Rushing, Blake R Rohlik, Denise L Roy, Sourav Skaff, D Andrew Garcia, Brandon L
Published in
Molecules (Basel, Switzerland)
The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related autoimmune and inflammatory diseases. Yet, C1r-targeted therapeutic development is currently underrepresented relative to other complement targets. In this study, we developed a fragment-based drug ...
Alluri, Santosh Reddy Kim, Sung Won Volkow, Nora D Kil, Kun-Eek
Published in
Molecules (Basel, Switzerland)
Epinephrine (E) and norepinephrine (NE) play diverse roles in our body's physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health. Various antipsychotics, antidepressants, and psychostimulants exert their influence parti...
Paiva, Paula P de Nunes, Julia H B Nonato, Fabiana R Ruiz, Ana L T G Zafred, Rafael R T Sousa, Ilza M O Okubo, Márcia Y Kawano, Daniel F Monteiro, Paula A Foglio, Mary A
...
Published in
Molecules (Basel, Switzerland)
In the context of the cancer-inflammation relationship and the use of natural products as potential antitumor and anti-inflammatory agents, the alkaloid-enriched fraction of Boehmeriacaudata (BcAEF) aerial parts was evaluated. In vitro antiproliferative studies with human tumor cell lines showed high activity at low concentrations. Further investig...
Kemboi, Douglas Peter, Xolani Langat, Moses Tembu, Jacqueline
Published in
Molecules (Basel, Switzerland)
The genus Euphorbia is one of the largest genera in the spurge family, with diversity in range, distribution, and morphology. The plant species in this genus are widely used in traditional medicine for the treatment of diseases, ranging from respirational infections, body and skin irritations, digestion complaints, inflammatory infections, body pai...
Wu, Jing-Shuai Shi, Xiao-Hui Zhang, Ya-Hui Shao, Chang-Lun Fu, Xiu-Mei Li, Xin Yao, Guang-Shan Wang, Chang-Yun
Published in
Molecules (Basel, Switzerland)
Chemical epigenetic modification on a marine-derived fungus Aspergillus terreus RA2905 using a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), resulted in a significantly changed metabolic profile. A chemical investigation of its ethyl acetate (EtOAc) extract led to the isolation of a racemate of benzyl furanone racemate (±)-...
Silva, Eric Keven Bargas, Matheus A Arruda, Henrique S Vardanega, Renata Pastore, Glaucia M Meireles, M Angela A
Published in
Molecules (Basel, Switzerland)
The effects of supercritical CO2 processing on the chemical stability of fructooligosaccharides (FOS) and other functional and nutritional compounds were evaluated employing non-thermal and thermal approaches. Apple juice was enriched with Pfaffia glomerata roots aqueous extract due to its high content of short-chain FOS and then subjected to diffe...
Aminina, Natalia M Karaulova, Ekaterina P Vishnevskaya, Tatiana I Yakush, Evgeny V Kim, Yeon-Kye Nam, Ki-Ho Son, Kwang-Tae
Published in
Molecules (Basel, Switzerland)
Water and ethanol brown macroalgal extracts of nine species of Laminariales and four species of Fucales of the Pacific coast of Russia were investigated. It has been shown that brown algae species of Agarum, Thalassiophyllum, Fucus and Cystoseira can be a source of the polyphenolic compounds with antioxidant activity. Phenolic content in the ethano...
Gafarova, Elvira R Grebenik, Ekaterina A Lazhko, Alexey E Frolova, Anastasia A Kuryanova, Anastasia S Kurkov, Alexandr V Bazhanov, Ilya A Kapomba, Byron S Kosheleva, Nastasia V Novikov, Ivan A
...
Published in
Molecules (Basel, Switzerland)
One of the leading trends in the modern tissue engineering is the development of new effective methods of decellularization aimed at the removal of cellular components from a donor tissue, reducing its immunogenicity and the risk of rejection. Supercritical CO2 (scCO2)-assisted processing has been proposed to improve the outcome of decellularizatio...
Adamczewska, Katarzyna Adamczewski, Zbigniew Łupińska, Anna Lewiński, Andrzej Stawerska, Renata
Published in
Molecules (Basel, Switzerland)
The growth processes in children depend on the proper functioning of some hormones and growth factors. Recently, a positive correlation between ghrelin and TSH (thyroid stimulating hormone) in patients with hyper- and hypothyroidism was proved. Moreover, in hypothyroid rats with high ghrelin concentration, growth hormone (GH) and insulin-like growt...
Jeong, Seongtae Lee, Seahyoung Kim, Kundo Lee, Yunmi Lee, Jiyun Oh, Sena Choi, Jung-Won Kim, Sang Woo Hwang, Ki-Chul Lim, Soyeon
...
Published in
Molecules (Basel, Switzerland)
Bone diseases may not be imminently life-threatening or a leading cause of death such as heart diseases or cancers. However, as aging population grows in almost every part of the world, they surely impose significant socioeconomic burden on the society, not to mention the patients and their families. Osteoporosis is the most common type of bone dis...
