiesterases that is highly specific for cyclic-GMP hydrolysis. PDE5 became a target for drug development based on its efficacy for treatment of erectile dysfunction. In the present study, we synthesized four novel analogues of the phosphodiesterase type 5 (PDE5) inhibitor-tada...
González-Rodríguez, María Ruiz-Fernández, Clara Francisco, Vera Ait Eldjoudi, Djedjiga Farrag AbdElHafez, Yousof Ramadan Cordero-Barreal, Alfonso Pino, Jesus Lago, Francisca Campos-Toimil, Manuel Rocha Carvalho, Glaucimeire
...
Published in
Molecules (Basel, Switzerland)
Virola is the largest genus of Myristicaceae in America, comprising about 60 species of medium-sized trees geographically spread from Mexico to southern Brazil. The plant species of this genus have been widely used in folk medicine for the treatment of several ailments, such as rheumatic pain, bronchial asthma, tumors in the joints, intestinal worm...
Zhang, Jing Tan, Yaling Li, Guorong Chen, Lexian Nie, Minyi Wang, Zhaohua Ji, Hong
Published in
Molecules (Basel, Switzerland)
Coumarins possesses immeasurable antitumor potential with minimum side effects depending on the substitutions on the basic nucleus, which exhibits great prospects for antitumor drug development. In an attempt to develop novel antitumor candidates, a series of coumarin sulfonamides and amides derivatives were designed and synthetized. The majority o...
Tejera, Eduardo Pérez-Castillo, Yunierkis Chamorro, Andrea Cabrera-Andrade, Alejandro Sanchez, Maria Eugenia
Published in
Molecules (Basel, Switzerland)
Preeclampsia is a hypertensive disorder that occurs during pregnancy. It is a complex disease with unknown pathogenesis and the leading cause of fetal and maternal mortality during pregnancy. Using all drugs currently under clinical trial for preeclampsia, we extracted all their possible targets from the DrugBank and ChEMBL databases and labeled th...
Shim, Ki-Shuk Hwang, Youn-Hwan Jang, Seon-A Kim, Taesoo Ha, Hyunil
Published in
Molecules (Basel, Switzerland)
In Asia, Amomum tsao-ko has long been used as a spice or seasoning in food to stimulate digestion. In the present study, we evaluated the effects of ethanol extract of Amomum tsao-ko (EEAT) on menopausal osteoporosis and obesity. After the administration of EEAT in ovariectomy (OVX) mice models for five weeks, microcomputed tomography and a histolo...
Otręba, Michał Kośmider, Leon Rzepecka-Stojko, Anna
Published in
Molecules (Basel, Switzerland)
According to the World Health Organization, cardiovascular diseases are responsible for 31% of global deaths. A reduction in mortality can be achieved by promoting a healthy lifestyle, developing prevention strategies, and developing new therapies. Polyphenols are present in food and drinks such as tea, cocoa, fruits, berries, and vegetables. These...
Tsochatzis, Emmanouil D Alberto Lopes, Joao Holland, Margaret V Reniero, Fabiano Palmieri, Giovanni Guillou, Claude
Published in
Molecules (Basel, Switzerland)
The rapid diffusion of new psychoactive substances (NPS) presents unprecedented challenges to both customs authorities and analytical laboratories involved in their detection and characterization. In this study an analytical approach to the identification and structural elucidation of a novel synthetic cannabimimetic, quinolin-8-yl-3-[(4,4-difluoro...
Ismail, Ahmad Safwan Jawaid, Mohammad Hamid, Norul Hisham Yahaya, Ridwan Hassan, Azman
Published in
Molecules (Basel, Switzerland)
Polymer blends is a well-established and suitable method to produced new polymeric materials as compared to synthesis of a new polymer. The combination of two different types of polymers will produce a new and unique material, which has the attribute of both polymers. The aim of this work is to analyze mechanical and morphological properties of bio...
